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Phytochemicals with radioprotection and radio-sensitizing potential

Conference:

Abstract

Ionizing radiation induces DNA damage and are harmful to mankind. They act through free radical generation, which target the double bonds of all cellular macromolecules. The radiation damage may be classified as probabilistic or deterministic, depending on the dose of radiation exposure. Since radiation affects multiple organs so those drugs which protect many organs, would be more beneficial. In this process herbal extracts, which are cocktail of several phyto-chemicals, would be more promising. Initially sulphur containing bio-molecules were identified as radio-protector, but now many secondary metabolites from plant kingdom, have been reported to be radio-protective. They have different mechanism of action, but most of them either prevent the FR induced DNA damage or accelerate the DNA repair process. Aminofostine, WR-2721, 159243, 2926 are some of the examples. However they have limited use because of associated cytotoxicity. Eicosanoids, topoisornerase inhibitors (e.g. camptothecin, topotecan), and the hypoxia-activated anthraquinone AQ4N have shown radioprotecting potential. Several plant products, derived from Tulsi, Vinca alkaloids, taxans, turmeric, Rubia cordifolia, Semecarpus anacardium and several plants rich in polyphenols and flavones have shown hemotherapeutic potential. Similarly, Hippophae, rhodiola imbricata, Podophyllum hexandrum, Ocimum sancturn, Plumbago zeylanica etc have shown radioprotection. Rubia cordifolia has shown both chemotherapeutic and radioprotective property  More>>
Authors:
Tripathi, Yamini B., E-mail: yaminiok@yahoo.com [1] 
  1. Dept. of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi (India)
Publication Date:
Jul 01, 2012
Product Type:
Conference
Resource Relation:
Conference: International conference on emerging frontiers and challenges in radiation biology, Bikaner (India), 24-25 Jan 2012; Related Information: In: Proceedings of the international conference on emerging frontiers and challenges in radiation biology: abstracts| by Purohit, R.K.; Chakrawarti, Aruna; Agarwal, Manisha (eds.) [Radiation Biology Laboratory, Department of Zoology, Govt. Dungar College, Bikaner (India)]; Saini, Vipin (ed.) [Dept. of Geography, Govt. Dungar College, Bikaner (India)]; Arora, Anil (ed.) [Dept. of Botany, Govt. Dungar College, Bikaner (India)]| 178 p.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; DNA DAMAGES; DNA REPAIR; MEDICINAL PLANTS; RADIATION DOSES; RADIOPROTECTIVE SUBSTANCES; RADIOSENSITIVITY EFFECTS
OSTI ID:
22026941
Research Organizations:
Indian Society for Radiation Biology (India); Department of Zoology, Government Dungar College, Bikaner (India); Maharaja Ganga Singh University, Bikaner (India)
Country of Origin:
India
Language:
English
Other Identifying Numbers:
TRN: IN1201947115192
Submitting Site:
INIS
Size:
page(s) 35
Announcement Date:
Jan 24, 2013

Conference:

Citation Formats

Tripathi, Yamini B., E-mail: yaminiok@yahoo.com. Phytochemicals with radioprotection and radio-sensitizing potential. India: N. p., 2012. Web.
Tripathi, Yamini B., E-mail: yaminiok@yahoo.com. Phytochemicals with radioprotection and radio-sensitizing potential. India.
Tripathi, Yamini B., E-mail: yaminiok@yahoo.com. 2012. "Phytochemicals with radioprotection and radio-sensitizing potential." India.
@misc{etde_22026941,
title = {Phytochemicals with radioprotection and radio-sensitizing potential}
author = {Tripathi, Yamini B., E-mail: yaminiok@yahoo.com}
abstractNote = {Ionizing radiation induces DNA damage and are harmful to mankind. They act through free radical generation, which target the double bonds of all cellular macromolecules. The radiation damage may be classified as probabilistic or deterministic, depending on the dose of radiation exposure. Since radiation affects multiple organs so those drugs which protect many organs, would be more beneficial. In this process herbal extracts, which are cocktail of several phyto-chemicals, would be more promising. Initially sulphur containing bio-molecules were identified as radio-protector, but now many secondary metabolites from plant kingdom, have been reported to be radio-protective. They have different mechanism of action, but most of them either prevent the FR induced DNA damage or accelerate the DNA repair process. Aminofostine, WR-2721, 159243, 2926 are some of the examples. However they have limited use because of associated cytotoxicity. Eicosanoids, topoisornerase inhibitors (e.g. camptothecin, topotecan), and the hypoxia-activated anthraquinone AQ4N have shown radioprotecting potential. Several plant products, derived from Tulsi, Vinca alkaloids, taxans, turmeric, Rubia cordifolia, Semecarpus anacardium and several plants rich in polyphenols and flavones have shown hemotherapeutic potential. Similarly, Hippophae, rhodiola imbricata, Podophyllum hexandrum, Ocimum sancturn, Plumbago zeylanica etc have shown radioprotection. Rubia cordifolia has shown both chemotherapeutic and radioprotective property in rats and A-431 cells. Similarly Semecarpus anacardium extract has shown cell cycle arrest in DU-145 cells. (author)}
place = {India}
year = {2012}
month = {Jul}
}