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Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)

Abstract

Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration range of Triclosan through fertilization assay (reproductive success), embryo-larval development assay (early life stage) and physiological stress (Neutral Red Retention Time assay - NRRT) (adult stage) in the marine sentinel organism Perna perna. The mean inhibition concentrations for fertilization (IC{sub 50} = 0.490 mg L{sup -1}) and embryo-larval development (IC{sub 50} = 0.135 mg L{sup -1}) tests were above environmental relevant concentrations (ng L{sup -1}) given by previous studies. Differently, significant reduction on NRRT results was found at 12 ng L{sup -1}, demonstrating the current risk of the continuous introduction of Triclosan into aquatic environments, and the need of ecotoxicological studies oriented by the mechanism of action of the compound. - Highlights: Black-Right-Pointing-Pointer Triclosan causes biological adverse effects at environmental relevant concentrations. Black-Right-Pointing-Pointer Mechanisms of action oriented assays were more sensitive to detect biological damages. Black-Right-Pointing-Pointer Currently there is environmental risks concerned Triclosan in aquatic ecosystems. - Triclosan causes biological  More>>
Publication Date:
Sep 15, 2012
Product Type:
Journal Article
Resource Relation:
Journal Name: Environmental Pollution (1987); Journal Volume: . 168; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Subject:
54 ENVIRONMENTAL SCIENCES; AQUATIC ECOSYSTEMS; BIOLOGICAL EFFECTS; DRUGS; EMBRYOS; ENVIRONMENT; ENVIRONMENTAL IMPACTS; FERTILIZATION; LARVAE; MUSSELS; ORGANIC CHLORINE COMPOUNDS; PHENOLS; PYRAZINES; TOXICITY
OSTI ID:
22029337
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0269-7491; CODEN: ENPOEK; Other: PII: S0269-7491(12)00218-7; TRN: GB12R6916117903
Availability:
Available from http://dx.doi.org/10.1016/j.envpol.2012.04.024
Submitting Site:
INIS
Size:
page(s) 145-150
Announcement Date:
Jan 29, 2013

Citation Formats

Sanzi Cortez, Fernando, E-mail: lecotox@unisanta.br [Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, 05508-000 Sao Paulo, SP (Brazil), Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil)], Dias Seabra Pereira, Camilo, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Ramos Santos, Aldo Ramos, Cesar, Augusto, Choueri, Rodrigo Brasil, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Martini, Gisela de Assis, and Bohrer-Morel, Maria Beatriz. Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758). United Kingdom: N. p., 2012. Web. doi:10.1016/J.ENVPOL.2012.04.024.
Sanzi Cortez, Fernando, E-mail: lecotox@unisanta.br [Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, 05508-000 Sao Paulo, SP (Brazil), Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil)], Dias Seabra Pereira, Camilo, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Ramos Santos, Aldo Ramos, Cesar, Augusto, Choueri, Rodrigo Brasil, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Martini, Gisela de Assis, & Bohrer-Morel, Maria Beatriz. Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758). United Kingdom. doi:10.1016/J.ENVPOL.2012.04.024.
Sanzi Cortez, Fernando, E-mail: lecotox@unisanta.br [Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, 05508-000 Sao Paulo, SP (Brazil), Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil)], Dias Seabra Pereira, Camilo, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Ramos Santos, Aldo Ramos, Cesar, Augusto, Choueri, Rodrigo Brasil, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Martini, Gisela de Assis, and Bohrer-Morel, Maria Beatriz. 2012. "Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)." United Kingdom. doi:10.1016/J.ENVPOL.2012.04.024. https://www.osti.gov/servlets/purl/10.1016/J.ENVPOL.2012.04.024.
@misc{etde_22029337,
title = {Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)}
author = {Sanzi Cortez, Fernando, E-mail: lecotox@unisanta.br [Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, 05508-000 Sao Paulo, SP (Brazil), Laboratorio de Ecotoxicologia, Universidade Santa Cecilia, 11045-907 Santos, SP (Brazil)], Dias Seabra Pereira, Camilo, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Ramos Santos, Aldo Ramos, Cesar, Augusto, Choueri, Rodrigo Brasil, Instituto do Mar, Universidade Federal de Sao Paulo, 11030-400 Santos, SP (Brazil)], Martini, Gisela de Assis, and Bohrer-Morel, Maria Beatriz}
abstractNote = {Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration range of Triclosan through fertilization assay (reproductive success), embryo-larval development assay (early life stage) and physiological stress (Neutral Red Retention Time assay - NRRT) (adult stage) in the marine sentinel organism Perna perna. The mean inhibition concentrations for fertilization (IC{sub 50} = 0.490 mg L{sup -1}) and embryo-larval development (IC{sub 50} = 0.135 mg L{sup -1}) tests were above environmental relevant concentrations (ng L{sup -1}) given by previous studies. Differently, significant reduction on NRRT results was found at 12 ng L{sup -1}, demonstrating the current risk of the continuous introduction of Triclosan into aquatic environments, and the need of ecotoxicological studies oriented by the mechanism of action of the compound. - Highlights: Black-Right-Pointing-Pointer Triclosan causes biological adverse effects at environmental relevant concentrations. Black-Right-Pointing-Pointer Mechanisms of action oriented assays were more sensitive to detect biological damages. Black-Right-Pointing-Pointer Currently there is environmental risks concerned Triclosan in aquatic ecosystems. - Triclosan causes biological adverse effects at environmentally relevant concentrations.}
doi = {10.1016/J.ENVPOL.2012.04.024}
journal = {Environmental Pollution (1987)}
volume = {. 168}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Sep}
}