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Determinants of LSIL Regression in Women from a Colombian Cohort; Determinantes de la regresion de lesiones cervicales de bajo grado en una cohorte de mujeres colombianas.

Journal Article:

Abstract

Objective: To analyze the role of Human Papillomavirus (HPV) and other risk factors in the regression of cervical lesions in women from the Bogota Cohort. Methods: 200 HPV positive women with abnormal cytology were included for regression analysis. The time of lesion regression was modeled using methods for interval censored survival time data. Median duration of total follow-up was 9 years. Results: 80 (40%) women were diagnosed with Atypical Squamous Cells of Undetermined Significance (ASCUS) or Atypical Glandular Cells of Undetermined Significance (AGUS) while 120 (60%) were diagnosed with Low Grade Squamous Intra-epithelial Lesions (LSIL). Globally, 40% of the lesions were still present at first year of follow up, while 1.5% was still present at 5 year check-up. The multivariate model showed similar regression rates for lesions in women with ASCUS/AGUS and women with LSIL (HR= 0.82, 95% CI 0.59-1.12). Women infected with HR HPV types and those with mixed infections had lower regression rates for lesions than did women infected with LR types (HR=0.526, 95% CI 0.33-0.84, for HR types and HR=0.378, 95% CI 0.20-0.69, for mixed infections). Furthermore, women over 30 years had a higher lesion regression rate than did women under 30 years (HR1.53, 95% CI 1.03-2.27).  More>>
Publication Date:
Jul 01, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Revista Colombiana de Cancerologia; Journal Volume: 14; Journal Issue: 4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; COLOMBIA; CYTOLOGY; DISEASES; FEMALE GENITALS; FEMALES; GYNECOLOGY; IMAGE PROCESSING; IMAGES; INFECTIOUS DISEASES; UROGENITAL SYSTEM DISEASES; WOMEN; ANIMALS; BIOLOGY; BODY; DEVELOPING COUNTRIES; LATIN AMERICA; MAMMALS; MAN; MEDICINE; NEOPLASMS; ORGANS; PRIMATES; PROCESSING; SOUTH AMERICA; VERTEBRATES
OSTI ID:
21575303
Country of Origin:
Colombia
Language:
Spanish
Other Identifying Numbers:
Journal ID: ISSN 0123-9015; TRN: CO1200032053029
Submitting Site:
INIS
Size:
page(s) 199-209
Announcement Date:
Jul 26, 2012

Journal Article:

Citation Formats

Molano, Monica, Gonzalez, Mauricio, Gamboa, Oscar, Ortiz, Natasha, Luna, Joaquin, Hernandez, Gustavo, Posso, Hector, Murillo, Raul, and Munoz, Nubia. Determinants of LSIL Regression in Women from a Colombian Cohort; Determinantes de la regresion de lesiones cervicales de bajo grado en una cohorte de mujeres colombianas.. Colombia: N. p., 2010. Web.
Molano, Monica, Gonzalez, Mauricio, Gamboa, Oscar, Ortiz, Natasha, Luna, Joaquin, Hernandez, Gustavo, Posso, Hector, Murillo, Raul, & Munoz, Nubia. Determinants of LSIL Regression in Women from a Colombian Cohort; Determinantes de la regresion de lesiones cervicales de bajo grado en una cohorte de mujeres colombianas.. Colombia.
Molano, Monica, Gonzalez, Mauricio, Gamboa, Oscar, Ortiz, Natasha, Luna, Joaquin, Hernandez, Gustavo, Posso, Hector, Murillo, Raul, and Munoz, Nubia. 2010. "Determinants of LSIL Regression in Women from a Colombian Cohort; Determinantes de la regresion de lesiones cervicales de bajo grado en una cohorte de mujeres colombianas." Colombia.
@misc{etde_21575303,
title = {Determinants of LSIL Regression in Women from a Colombian Cohort; Determinantes de la regresion de lesiones cervicales de bajo grado en una cohorte de mujeres colombianas.}
author = {Molano, Monica, Gonzalez, Mauricio, Gamboa, Oscar, Ortiz, Natasha, Luna, Joaquin, Hernandez, Gustavo, Posso, Hector, Murillo, Raul, and Munoz, Nubia}
abstractNote = {Objective: To analyze the role of Human Papillomavirus (HPV) and other risk factors in the regression of cervical lesions in women from the Bogota Cohort. Methods: 200 HPV positive women with abnormal cytology were included for regression analysis. The time of lesion regression was modeled using methods for interval censored survival time data. Median duration of total follow-up was 9 years. Results: 80 (40%) women were diagnosed with Atypical Squamous Cells of Undetermined Significance (ASCUS) or Atypical Glandular Cells of Undetermined Significance (AGUS) while 120 (60%) were diagnosed with Low Grade Squamous Intra-epithelial Lesions (LSIL). Globally, 40% of the lesions were still present at first year of follow up, while 1.5% was still present at 5 year check-up. The multivariate model showed similar regression rates for lesions in women with ASCUS/AGUS and women with LSIL (HR= 0.82, 95% CI 0.59-1.12). Women infected with HR HPV types and those with mixed infections had lower regression rates for lesions than did women infected with LR types (HR=0.526, 95% CI 0.33-0.84, for HR types and HR=0.378, 95% CI 0.20-0.69, for mixed infections). Furthermore, women over 30 years had a higher lesion regression rate than did women under 30 years (HR1.53, 95% CI 1.03-2.27). The study showed that the median time for lesion regression was 9 months while the median time for HPV clearance was 12 months. Conclusions: In the studied population, the type of infection and the age of the women are critical factors for the regression of cervical lesions.}
journal = {Revista Colombiana de Cancerologia}
issue = {4}
volume = {14}
place = {Colombia}
year = {2010}
month = {Jul}
}