Abstract
Ionizing radiation is known to produce oxidative stress through the generation of ROS leading to a variety of DNA lesions. However, the most dangerous DNA lesions which are responsible for the origin of lethal effects, mutagenesis, genomic instability and carcinogenesis are the DSBs. During recent years efforts are being made to identify phytochemicals or other naturally occurring compounds which can reduce the harmful effect of radiation during accidental exposure or prevent normal tissue injury during radiotherapy. In present study, we have investigated the protective role of curcumin, taurine, apigenin and kaempferol against radiation-induced oxidative damage in mice. Groups of mice were fed 1 % of curcumin in diet for three weeks. Similarly other groups of mice were injected i.p. with 50 mg/kg body weight of taurine for five consecutive days. Other four groups of mice were injected i.p. with apigenin (10.8 mg/kg BW and 21.6 mg/kg BW), kaempferol (14.3 mg/kg BW and 28.6 mg/kg BW). After the completion of the treatment mice pre-treated with curcumin, taurine, apigenin and kaempferol were exposed to 2 or 3 Gy of gamma rays. Immediately after irradiation, alkaline comet assay was performed using standard procedures. Twenty four post radiation exposure mice were sacrificed for micronucleus
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Jayakumar, S;
Bhilwade, H N;
Chaubey, R.C., E-mail: rcchaubey@yahoo.com
[1]
- Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai (India)
Citation Formats
Jayakumar, S, Bhilwade, H N, and Chaubey, R.C., E-mail: rcchaubey@yahoo.com.
In vivo radioprotective effect of curcumin, taurine, apigenin and kampferol on DNA damage in mouse.
India: N. p.,
2012.
Web.
Jayakumar, S, Bhilwade, H N, & Chaubey, R.C., E-mail: rcchaubey@yahoo.com.
In vivo radioprotective effect of curcumin, taurine, apigenin and kampferol on DNA damage in mouse.
India.
Jayakumar, S, Bhilwade, H N, and Chaubey, R.C., E-mail: rcchaubey@yahoo.com.
2012.
"In vivo radioprotective effect of curcumin, taurine, apigenin and kampferol on DNA damage in mouse."
India.
@misc{etde_22026929,
title = {In vivo radioprotective effect of curcumin, taurine, apigenin and kampferol on DNA damage in mouse}
author = {Jayakumar, S, Bhilwade, H N, and Chaubey, R.C., E-mail: rcchaubey@yahoo.com}
abstractNote = {Ionizing radiation is known to produce oxidative stress through the generation of ROS leading to a variety of DNA lesions. However, the most dangerous DNA lesions which are responsible for the origin of lethal effects, mutagenesis, genomic instability and carcinogenesis are the DSBs. During recent years efforts are being made to identify phytochemicals or other naturally occurring compounds which can reduce the harmful effect of radiation during accidental exposure or prevent normal tissue injury during radiotherapy. In present study, we have investigated the protective role of curcumin, taurine, apigenin and kaempferol against radiation-induced oxidative damage in mice. Groups of mice were fed 1 % of curcumin in diet for three weeks. Similarly other groups of mice were injected i.p. with 50 mg/kg body weight of taurine for five consecutive days. Other four groups of mice were injected i.p. with apigenin (10.8 mg/kg BW and 21.6 mg/kg BW), kaempferol (14.3 mg/kg BW and 28.6 mg/kg BW). After the completion of the treatment mice pre-treated with curcumin, taurine, apigenin and kaempferol were exposed to 2 or 3 Gy of gamma rays. Immediately after irradiation, alkaline comet assay was performed using standard procedures. Twenty four post radiation exposure mice were sacrificed for micronucleus test.}
place = {India}
year = {2012}
month = {Jul}
}
title = {In vivo radioprotective effect of curcumin, taurine, apigenin and kampferol on DNA damage in mouse}
author = {Jayakumar, S, Bhilwade, H N, and Chaubey, R.C., E-mail: rcchaubey@yahoo.com}
abstractNote = {Ionizing radiation is known to produce oxidative stress through the generation of ROS leading to a variety of DNA lesions. However, the most dangerous DNA lesions which are responsible for the origin of lethal effects, mutagenesis, genomic instability and carcinogenesis are the DSBs. During recent years efforts are being made to identify phytochemicals or other naturally occurring compounds which can reduce the harmful effect of radiation during accidental exposure or prevent normal tissue injury during radiotherapy. In present study, we have investigated the protective role of curcumin, taurine, apigenin and kaempferol against radiation-induced oxidative damage in mice. Groups of mice were fed 1 % of curcumin in diet for three weeks. Similarly other groups of mice were injected i.p. with 50 mg/kg body weight of taurine for five consecutive days. Other four groups of mice were injected i.p. with apigenin (10.8 mg/kg BW and 21.6 mg/kg BW), kaempferol (14.3 mg/kg BW and 28.6 mg/kg BW). After the completion of the treatment mice pre-treated with curcumin, taurine, apigenin and kaempferol were exposed to 2 or 3 Gy of gamma rays. Immediately after irradiation, alkaline comet assay was performed using standard procedures. Twenty four post radiation exposure mice were sacrificed for micronucleus test.}
place = {India}
year = {2012}
month = {Jul}
}