Abstract
Radiocarbon-11 decays with 20.3-min half-life by emitting positrons with 1.0-MeV maximum energy. Two 511-keV {sup {+-}}{gamma}-photons almost always are emitted coincidentally with each disintegration, at 180 Degree-Sign to each other. This 'back-to-back' relationship makes it possible readily to locate small accumulations of {sup 11}C in vivo by opposed detectors connected by coincidence circuitry. The calculated narrow-beam half-thickness in water is more than 7 cm, to provide good penetration from deep organs, and with little scatter. Multimillicurie amounts of a mixture of {sup 11}CO and {sup 11}CO{sub 2} are generated readily in our small cyclotron when probe targets of B{sub 2}O{sub 3} are bombarded with protons, deuterons, or {sup 3}He{sup ++} ions. The {sup 11}CO is oxidized to {sup 11}CO{sub 2} by hopcalite placed in the vacuum line. Dogs with primary or metastatic bone tumours received {sup 11}CO{sub 2}, either by inhalation in a closed system, or in slightly basic solution in travenously. Scintigraphs, that were obtained within 10-20 min by means of a Nuclear-Chicago focused-collimator scanning machine, revealed significant accumulations of {sup 11}C at sites where bone erosion was demonstrable roentgenographically. Good pictures of dog lungs were obtained either with the mechanical scanner, or with our Nuclear-Chicago scintillation camera, after
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Myers, W. G.;
Hunter, Jr., W. W.
[1]
- Ohio State University Health Center, Columbus, OH (United States)
Citation Formats
Myers, W. G., and Hunter, Jr., W. W.
Carbon-11 in Bone and Lung Scanning.
IAEA: N. p.,
1969.
Web.
Myers, W. G., & Hunter, Jr., W. W.
Carbon-11 in Bone and Lung Scanning.
IAEA.
Myers, W. G., and Hunter, Jr., W. W.
1969.
"Carbon-11 in Bone and Lung Scanning."
IAEA.
@misc{etde_22107989,
title = {Carbon-11 in Bone and Lung Scanning}
author = {Myers, W. G., and Hunter, Jr., W. W.}
abstractNote = {Radiocarbon-11 decays with 20.3-min half-life by emitting positrons with 1.0-MeV maximum energy. Two 511-keV {sup {+-}}{gamma}-photons almost always are emitted coincidentally with each disintegration, at 180 Degree-Sign to each other. This 'back-to-back' relationship makes it possible readily to locate small accumulations of {sup 11}C in vivo by opposed detectors connected by coincidence circuitry. The calculated narrow-beam half-thickness in water is more than 7 cm, to provide good penetration from deep organs, and with little scatter. Multimillicurie amounts of a mixture of {sup 11}CO and {sup 11}CO{sub 2} are generated readily in our small cyclotron when probe targets of B{sub 2}O{sub 3} are bombarded with protons, deuterons, or {sup 3}He{sup ++} ions. The {sup 11}CO is oxidized to {sup 11}CO{sub 2} by hopcalite placed in the vacuum line. Dogs with primary or metastatic bone tumours received {sup 11}CO{sub 2}, either by inhalation in a closed system, or in slightly basic solution in travenously. Scintigraphs, that were obtained within 10-20 min by means of a Nuclear-Chicago focused-collimator scanning machine, revealed significant accumulations of {sup 11}C at sites where bone erosion was demonstrable roentgenographically. Good pictures of dog lungs were obtained either with the mechanical scanner, or with our Nuclear-Chicago scintillation camera, after intravenous injection of 4-12 {mu}m diam. smoothly-rounded aggregates of SrCO{sub 3} that were formed in dextran-saline solution. These 'photon-carrier' aggregates have been made either with {sup 11}C; or with 2.8-h {sup 87m}Sr, which emits 388-keV gamma-rays. Alternatively, they might be made to 'carry' the 231-keV gamma-rays of 70-m in {sup 85m}Sr, that are advantageous for scintigraphy. The advent of Anger's positron camera, with choice of plane of prime interest, will provide opportunities to emphasize the maximum target/nontarget ratio in pictures of localized accumulations of {sup 11}C, as well as of {sup 13}N, {sup 15}O and other cyclotron-produced short-lived {beta}{sup +}-isotopes of abundant physiologically important elements. (author)}
place = {IAEA}
year = {1969}
month = {May}
}
title = {Carbon-11 in Bone and Lung Scanning}
author = {Myers, W. G., and Hunter, Jr., W. W.}
abstractNote = {Radiocarbon-11 decays with 20.3-min half-life by emitting positrons with 1.0-MeV maximum energy. Two 511-keV {sup {+-}}{gamma}-photons almost always are emitted coincidentally with each disintegration, at 180 Degree-Sign to each other. This 'back-to-back' relationship makes it possible readily to locate small accumulations of {sup 11}C in vivo by opposed detectors connected by coincidence circuitry. The calculated narrow-beam half-thickness in water is more than 7 cm, to provide good penetration from deep organs, and with little scatter. Multimillicurie amounts of a mixture of {sup 11}CO and {sup 11}CO{sub 2} are generated readily in our small cyclotron when probe targets of B{sub 2}O{sub 3} are bombarded with protons, deuterons, or {sup 3}He{sup ++} ions. The {sup 11}CO is oxidized to {sup 11}CO{sub 2} by hopcalite placed in the vacuum line. Dogs with primary or metastatic bone tumours received {sup 11}CO{sub 2}, either by inhalation in a closed system, or in slightly basic solution in travenously. Scintigraphs, that were obtained within 10-20 min by means of a Nuclear-Chicago focused-collimator scanning machine, revealed significant accumulations of {sup 11}C at sites where bone erosion was demonstrable roentgenographically. Good pictures of dog lungs were obtained either with the mechanical scanner, or with our Nuclear-Chicago scintillation camera, after intravenous injection of 4-12 {mu}m diam. smoothly-rounded aggregates of SrCO{sub 3} that were formed in dextran-saline solution. These 'photon-carrier' aggregates have been made either with {sup 11}C; or with 2.8-h {sup 87m}Sr, which emits 388-keV gamma-rays. Alternatively, they might be made to 'carry' the 231-keV gamma-rays of 70-m in {sup 85m}Sr, that are advantageous for scintigraphy. The advent of Anger's positron camera, with choice of plane of prime interest, will provide opportunities to emphasize the maximum target/nontarget ratio in pictures of localized accumulations of {sup 11}C, as well as of {sup 13}N, {sup 15}O and other cyclotron-produced short-lived {beta}{sup +}-isotopes of abundant physiologically important elements. (author)}
place = {IAEA}
year = {1969}
month = {May}
}