Abstract
Purpose: To analyze the relationship between mean absorbed dose to the pubic bone after pelvic radiotherapy for gynecological cancer and occurrence of pubic bone pain among long-term survivors. Methods and Materials: In an unselected, population-based study, we identified 823 long-term gynecological cancer survivors treated with pelvic radiotherapy during 1991-2003. For comparison, we used a non-radiation-treated control population of 478 matched women from the Swedish Population Register. Pain, intensity of pain, and functional impairment due to pain in the pubic bone were assessed with a study-specific postal questionnaire. Results: We analyzed data from 650 survivors (participation rate 79%) with median follow-up of 6.3 years (range, 2.3-15.0 years) along with 344 control women (participation rate, 72 %). Ten percent of the survivors were treated with radiotherapy; ninety percent with surgery plus radiotherapy. Brachytherapy was added in 81%. Complete treatment records were recovered for 538/650 survivors, with dose distribution data including dose-volume histograms over the pubic bone. Pubic bone pain was reported by 73 survivors (11%); 59/517 (11%) had been exposed to mean absorbed external beam doses <52.5 Gy to the pubic bone and 5/12 (42%) to mean absorbed external beam doses {>=}52.5 Gy. Thirty-three survivors reported pain affecting sleep, a 13-fold increased
More>>
Waldenstroem, Ann-Charlotte;
[1]
Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)];
Olsson, Caroline;
[1]
Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)];
Wilderaeng, Ulrica;
[1]
Dunberger, Gail;
Lind, Helena;
[2]
Al-Abany, Massoud;
[2]
Department of Hospital Physics, Karolinska University Hospital, Stockholm (Sweden)];
Palm, Asa;
[3]
Avall-Lundqvist, Elisabeth;
[4]
Johansson, Karl-Axel;
[3]
Steineck, Gunnar;
[1]
Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)]
- Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)
- Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)
- Departments of Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg (Sweden)
- Department of Gynecologic Oncology, Karolinska University Hospital, Stockholm (Sweden)
Citation Formats
Waldenstroem, Ann-Charlotte, Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)], Olsson, Caroline, Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)], Wilderaeng, Ulrica, Dunberger, Gail, Lind, Helena, Al-Abany, Massoud, Department of Hospital Physics, Karolinska University Hospital, Stockholm (Sweden)], Palm, Asa, Avall-Lundqvist, Elisabeth, Johansson, Karl-Axel, Steineck, Gunnar, and Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)].
Pain and Mean Absorbed Dose to the Pubic Bone After Radiotherapy Among Gynecological Cancer Survivors.
United States: N. p.,
2011.
Web.
doi:10.1016/j.ijrobp.2010.04.007.
Waldenstroem, Ann-Charlotte, Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)], Olsson, Caroline, Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)], Wilderaeng, Ulrica, Dunberger, Gail, Lind, Helena, Al-Abany, Massoud, Department of Hospital Physics, Karolinska University Hospital, Stockholm (Sweden)], Palm, Asa, Avall-Lundqvist, Elisabeth, Johansson, Karl-Axel, Steineck, Gunnar, & Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)].
Pain and Mean Absorbed Dose to the Pubic Bone After Radiotherapy Among Gynecological Cancer Survivors.
United States.
https://doi.org/10.1016/j.ijrobp.2010.04.007
Waldenstroem, Ann-Charlotte, Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)], Olsson, Caroline, Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)], Wilderaeng, Ulrica, Dunberger, Gail, Lind, Helena, Al-Abany, Massoud, Department of Hospital Physics, Karolinska University Hospital, Stockholm (Sweden)], Palm, Asa, Avall-Lundqvist, Elisabeth, Johansson, Karl-Axel, Steineck, Gunnar, and Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)].
2011.
"Pain and Mean Absorbed Dose to the Pubic Bone After Radiotherapy Among Gynecological Cancer Survivors."
United States.
https://doi.org/10.1016/j.ijrobp.2010.04.007.
@misc{etde_21587593,
title = {Pain and Mean Absorbed Dose to the Pubic Bone After Radiotherapy Among Gynecological Cancer Survivors}
author = {Waldenstroem, Ann-Charlotte, Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)], Olsson, Caroline, Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)], Wilderaeng, Ulrica, Dunberger, Gail, Lind, Helena, Al-Abany, Massoud, Department of Hospital Physics, Karolinska University Hospital, Stockholm (Sweden)], Palm, Asa, Avall-Lundqvist, Elisabeth, Johansson, Karl-Axel, Steineck, Gunnar, and Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)]}
abstractNote = {Purpose: To analyze the relationship between mean absorbed dose to the pubic bone after pelvic radiotherapy for gynecological cancer and occurrence of pubic bone pain among long-term survivors. Methods and Materials: In an unselected, population-based study, we identified 823 long-term gynecological cancer survivors treated with pelvic radiotherapy during 1991-2003. For comparison, we used a non-radiation-treated control population of 478 matched women from the Swedish Population Register. Pain, intensity of pain, and functional impairment due to pain in the pubic bone were assessed with a study-specific postal questionnaire. Results: We analyzed data from 650 survivors (participation rate 79%) with median follow-up of 6.3 years (range, 2.3-15.0 years) along with 344 control women (participation rate, 72 %). Ten percent of the survivors were treated with radiotherapy; ninety percent with surgery plus radiotherapy. Brachytherapy was added in 81%. Complete treatment records were recovered for 538/650 survivors, with dose distribution data including dose-volume histograms over the pubic bone. Pubic bone pain was reported by 73 survivors (11%); 59/517 (11%) had been exposed to mean absorbed external beam doses <52.5 Gy to the pubic bone and 5/12 (42%) to mean absorbed external beam doses {>=}52.5 Gy. Thirty-three survivors reported pain affecting sleep, a 13-fold increased prevalence compared with control women. Forty-nine survivors reported functional impairment measured as pain walking indoors, a 10-fold increased prevalence. Conclusions: Mean absorbed external beam dose above 52.5 Gy to the pubic bone increases the occurrence of pain in the pubic bone and may affect daily life of long-term survivors treated with radiotherapy for gynecological cancer.}
doi = {10.1016/j.ijrobp.2010.04.007}
journal = []
issue = {4}
volume = {80}
place = {United States}
year = {2011}
month = {Jul}
}
title = {Pain and Mean Absorbed Dose to the Pubic Bone After Radiotherapy Among Gynecological Cancer Survivors}
author = {Waldenstroem, Ann-Charlotte, Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)], Olsson, Caroline, Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg (Sweden)], Wilderaeng, Ulrica, Dunberger, Gail, Lind, Helena, Al-Abany, Massoud, Department of Hospital Physics, Karolinska University Hospital, Stockholm (Sweden)], Palm, Asa, Avall-Lundqvist, Elisabeth, Johansson, Karl-Axel, Steineck, Gunnar, and Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm (Sweden)]}
abstractNote = {Purpose: To analyze the relationship between mean absorbed dose to the pubic bone after pelvic radiotherapy for gynecological cancer and occurrence of pubic bone pain among long-term survivors. Methods and Materials: In an unselected, population-based study, we identified 823 long-term gynecological cancer survivors treated with pelvic radiotherapy during 1991-2003. For comparison, we used a non-radiation-treated control population of 478 matched women from the Swedish Population Register. Pain, intensity of pain, and functional impairment due to pain in the pubic bone were assessed with a study-specific postal questionnaire. Results: We analyzed data from 650 survivors (participation rate 79%) with median follow-up of 6.3 years (range, 2.3-15.0 years) along with 344 control women (participation rate, 72 %). Ten percent of the survivors were treated with radiotherapy; ninety percent with surgery plus radiotherapy. Brachytherapy was added in 81%. Complete treatment records were recovered for 538/650 survivors, with dose distribution data including dose-volume histograms over the pubic bone. Pubic bone pain was reported by 73 survivors (11%); 59/517 (11%) had been exposed to mean absorbed external beam doses <52.5 Gy to the pubic bone and 5/12 (42%) to mean absorbed external beam doses {>=}52.5 Gy. Thirty-three survivors reported pain affecting sleep, a 13-fold increased prevalence compared with control women. Forty-nine survivors reported functional impairment measured as pain walking indoors, a 10-fold increased prevalence. Conclusions: Mean absorbed external beam dose above 52.5 Gy to the pubic bone increases the occurrence of pain in the pubic bone and may affect daily life of long-term survivors treated with radiotherapy for gynecological cancer.}
doi = {10.1016/j.ijrobp.2010.04.007}
journal = []
issue = {4}
volume = {80}
place = {United States}
year = {2011}
month = {Jul}
}