Abstract
The separate and combined in vitro toxic effects of antibiotics (ciprofloxacin, erythromycin, novobiocin, oxytetracycline, sulfamethazole and trimethoprim) commonly found in urban wastewater effluents were assessed on the immune parameters of Elliptio complanata at environmentally relevant concentrations. The observed responses were then compared to those produced by the physicochemical-treated wastewater effluent of a major city before and after the removal of microorganisms. Most of the selected antibiotics, separately and as mixture, induced changes in immune responses. The removal of microorganisms and fine particles from the effluent increased or decreased the resulting immunotoxic effects, depending of the observed parameter. The immunotoxic effects of erythromycin, sulfamethoxazole and trimethoprim were closely associated to the antibiotic mixture and the filtered effluent. In conclusion, the data revealed that the removal of fine particles and microorganisms from municipal effluents can alter the toxic nature of the effluent that is closely associated with the cumulative effects of antibiotics. - Highlights: Black-Right-Pointing-Pointer Environmental concentrations of antibiotics induce the immune response in mussels. Black-Right-Pointing-Pointer Antibiotic mixture also modulate the immune response. Black-Right-Pointing-Pointer Urban effluent, both filtered and unfiltered also increase the immune response. Black-Right-Pointing-Pointer Filtered effluent, antibiotic mixture and 3 antibiotics induced similar responses. - Environmentally relevant concentration of antibiotics
More>>
Gust, M;
[1]
IRSTEA, UR MAEP, Laboratoire d'ecotoxicologie, 3 bis quai Chauveau, 69009 Lyon (France)];
Gelinas, M;
[1]
Fortier, M;
Fournier, M;
[2]
Gagne, F;
[1]
INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)]
- Fluvial Ecosystem Research, Environment Canada, 105 McGill St., Montreal, Quebec H2Y 2E7 (Canada)
- INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)
Citation Formats
Gust, M, IRSTEA, UR MAEP, Laboratoire d'ecotoxicologie, 3 bis quai Chauveau, 69009 Lyon (France)], Gelinas, M, Fortier, M, Fournier, M, Gagne, F, and INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)].
In vitro immunotoxicity of environmentally representative antibiotics to the freshwater mussel Elliptio complanata.
United Kingdom: N. p.,
2012.
Web.
doi:10.1016/J.ENVPOL.2012.05.020.
Gust, M, IRSTEA, UR MAEP, Laboratoire d'ecotoxicologie, 3 bis quai Chauveau, 69009 Lyon (France)], Gelinas, M, Fortier, M, Fournier, M, Gagne, F, & INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)].
In vitro immunotoxicity of environmentally representative antibiotics to the freshwater mussel Elliptio complanata.
United Kingdom.
https://doi.org/10.1016/J.ENVPOL.2012.05.020
Gust, M, IRSTEA, UR MAEP, Laboratoire d'ecotoxicologie, 3 bis quai Chauveau, 69009 Lyon (France)], Gelinas, M, Fortier, M, Fournier, M, Gagne, F, and INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)].
2012.
"In vitro immunotoxicity of environmentally representative antibiotics to the freshwater mussel Elliptio complanata."
United Kingdom.
https://doi.org/10.1016/J.ENVPOL.2012.05.020.
@misc{etde_22068056,
title = {In vitro immunotoxicity of environmentally representative antibiotics to the freshwater mussel Elliptio complanata}
author = {Gust, M, IRSTEA, UR MAEP, Laboratoire d'ecotoxicologie, 3 bis quai Chauveau, 69009 Lyon (France)], Gelinas, M, Fortier, M, Fournier, M, Gagne, F, and INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)]}
abstractNote = {The separate and combined in vitro toxic effects of antibiotics (ciprofloxacin, erythromycin, novobiocin, oxytetracycline, sulfamethazole and trimethoprim) commonly found in urban wastewater effluents were assessed on the immune parameters of Elliptio complanata at environmentally relevant concentrations. The observed responses were then compared to those produced by the physicochemical-treated wastewater effluent of a major city before and after the removal of microorganisms. Most of the selected antibiotics, separately and as mixture, induced changes in immune responses. The removal of microorganisms and fine particles from the effluent increased or decreased the resulting immunotoxic effects, depending of the observed parameter. The immunotoxic effects of erythromycin, sulfamethoxazole and trimethoprim were closely associated to the antibiotic mixture and the filtered effluent. In conclusion, the data revealed that the removal of fine particles and microorganisms from municipal effluents can alter the toxic nature of the effluent that is closely associated with the cumulative effects of antibiotics. - Highlights: Black-Right-Pointing-Pointer Environmental concentrations of antibiotics induce the immune response in mussels. Black-Right-Pointing-Pointer Antibiotic mixture also modulate the immune response. Black-Right-Pointing-Pointer Urban effluent, both filtered and unfiltered also increase the immune response. Black-Right-Pointing-Pointer Filtered effluent, antibiotic mixture and 3 antibiotics induced similar responses. - Environmentally relevant concentration of antibiotics and filtered urban effluent similarly modulate the in vitro immune response of mussels' hemocytes.}
doi = {10.1016/J.ENVPOL.2012.05.020}
journal = []
volume = {169}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Oct}
}
title = {In vitro immunotoxicity of environmentally representative antibiotics to the freshwater mussel Elliptio complanata}
author = {Gust, M, IRSTEA, UR MAEP, Laboratoire d'ecotoxicologie, 3 bis quai Chauveau, 69009 Lyon (France)], Gelinas, M, Fortier, M, Fournier, M, Gagne, F, and INRS - Institut Armand-Frappier, 531 Blvd. des Prairies, Laval, Quebec H7V 1B7 (Canada)]}
abstractNote = {The separate and combined in vitro toxic effects of antibiotics (ciprofloxacin, erythromycin, novobiocin, oxytetracycline, sulfamethazole and trimethoprim) commonly found in urban wastewater effluents were assessed on the immune parameters of Elliptio complanata at environmentally relevant concentrations. The observed responses were then compared to those produced by the physicochemical-treated wastewater effluent of a major city before and after the removal of microorganisms. Most of the selected antibiotics, separately and as mixture, induced changes in immune responses. The removal of microorganisms and fine particles from the effluent increased or decreased the resulting immunotoxic effects, depending of the observed parameter. The immunotoxic effects of erythromycin, sulfamethoxazole and trimethoprim were closely associated to the antibiotic mixture and the filtered effluent. In conclusion, the data revealed that the removal of fine particles and microorganisms from municipal effluents can alter the toxic nature of the effluent that is closely associated with the cumulative effects of antibiotics. - Highlights: Black-Right-Pointing-Pointer Environmental concentrations of antibiotics induce the immune response in mussels. Black-Right-Pointing-Pointer Antibiotic mixture also modulate the immune response. Black-Right-Pointing-Pointer Urban effluent, both filtered and unfiltered also increase the immune response. Black-Right-Pointing-Pointer Filtered effluent, antibiotic mixture and 3 antibiotics induced similar responses. - Environmentally relevant concentration of antibiotics and filtered urban effluent similarly modulate the in vitro immune response of mussels' hemocytes.}
doi = {10.1016/J.ENVPOL.2012.05.020}
journal = []
volume = {169}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Oct}
}