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Microwave-assisted phenytoine synthesis: proposed practical class for undergraduate students; Sintese da fenitoina assistida por micro-ondas: proposta de aula pratica para alunos de graduacao

Abstract

Microwave synthesis is considered a breakthrough in the field of chemistry due to its benefits over conventional heating methods. We describe, for the first time, the total synthesis of phenytoine adapted for a microwave reactor, proposed as an experiment for undergraduate courses. When carried out with microwaves, the synthetic route provided phenytoine in 6 min and 30 s, while for conventional heating the total time was 170 min. The experiment also involves rapid identification of compounds by TLC, {sup 1}H NMR, FT-IR and melting points determination. (author)
Authors:
Konrath, Eduardo L; Piedade, Maristela; Eifler-Lima, Vera Lucia, E-mail: edukonrath@yahoo.com.br [1] 
  1. Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Fac. de Farmacia. Dept. de Producao de Materia-Prima
Publication Date:
Jul 01, 2012
Product Type:
Journal Article
Resource Relation:
Journal Name: Quimica Nova; Journal Volume: 35; Journal Issue: 9
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACETATES; BENZALDEHYDE; BENZOIC ACID; DRUGS; HYDROGEN 1; INFRARED SPECTRA; MELTING POINTS; MICROWAVE RADIATION; NMR SPECTRA; OXIDATION; STRUCTURAL CHEMICAL ANALYSIS
OSTI ID:
22028876
Country of Origin:
Brazil
Language:
Portuguese
Other Identifying Numbers:
Journal ID: ISSN 0100-4042; TRN: BR12V3064117005
Availability:
Available from http://www.scielo.br/pdf/qn/v35n9/v35n9a33.pdf
Submitting Site:
BRN
Size:
page(s) 1887-1890
Announcement Date:
Jan 31, 2013

Citation Formats

Konrath, Eduardo L, Piedade, Maristela, and Eifler-Lima, Vera Lucia, E-mail: edukonrath@yahoo.com.br. Microwave-assisted phenytoine synthesis: proposed practical class for undergraduate students; Sintese da fenitoina assistida por micro-ondas: proposta de aula pratica para alunos de graduacao. Brazil: N. p., 2012. Web. doi:10.1590/S0100-40422012000900033.
Konrath, Eduardo L, Piedade, Maristela, & Eifler-Lima, Vera Lucia, E-mail: edukonrath@yahoo.com.br. Microwave-assisted phenytoine synthesis: proposed practical class for undergraduate students; Sintese da fenitoina assistida por micro-ondas: proposta de aula pratica para alunos de graduacao. Brazil. doi:10.1590/S0100-40422012000900033.
Konrath, Eduardo L, Piedade, Maristela, and Eifler-Lima, Vera Lucia, E-mail: edukonrath@yahoo.com.br. 2012. "Microwave-assisted phenytoine synthesis: proposed practical class for undergraduate students; Sintese da fenitoina assistida por micro-ondas: proposta de aula pratica para alunos de graduacao." Brazil. doi:10.1590/S0100-40422012000900033. https://www.osti.gov/servlets/purl/10.1590/S0100-40422012000900033.
@misc{etde_22028876,
title = {Microwave-assisted phenytoine synthesis: proposed practical class for undergraduate students; Sintese da fenitoina assistida por micro-ondas: proposta de aula pratica para alunos de graduacao}
author = {Konrath, Eduardo L, Piedade, Maristela, and Eifler-Lima, Vera Lucia, E-mail: edukonrath@yahoo.com.br}
abstractNote = {Microwave synthesis is considered a breakthrough in the field of chemistry due to its benefits over conventional heating methods. We describe, for the first time, the total synthesis of phenytoine adapted for a microwave reactor, proposed as an experiment for undergraduate courses. When carried out with microwaves, the synthetic route provided phenytoine in 6 min and 30 s, while for conventional heating the total time was 170 min. The experiment also involves rapid identification of compounds by TLC, {sup 1}H NMR, FT-IR and melting points determination. (author)}
doi = {10.1590/S0100-40422012000900033}
journal = {Quimica Nova}
issue = {9}
volume = {35}
journal type = {AC}
place = {Brazil}
year = {2012}
month = {Jul}
}