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Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture

Abstract

Co-contamination of ligand-like antibiotics (e.g., tetracyclines and quinolones) and heavy metals prevails in the environment, and thus the complexation between them is involved in environmental risks of antibiotics. To understand toxicological significance of the complex, effects of metal coordination on antibiotics' toxicity were investigated. The complexation of two antibiotics, oxytetracycline and ciprofloxacin, with three heavy metals, copper, zinc, and cadmium, was verified by spectroscopic techniques. The antibiotics bound metals via multiple coordination sites and rendered a mixture of various complexation speciations. Toxicity analysis indicated that metal coordination did modify the toxicity of the antibiotics and that antibiotic, metal, and their complex acted primarily as concentration addition. Comparison of EC{sub 50} values revealed that the complex commonly was highest toxic and predominately correlated in toxicity to the mixture. Finally, environmental scenario analysis demonstrated that ignoring complexation would improperly classify environmental risks of the antibiotics. - Highlights: Black-Right-Pointing-Pointer The complex of antibiotic with metal is a mixture of various complexation modes. Black-Right-Pointing-Pointer Antibiotic and metal act as various combined interactions when their complexation is ignored. Black-Right-Pointing-Pointer Antibiotic, metal, and their complex act as concentration addition interaction. Black-Right-Pointing-Pointer Complex commonly is the highest toxicant. Black-Right-Pointing-Pointer Neglecting complexation renders improper classification of risks for  More>>
Authors:
Yu, Zhang; [1]  Cai Xiyun, E-mail: xiyuncai@dlut.edu.cn; [1]  Xianming, Lang; [2]  Xianliang, Qiao; Xuehua, Li; Jingwen, Chen [1] 
  1. Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024 (China)
  2. Liaoning Academy of Environmental Sciences, Shenyang 110031 (China)
Publication Date:
Jul 15, 2012
Product Type:
Journal Article
Resource Relation:
Journal Name: Environmental Pollution (1987); Journal Volume: . 166; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Subject:
54 ENVIRONMENTAL SCIENCES; CADMIUM; CADMIUM COMPLEXES; COPPER; COPPER COMPLEXES; ENVIRONMENT; HAZARDS; HEAVY METALS; INTERACTIONS; LIGANDS; MIXTURES; OXYTETRACYCLINE; TOXICITY; WATER POLLUTION; ZINC; ZINC COMPLEXES
OSTI ID:
22029273
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0269-7491; CODEN: ENPOEK; Other: PII: S0269-7491(12)00121-2; TRN: GB12R6852117839
Availability:
Available from http://dx.doi.org/10.1016/j.envpol.2012.03.009
Submitting Site:
INIS
Size:
page(s) 48-56
Announcement Date:
Jan 31, 2013

Citation Formats

Yu, Zhang, Cai Xiyun, E-mail: xiyuncai@dlut.edu.cn, Xianming, Lang, Xianliang, Qiao, Xuehua, Li, and Jingwen, Chen. Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture. United Kingdom: N. p., 2012. Web. doi:10.1016/J.ENVPOL.2012.03.009.
Yu, Zhang, Cai Xiyun, E-mail: xiyuncai@dlut.edu.cn, Xianming, Lang, Xianliang, Qiao, Xuehua, Li, & Jingwen, Chen. Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture. United Kingdom. doi:10.1016/J.ENVPOL.2012.03.009.
Yu, Zhang, Cai Xiyun, E-mail: xiyuncai@dlut.edu.cn, Xianming, Lang, Xianliang, Qiao, Xuehua, Li, and Jingwen, Chen. 2012. "Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture." United Kingdom. doi:10.1016/J.ENVPOL.2012.03.009. https://www.osti.gov/servlets/purl/10.1016/J.ENVPOL.2012.03.009.
@misc{etde_22029273,
title = {Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: Complexation versus mixture}
author = {Yu, Zhang, Cai Xiyun, E-mail: xiyuncai@dlut.edu.cn, Xianming, Lang, Xianliang, Qiao, Xuehua, Li, and Jingwen, Chen}
abstractNote = {Co-contamination of ligand-like antibiotics (e.g., tetracyclines and quinolones) and heavy metals prevails in the environment, and thus the complexation between them is involved in environmental risks of antibiotics. To understand toxicological significance of the complex, effects of metal coordination on antibiotics' toxicity were investigated. The complexation of two antibiotics, oxytetracycline and ciprofloxacin, with three heavy metals, copper, zinc, and cadmium, was verified by spectroscopic techniques. The antibiotics bound metals via multiple coordination sites and rendered a mixture of various complexation speciations. Toxicity analysis indicated that metal coordination did modify the toxicity of the antibiotics and that antibiotic, metal, and their complex acted primarily as concentration addition. Comparison of EC{sub 50} values revealed that the complex commonly was highest toxic and predominately correlated in toxicity to the mixture. Finally, environmental scenario analysis demonstrated that ignoring complexation would improperly classify environmental risks of the antibiotics. - Highlights: Black-Right-Pointing-Pointer The complex of antibiotic with metal is a mixture of various complexation modes. Black-Right-Pointing-Pointer Antibiotic and metal act as various combined interactions when their complexation is ignored. Black-Right-Pointing-Pointer Antibiotic, metal, and their complex act as concentration addition interaction. Black-Right-Pointing-Pointer Complex commonly is the highest toxicant. Black-Right-Pointing-Pointer Neglecting complexation renders improper classification of risks for antibiotics. - Antibiotic, heavy metal and their complex act primarily as concentration addition interaction and the complex commonly is highest toxic.}
doi = {10.1016/J.ENVPOL.2012.03.009}
journal = {Environmental Pollution (1987)}
volume = {. 166}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Jul}
}