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Sequential Scintigraphy in Renal Transplantation

Conference:

Abstract

Based on experience gained from more than 1600 patients with proved or suspected kidney diseases and on results on extended studies with dogs, sequential scintigraphy was performed after renal transplantation in dogs. After intravenous injection of 500 {mu}Ci. {sup 131}I-Hippuran scintiphotos were taken during the first minute with an exposure time of 15 sec each and thereafter with an exposure of 2 min up to at least 16 min.. Several examinations were evaluated digitally. 26 examinations were performed on 11 dogs with homotransplanted kidneys. Immediately after transplantation the renal function was almost normal arid the bladder was filled in due time. At the beginning of rejection the initial uptake of radioactive Hippuran was reduced. The intrarenal transport became delayed; probably the renal extraction rate decreased. Corresponding to the development of an oedema in the transplant the uptake area increased in size. In cases of thrombosis of the main artery there was no evidence of any uptake of radioactivity in the transplant. Similar results were obtained in 41 examinations on 15 persons. Patients with postoperative anuria due to acute tubular necrosis showed still some uptake of radioactivity contrary to those with thrombosis of the renal artery, where no uptake was found.  More>>
Authors:
Winkel, K. zum; Harbst, H.; Schenck, P.; Franz, H. E.; Ritz, E.; Roehl, L.; Ziegler, M.; Ammann, W.; Maier-Borst, W. [1] 
  1. Institut Fuer Nuklearmedizin, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany (Germany)
Publication Date:
May 15, 1969
Product Type:
Conference
Report Number:
IAEA-SM-108/58
Resource Relation:
Conference: Symposium on Medical Radioisotope Scintigraphy, Salzburg (Austria), 6-15 Aug 1968; Other Information: 14 refs., 5 figs., 3 tabs.; Related Information: In: Medical Radioisotope Scintigraphy. Proceedings of a Symposium on Medical Radioisotope Scintigraphy. V. II| 952 p.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 60 APPLIED LIFE SCIENCES; ARTERIES; BLADDER; DOGS; HIPPURAN; INTRAVENOUS INJECTION; IODINE 131; KIDNEYS; NECROSIS; PATIENTS; RADIOACTIVITY; SCINTISCANNING; THROMBOSIS; UPTAKE
OSTI ID:
22108000
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ISSN 0074-1884; TRN: XA13M0481065811
Submitting Site:
INIS
Size:
page(s) 197-208
Announcement Date:
Jun 27, 2013

Conference:

Citation Formats

Winkel, K. zum, Harbst, H., Schenck, P., Franz, H. E., Ritz, E., Roehl, L., Ziegler, M., Ammann, W., and Maier-Borst, W. Sequential Scintigraphy in Renal Transplantation. IAEA: N. p., 1969. Web.
Winkel, K. zum, Harbst, H., Schenck, P., Franz, H. E., Ritz, E., Roehl, L., Ziegler, M., Ammann, W., & Maier-Borst, W. Sequential Scintigraphy in Renal Transplantation. IAEA.
Winkel, K. zum, Harbst, H., Schenck, P., Franz, H. E., Ritz, E., Roehl, L., Ziegler, M., Ammann, W., and Maier-Borst, W. 1969. "Sequential Scintigraphy in Renal Transplantation." IAEA.
@misc{etde_22108000,
title = {Sequential Scintigraphy in Renal Transplantation}
author = {Winkel, K. zum, Harbst, H., Schenck, P., Franz, H. E., Ritz, E., Roehl, L., Ziegler, M., Ammann, W., and Maier-Borst, W.}
abstractNote = {Based on experience gained from more than 1600 patients with proved or suspected kidney diseases and on results on extended studies with dogs, sequential scintigraphy was performed after renal transplantation in dogs. After intravenous injection of 500 {mu}Ci. {sup 131}I-Hippuran scintiphotos were taken during the first minute with an exposure time of 15 sec each and thereafter with an exposure of 2 min up to at least 16 min.. Several examinations were evaluated digitally. 26 examinations were performed on 11 dogs with homotransplanted kidneys. Immediately after transplantation the renal function was almost normal arid the bladder was filled in due time. At the beginning of rejection the initial uptake of radioactive Hippuran was reduced. The intrarenal transport became delayed; probably the renal extraction rate decreased. Corresponding to the development of an oedema in the transplant the uptake area increased in size. In cases of thrombosis of the main artery there was no evidence of any uptake of radioactivity in the transplant. Similar results were obtained in 41 examinations on 15 persons. Patients with postoperative anuria due to acute tubular necrosis showed still some uptake of radioactivity contrary to those with thrombosis of the renal artery, where no uptake was found. In cases of rejection the most frequent signs were a reduced initial uptake and a delayed intrarenal transport of radioactive Hippuran. Infarction could be detected by a reduced uptake in distinct areas of the transplant. (author)}
place = {IAEA}
year = {1969}
month = {May}
}