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Stem cell, cytokine and plastic surgical management for radiation injuries

Abstract

Increasing concern on systemic and local radiation injuries caused by nuclear power plant accident, therapeutic irradiation or nuclear terrorism should be treated and prevented properly for life-saving and improved wound management. We therefore reviewed our therapeutic regimens and for local radiation injuries and propose surgical methods reflecting the importance of the systemic and general conditions. For local radiation injuries, after careful and complete debridement, sequential surgeries with local flap, arterialized or perforator flap and to free flap are used when the patients' general conditions allow. Occasionally, undetermined wound margins in acute emergency radiation injuries and the regenerative surgical modalities should be attempted with temporal artificial dermis impregnated and sprayed with angiogenic factor such as basic fibroblast growth factor (bFGF) and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Human mesenchymal stem cells (hMSCs) and adipose-derived stem cells (ADSCs), together with angiogenic and mitogenic factor of basic fibroblast growth factor (bFGF) and an artificial dermis were applied over the excised irradiated skin defect are tested for differentiation and local stimulation effects in the radiation-exposed wounds. The perforator flap and artificial dermal template with growth factor were successful for reconstruction in patients who are suffering from complex  More>>
Authors:
Akita, Sadanori; Hirano, Akiyoshi; [1]  Akino, Kozo; [2]  Ohtsuru, Akira; [3]  Yamashita, Shunichi; [4]  World Health Organization (WHO), Nagasaki (Japan)]
  1. Dept. of Plastic and Reconstructive Surgery, Nagasaki (Japan)
  2. Nagasaki Univ. (Japan). Graduate School of Biomedical Sciences, Dept. of Neuroanatomy
  3. Nagasaki Univ. Hospital (Japan). Takashi Nagai Memorial, International Hibakusha Medical Center
  4. Nagasaki Univ. School of Medicine (Japan). Atomic Bomb Disease Institute
Publication Date:
Jul 01, 2008
Product Type:
Conference
Report Number:
INIS-AR-C-1586
Resource Relation:
Conference: IRPA 12: 12. International congress of the International Radiation Protection Association (IRPA): Strengthening radiation protection worldwide, Buenos Aires (Argentina), 19-24 Oct 2008; Other Information: Oral presentation; 10 refs., 5 figs.
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; ACCIDENTS; DEFECTS; DISEASE INCIDENCE; FIBROBLASTS; GROWTH FACTORS; HEALING; HUMAN POPULATIONS; IN VITRO; INFLAMMATION; IRRADIATION; MANAGEMENT; NUCLEAR POWER PLANTS; PATIENTS; PLASTICS; RADIATION INJURIES; SKIN; STEM CELLS; SURGERY; WOUNDS; ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BODY; CONNECTIVE TISSUE CELLS; DISEASES; INJURIES; MATERIALS; MEDICINE; MITOGENS; NUCLEAR FACILITIES; ORGANIC COMPOUNDS; ORGANIC POLYMERS; ORGANS; PATHOLOGICAL CHANGES; PETROCHEMICALS; PETROLEUM PRODUCTS; POLYMERS; POPULATIONS; POWER PLANTS; PROTEINS; RADIATION EFFECTS; SOMATIC CELLS; SYMPTOMS; SYNTHETIC MATERIALS; THERMAL POWER PLANTS
OSTI ID:
21575021
Research Organizations:
International Radiation Protection Association (IRPA), Fontenay-aux-Roses (France); Sociedad Argentina de Radioproteccion (SAR), Buenos Aires (Argentina); International Atomic Energy Agency (IAEA), Vienna (Austria); Pan American Health Organization (PAHO), Washington, DC (United States); World Health Organization (WHO), Geneva (Switzerland)
Country of Origin:
Argentina
Language:
English
Other Identifying Numbers:
TRN: AR12C0136052725
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
10 pages
Announcement Date:
Jul 26, 2012

Citation Formats

Akita, Sadanori, Hirano, Akiyoshi, Akino, Kozo, Ohtsuru, Akira, Yamashita, Shunichi, and World Health Organization (WHO), Nagasaki (Japan)]. Stem cell, cytokine and plastic surgical management for radiation injuries. Argentina: N. p., 2008. Web.
Akita, Sadanori, Hirano, Akiyoshi, Akino, Kozo, Ohtsuru, Akira, Yamashita, Shunichi, & World Health Organization (WHO), Nagasaki (Japan)]. Stem cell, cytokine and plastic surgical management for radiation injuries. Argentina.
Akita, Sadanori, Hirano, Akiyoshi, Akino, Kozo, Ohtsuru, Akira, Yamashita, Shunichi, and World Health Organization (WHO), Nagasaki (Japan)]. 2008. "Stem cell, cytokine and plastic surgical management for radiation injuries." Argentina.
@misc{etde_21575021,
title = {Stem cell, cytokine and plastic surgical management for radiation injuries}
author = {Akita, Sadanori, Hirano, Akiyoshi, Akino, Kozo, Ohtsuru, Akira, Yamashita, Shunichi, and World Health Organization (WHO), Nagasaki (Japan)]}
abstractNote = {Increasing concern on systemic and local radiation injuries caused by nuclear power plant accident, therapeutic irradiation or nuclear terrorism should be treated and prevented properly for life-saving and improved wound management. We therefore reviewed our therapeutic regimens and for local radiation injuries and propose surgical methods reflecting the importance of the systemic and general conditions. For local radiation injuries, after careful and complete debridement, sequential surgeries with local flap, arterialized or perforator flap and to free flap are used when the patients' general conditions allow. Occasionally, undetermined wound margins in acute emergency radiation injuries and the regenerative surgical modalities should be attempted with temporal artificial dermis impregnated and sprayed with angiogenic factor such as basic fibroblast growth factor (bFGF) and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Human mesenchymal stem cells (hMSCs) and adipose-derived stem cells (ADSCs), together with angiogenic and mitogenic factor of basic fibroblast growth factor (bFGF) and an artificial dermis were applied over the excised irradiated skin defect are tested for differentiation and local stimulation effects in the radiation-exposed wounds. The perforator flap and artificial dermal template with growth factor were successful for reconstruction in patients who are suffering from complex underlying disease. Patients were uneventfully treated with minimal morbidities. The hMSCs are strongly proliferative even after 20 Gy irradiation in vitro. Immediate artificial dermis application impregnated with hMSCs and bFGF over the 20 Gy irradiated skin and soft tissues demonstrated the significantly improved fat angio genesis, architected dermal reconstitution and less inflammatory epidermal recovery. Even though emergent cases are more often experienced, detailed understanding of underlying diseases and rational reconstructive procedures brings about good outcomes for difficult irradiated wound healing. Also, ADSCs are also implicated in the limited local injuries for short cell harvesting and processing time in the same subject. (author)}
place = {Argentina}
year = {2008}
month = {Jul}
}