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Toxicity levels to humans during acute exposure to hydrogen fluoride - An update

Abstract

In March 1993, the Atomic Energy Control Board (AECB) commissioned and update of a 1984 review on the acute toxicity of hydrogen fluoride (HF). The study places particular emphasis on the effects of inhalation of gaseous HF and is divided into two main parts: a literature review and a lethal concentration (LC) estimation. The literature review summarizes data under four categories: animal studies, controlled human studies, community exposure, and industrial exposure. Data in these areas were critically reviewed for their relevance to lethal concentrations at LC{sub LO}, LC{sub 10} and LC{sub 50} levels that were derived in the 1984 report. In the last ten years, only one relevant animal study has been published. No new controlled human studies were found but a community exposure incident was reported. There were three new industrial/accidental exposures reported since 1984. Evaluation of new data does not change the lethal concentration estimates made in the 1984 report, but does indicate the absence of appropriate models to estimate the lethality of irritant and corrosive gases. In the last 10 years, much literature on the evaluation of major hazards has been published and suggests that such assessments are of growing political, economic and social importance. Numerous articles  More>>
Authors:
Publication Date:
Sep 01, 1995
Product Type:
Technical Report
Report Number:
INFO-0583
Reference Number:
SCA: 053003; PA: AIX-27:031313; EDB-96:070737; NTS-96:017790; SN: 96001578130
Resource Relation:
Other Information: PBD: Sep 1995
Subject:
05 NUCLEAR FUELS; HYDROFLUORIC ACID; ACUTE EXPOSURE; TOXICITY; ANIMALS; CANADIAN AECB; DOSE-RESPONSE RELATIONSHIPS; ENVIRONMENTAL EXPOSURE; INHALATION; PUBLIC HEALTH; URANIUM
OSTI ID:
217489
Research Organizations:
Atomic Energy Control Board, Ottawa, ON (Canada)
Country of Origin:
Canada
Language:
English
Other Identifying Numbers:
Other: ON: DE96620534; CNN: Project 4.142.1; TRN: CA9600004031313
Availability:
INIS; OSTI as DE96620534
Submitting Site:
INIS
Size:
44 p.
Announcement Date:

Citation Formats

Halton, D M. Toxicity levels to humans during acute exposure to hydrogen fluoride - An update. Canada: N. p., 1995. Web.
Halton, D M. Toxicity levels to humans during acute exposure to hydrogen fluoride - An update. Canada.
Halton, D M. 1995. "Toxicity levels to humans during acute exposure to hydrogen fluoride - An update." Canada.
@misc{etde_217489,
title = {Toxicity levels to humans during acute exposure to hydrogen fluoride - An update}
author = {Halton, D M}
abstractNote = {In March 1993, the Atomic Energy Control Board (AECB) commissioned and update of a 1984 review on the acute toxicity of hydrogen fluoride (HF). The study places particular emphasis on the effects of inhalation of gaseous HF and is divided into two main parts: a literature review and a lethal concentration (LC) estimation. The literature review summarizes data under four categories: animal studies, controlled human studies, community exposure, and industrial exposure. Data in these areas were critically reviewed for their relevance to lethal concentrations at LC{sub LO}, LC{sub 10} and LC{sub 50} levels that were derived in the 1984 report. In the last ten years, only one relevant animal study has been published. No new controlled human studies were found but a community exposure incident was reported. There were three new industrial/accidental exposures reported since 1984. Evaluation of new data does not change the lethal concentration estimates made in the 1984 report, but does indicate the absence of appropriate models to estimate the lethality of irritant and corrosive gases. In the last 10 years, much literature on the evaluation of major hazards has been published and suggests that such assessments are of growing political, economic and social importance. Numerous articles have been published on the acute toxicity of HF from skin contact and chronic toxicity from repeated airborne exposure. These publications offer important insights into the nature of HF toxicity. Several avenues of investigative research are suggested. (author). 55 refs., 4 tabs.}
place = {Canada}
year = {1995}
month = {Sep}
}