You need JavaScript to view this

Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries

Abstract

Effective therapy for chronic radiation injuries, such as ulcers, is prone to infection. Stiffness is expected since the therapeutic radiation often involves wider and deeper tissues and often requires extensive debridement and reconstruction, which are not sometimes appropriate for elderly and compromised hosts. Autologous adipose-derived regenerative cells (ADRCs) are highly yielding, forming relatively elderly aged consecutive 10 cases, 63.6{+-}14.9 y (52-89 y), with mean radiation dose of 75.0{+-}35.4 Gy (50-120 Gy) were included with at least 10-month follow-up. Minimal debridement and ADRC injection in the wound bed and margin along with the injection of mixture of fat and ADRCs in the periphery were tested for efficacy and regenerated tissue quality by clinically as well as imaging by computed tomography and magnetic resonance imaging. Uncultured ADRCs of 1.6{+-}1.3 x 10{sup 7} cells were obtained. All cases healed uneventfully after 6.6{+-}3.2 weeks (2-10 weeks) post-operatively. The done site morbidity was negligible and without major complications, such as paralysis or massive haematoma. The regenerated tissue quality was significantly superior to the pre-operative one and the mixture of fat and ADRCs connected to the intact tissue was very soft and pliable. Mean follow-up at 1.9{+-}0.8 y (0.9-2.9 y) revealed no recurrence or new ulceration  More>>
Authors:
Akita, S; Yoshimoto, H; [1]  Ohtsuru, A; [2]  Hirano, A; [1]  Yamashita, S; [2]  Dept. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. School of Medicine, Nagasaki (Japan)]
  1. Div. of Plastic and Reconstructive Surgery, Dept. of Developmental and Reconstructive Medicine, Nagasaki Univ., Graduate School of Biomedical and Sciences, Nagasaki (Japan)
  2. Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki Univ. Hospital, Nagasaki (Japan)
Publication Date:
Jul 01, 2012
Product Type:
Journal Article
Resource Relation:
Journal Name: Radiation Protection Dosimetry; Journal Volume: 151; Journal Issue: 4; Conference: 13. coordination and planning meeting of the WHO-REMPAN: Radiation emergency medical preparedness and assistance network, Nagasaki (Japan), 16-18 Feb 2011; Other Information: Country of input: France; 19 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; 61 RADIATION PROTECTION AND DOSIMETRY; COMPUTERIZED TOMOGRAPHY; ELDERLY PEOPLE; NMR IMAGING; RADIATION DOSES; RADIATION INJURIES; THERAPY; WOUNDS
OSTI ID:
22032422
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0144-8420; TRN: GB12V1775120905
Availability:
Available from doi: http://dx.doi.org/10.1093/rpd/ncs176
Submitting Site:
INIS
Size:
page(s) 656-660
Announcement Date:
Feb 01, 2013

Citation Formats

Akita, S, Yoshimoto, H, Ohtsuru, A, Hirano, A, Yamashita, S, and Dept. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. School of Medicine, Nagasaki (Japan)]. Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries. United Kingdom: N. p., 2012. Web. doi:10.1093/RPD/NCS176.
Akita, S, Yoshimoto, H, Ohtsuru, A, Hirano, A, Yamashita, S, & Dept. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. School of Medicine, Nagasaki (Japan)]. Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries. United Kingdom. doi:10.1093/RPD/NCS176.
Akita, S, Yoshimoto, H, Ohtsuru, A, Hirano, A, Yamashita, S, and Dept. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. School of Medicine, Nagasaki (Japan)]. 2012. "Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries." United Kingdom. doi:10.1093/RPD/NCS176. https://www.osti.gov/servlets/purl/10.1093/RPD/NCS176.
@misc{etde_22032422,
title = {Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries}
author = {Akita, S, Yoshimoto, H, Ohtsuru, A, Hirano, A, Yamashita, S, and Dept. of Molecular Medicine, Atomic Bomb Disease Inst., Nagasaki Univ. School of Medicine, Nagasaki (Japan)]}
abstractNote = {Effective therapy for chronic radiation injuries, such as ulcers, is prone to infection. Stiffness is expected since the therapeutic radiation often involves wider and deeper tissues and often requires extensive debridement and reconstruction, which are not sometimes appropriate for elderly and compromised hosts. Autologous adipose-derived regenerative cells (ADRCs) are highly yielding, forming relatively elderly aged consecutive 10 cases, 63.6{+-}14.9 y (52-89 y), with mean radiation dose of 75.0{+-}35.4 Gy (50-120 Gy) were included with at least 10-month follow-up. Minimal debridement and ADRC injection in the wound bed and margin along with the injection of mixture of fat and ADRCs in the periphery were tested for efficacy and regenerated tissue quality by clinically as well as imaging by computed tomography and magnetic resonance imaging. Uncultured ADRCs of 1.6{+-}1.3 x 10{sup 7} cells were obtained. All cases healed uneventfully after 6.6{+-}3.2 weeks (2-10 weeks) post-operatively. The done site morbidity was negligible and without major complications, such as paralysis or massive haematoma. The regenerated tissue quality was significantly superior to the pre-operative one and the mixture of fat and ADRCs connected to the intact tissue was very soft and pliable. Mean follow-up at 1.9{+-}0.8 y (0.9-2.9 y) revealed no recurrence or new ulceration after treatment. Thus, the ADRCs treatment for decades-long radiation injuries is effective, safe and improves the quality of wounds. (authors)}
doi = {10.1093/RPD/NCS176}
journal = {Radiation Protection Dosimetry}
issue = {4}
volume = {151}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Jul}
}