You need JavaScript to view this
ETDEWEB   /       /    Prognostic impact of postoperative, pre-irradiation {sup 18}F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy

Prognostic impact of postoperative, pre-irradiation {sup 18}F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy

Journal Article:

SAVE / SHARE

XML RIS EndNote CSV/Excel JSON

Abstract

Background and purpose: Resection is considered as essential for the efficacy of modern adjuvant treatment of glioblastoma multiforme (GBM). Previous studies have indicated that amino acid PET is more specific than contrast enhancement on MRI for detecting residual tumor tissue after surgery. In a prospective study we investigated the prognostic impact of postoperative tumor volume and tumor/brain ratios (TBR) in PET using O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine (FET) in comparison with MRI. Materials and methods: Forty-four patients with GBM were investigated by FET PET and MRI after surgery. Tumor volume in FET PET with a tumor/brain ratio (TBR) > 1.6 and a TBR > 2, mean and maximum TBR and gadolinium contrast-enhancement on MRI (Gd-volume) were determined. Thereafter patients received a fractionated radiotherapy with concomitant temozolomide (RCX). The median follow-up was 15.4 (3-35) months. The prognostic value of postoperative residual tumor volume in FET PET, TBR{sub mean,} TBR{sub max} and Gd-volume was evaluated using Kaplan-Maier estimates for disease-free survival (DFS) and overall survival (OS). Results: Postoperative tumor volume in FET PET had a significant independent influence on OS and DFS (OS 20.0 vs. 6.9 months; DFS 9.6 vs. 5.1 months, p < 0.001; cut-off 25 ml). Similar results were observed when a TBR  More>>
Authors:
Piroth, Marc D., E-mail: mpiroth@ukaachen.de [Department of Radiation Oncology, RWTH Aachen University Hospital (Germany); Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]; Holy, Richard; Pinkawa, Michael; [1]  Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]; Stoffels, Gabriele; [2]  Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]; Kaiser, Hans J; [3]  Galldiks, Norbert; [2]  Department of Neurology, University Hospital Cologne (Germany)]; Herzog, Hans; [2]  Coenen, Heinz H; [2]  Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]; Eble, Michael J; [1]  Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]; Langen, Karl J; [2]  Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]
  1. Department of Radiation Oncology, RWTH Aachen University Hospital (Germany)
  2. Institute of Neuroscience and Medicine, Forschungszentrum Juelich (Germany)
  3. Department of Nuclear Medicine, RWTH Aachen University Hospital (Germany)
Publication Date:
May 15, 2011
DOI:
https://doi.org/10.1016/j.radonc.2011.03.006
Product Type:
Journal Article
Resource Relation:
Journal Name: Radiotherapy and Oncology; Journal Volume: 99; Journal Issue: 2; Other Information: DOI: 10.1016/j.radonc.2011.03.006; PII: S0167-8140(11)00127-7; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; COMPARATIVE EVALUATIONS; FLUORINE 18; GADOLINIUM; GLIOMAS; IRRADIATION; NMR IMAGING; PATIENTS; RADIOTHERAPY; SURGERY; TYROSINE; UPTAKE; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; EVALUATION; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEDICINE; METALS; NANOSECONDS LIVING RADIOISOTOPES; NEOPLASMS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RADIOLOGY; RARE EARTHS; THERAPY
OSTI ID:
21586470
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0167-8140; RAONDT; TRN: IE12R0097064851
Availability:
Available from http://dx.doi.org/10.1016/j.radonc.2011.03.006
Submitting Site:
INIS
Size:
page(s) 218-224
Announcement Date:
Aug 27, 2012

Journal Article:

SAVE / SHARE

XML RIS EndNote CSV/Excel JSON

Citation Formats

Piroth, Marc D., E-mail: mpiroth@ukaachen.de [Department of Radiation Oncology, RWTH Aachen University Hospital (Germany), Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Holy, Richard, Pinkawa, Michael, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Stoffels, Gabriele, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Kaiser, Hans J, Galldiks, Norbert, Department of Neurology, University Hospital Cologne (Germany)], Herzog, Hans, Coenen, Heinz H, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Eble, Michael J, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Langen, Karl J, and Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]. Prognostic impact of postoperative, pre-irradiation {sup 18}F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy. Ireland: N. p., 2011. Web. doi:10.1016/j.radonc.2011.03.006.
Piroth, Marc D., E-mail: mpiroth@ukaachen.de [Department of Radiation Oncology, RWTH Aachen University Hospital (Germany), Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Holy, Richard, Pinkawa, Michael, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Stoffels, Gabriele, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Kaiser, Hans J, Galldiks, Norbert, Department of Neurology, University Hospital Cologne (Germany)], Herzog, Hans, Coenen, Heinz H, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Eble, Michael J, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Langen, Karl J, &amp; Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]. Prognostic impact of postoperative, pre-irradiation {sup 18}F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy. Ireland. https://doi.org/10.1016/j.radonc.2011.03.006
Piroth, Marc D., E-mail: mpiroth@ukaachen.de [Department of Radiation Oncology, RWTH Aachen University Hospital (Germany), Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Holy, Richard, Pinkawa, Michael, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Stoffels, Gabriele, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Kaiser, Hans J, Galldiks, Norbert, Department of Neurology, University Hospital Cologne (Germany)], Herzog, Hans, Coenen, Heinz H, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Eble, Michael J, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Langen, Karl J, and Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]. 2011. "Prognostic impact of postoperative, pre-irradiation {sup 18}F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy." Ireland. https://doi.org/10.1016/j.radonc.2011.03.006.
@misc{etde_21586470,
title = {Prognostic impact of postoperative, pre-irradiation {sup 18}F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy}
 author = {Piroth, Marc D., E-mail: mpiroth@ukaachen.de [Department of Radiation Oncology, RWTH Aachen University Hospital (Germany), Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Holy, Richard, Pinkawa, Michael, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Stoffels, Gabriele, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Kaiser, Hans J, Galldiks, Norbert, Department of Neurology, University Hospital Cologne (Germany)], Herzog, Hans, Coenen, Heinz H, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Eble, Michael J, Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)], Langen, Karl J, and Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Forschungszentrum Juelich (Germany)]}
 abstractNote = {Background and purpose: Resection is considered as essential for the efficacy of modern adjuvant treatment of glioblastoma multiforme (GBM). Previous studies have indicated that amino acid PET is more specific than contrast enhancement on MRI for detecting residual tumor tissue after surgery. In a prospective study we investigated the prognostic impact of postoperative tumor volume and tumor/brain ratios (TBR) in PET using O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine (FET) in comparison with MRI. Materials and methods: Forty-four patients with GBM were investigated by FET PET and MRI after surgery. Tumor volume in FET PET with a tumor/brain ratio (TBR) > 1.6 and a TBR > 2, mean and maximum TBR and gadolinium contrast-enhancement on MRI (Gd-volume) were determined. Thereafter patients received a fractionated radiotherapy with concomitant temozolomide (RCX). The median follow-up was 15.4 (3-35) months. The prognostic value of postoperative residual tumor volume in FET PET, TBR{sub mean,} TBR{sub max} and Gd-volume was evaluated using Kaplan-Maier estimates for disease-free survival (DFS) and overall survival (OS). Results: Postoperative tumor volume in FET PET had a significant independent influence on OS and DFS (OS 20.0 vs. 6.9 months; DFS 9.6 vs. 5.1 months, p < 0.001; cut-off 25 ml). Similar results were observed when a TBR {>=} 2 (cut-off 10 ml) was used to define the tumor volume in {sup 18}F-FET PET. The TBR{sub mean} and TBR{sub max} of FET uptake had a significant influence on DFS (p < 0.05). Gd-volume in MRI had significant effect on OS and DFS in the univariate analysis. No independent significant influence in OS or DFS could be observed for Gd-volume in MRI. Conclusions: Our data indicate that the tumor volume in FET PET after surgery of GBM has a strong prognostic impact for these patients. FET PET appears to be helpful to determine the residual tumor volume after surgery of GBM and may serve as a valuable tool for optimal planning of radiation treatment.}
 doi = {10.1016/j.radonc.2011.03.006}
 journal = []
 issue = {2}
 volume = {99}
 place = {Ireland}
 year = {2011}
 month = {May}
 }