Abstract
Using radiolytic experiments hydroxyl radical (main reactant in advanced oxidation processes) was shown to effectively destroy paracetamol molecules. The basic reaction is attachment to the ring. The hydroxy-cyclohexadienyl radical produced in the further reactions may transform to hydroxylated paracetamol derivatives or to quinone type molecules and acetamide. The initial efficiency of aromatic ring destruction in the absence of dissolved O{sub 2} is c.a. 10%. The efficiency is 2-3 times higher in the presence of O{sub 2} due to its reaction with intermediate hydroxy-cyclohexadienyl radical and the subsequent ring destruction reactions through peroxi radical. Upon irradiation the toxicity of solutions at low doses increases with the dose and then at higher doses it decreases. This is due to formation of compounds with higher toxicity than paracetamol (e.g. acetamide, hidroquinone). These products, however, are highly sensitive to irradiation and degrade easily. - Highlights: Black-Right-Pointing-Pointer Paracetamol is easily degraded in aqueous solution by low dose irradiation. Black-Right-Pointing-Pointer Main degradation products are hydroxylated molecules, acetamide and hydroquinone. Black-Right-Pointing-Pointer Toxicity of solutions goes through a maximum as a function of dose.
Szabo, Laszlo;
[1]
Budapest University of Technology and Economics, Budapest (Hungary)];
Toth, Tuende;
[2]
Homlok, Renata;
[1]
Takacs, Erzsebet;
[1]
Wojnarovits, Laszlo
[1]
- Institute of Isotopes, Hungarian Academy of Sciences, Budapest (Hungary)
- Budapest University of Technology and Economics, Budapest (Hungary)
Citation Formats
Szabo, Laszlo, Budapest University of Technology and Economics, Budapest (Hungary)], Toth, Tuende, Homlok, Renata, Takacs, Erzsebet, and Wojnarovits, Laszlo.
Radiolysis of paracetamol in dilute aqueous solution.
United Kingdom: N. p.,
2012.
Web.
doi:10.1016/J.RADPHYSCHEM.2011.11.036.
Szabo, Laszlo, Budapest University of Technology and Economics, Budapest (Hungary)], Toth, Tuende, Homlok, Renata, Takacs, Erzsebet, & Wojnarovits, Laszlo.
Radiolysis of paracetamol in dilute aqueous solution.
United Kingdom.
https://doi.org/10.1016/J.RADPHYSCHEM.2011.11.036
Szabo, Laszlo, Budapest University of Technology and Economics, Budapest (Hungary)], Toth, Tuende, Homlok, Renata, Takacs, Erzsebet, and Wojnarovits, Laszlo.
2012.
"Radiolysis of paracetamol in dilute aqueous solution."
United Kingdom.
https://doi.org/10.1016/J.RADPHYSCHEM.2011.11.036.
@misc{etde_22019789,
title = {Radiolysis of paracetamol in dilute aqueous solution}
author = {Szabo, Laszlo, Budapest University of Technology and Economics, Budapest (Hungary)], Toth, Tuende, Homlok, Renata, Takacs, Erzsebet, and Wojnarovits, Laszlo}
abstractNote = {Using radiolytic experiments hydroxyl radical (main reactant in advanced oxidation processes) was shown to effectively destroy paracetamol molecules. The basic reaction is attachment to the ring. The hydroxy-cyclohexadienyl radical produced in the further reactions may transform to hydroxylated paracetamol derivatives or to quinone type molecules and acetamide. The initial efficiency of aromatic ring destruction in the absence of dissolved O{sub 2} is c.a. 10%. The efficiency is 2-3 times higher in the presence of O{sub 2} due to its reaction with intermediate hydroxy-cyclohexadienyl radical and the subsequent ring destruction reactions through peroxi radical. Upon irradiation the toxicity of solutions at low doses increases with the dose and then at higher doses it decreases. This is due to formation of compounds with higher toxicity than paracetamol (e.g. acetamide, hidroquinone). These products, however, are highly sensitive to irradiation and degrade easily. - Highlights: Black-Right-Pointing-Pointer Paracetamol is easily degraded in aqueous solution by low dose irradiation. Black-Right-Pointing-Pointer Main degradation products are hydroxylated molecules, acetamide and hydroquinone. Black-Right-Pointing-Pointer Toxicity of solutions goes through a maximum as a function of dose.}
doi = {10.1016/J.RADPHYSCHEM.2011.11.036}
journal = []
issue = {9}
volume = {81}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Sep}
}
title = {Radiolysis of paracetamol in dilute aqueous solution}
author = {Szabo, Laszlo, Budapest University of Technology and Economics, Budapest (Hungary)], Toth, Tuende, Homlok, Renata, Takacs, Erzsebet, and Wojnarovits, Laszlo}
abstractNote = {Using radiolytic experiments hydroxyl radical (main reactant in advanced oxidation processes) was shown to effectively destroy paracetamol molecules. The basic reaction is attachment to the ring. The hydroxy-cyclohexadienyl radical produced in the further reactions may transform to hydroxylated paracetamol derivatives or to quinone type molecules and acetamide. The initial efficiency of aromatic ring destruction in the absence of dissolved O{sub 2} is c.a. 10%. The efficiency is 2-3 times higher in the presence of O{sub 2} due to its reaction with intermediate hydroxy-cyclohexadienyl radical and the subsequent ring destruction reactions through peroxi radical. Upon irradiation the toxicity of solutions at low doses increases with the dose and then at higher doses it decreases. This is due to formation of compounds with higher toxicity than paracetamol (e.g. acetamide, hidroquinone). These products, however, are highly sensitive to irradiation and degrade easily. - Highlights: Black-Right-Pointing-Pointer Paracetamol is easily degraded in aqueous solution by low dose irradiation. Black-Right-Pointing-Pointer Main degradation products are hydroxylated molecules, acetamide and hydroquinone. Black-Right-Pointing-Pointer Toxicity of solutions goes through a maximum as a function of dose.}
doi = {10.1016/J.RADPHYSCHEM.2011.11.036}
journal = []
issue = {9}
volume = {81}
journal type = {AC}
place = {United Kingdom}
year = {2012}
month = {Sep}
}