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A review of novel strategies of sample preparation for the determination of antibacterial residues in foodstuffs using liquid chromatography-based analytical methods

Abstract

The determination of trace residues and contaminants in food has been of growing concern over the past few years. Residual antibacterials in food constitute a risk to human health, especially because they can contribute to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. Therefore, to ensure food safety EU and USA regulatory agencies have established lists of forbidden or banned substances and tolerance levels for authorized veterinary drugs (e.g. antibacterials). In addition, the EU Commission Decision 2002/657/EC has set requirements about the performance of analytical methods for the determination of veterinary drug residues in food and feedstuffs. During the past years, the use of powerful mass spectrometric detectors in combination with innovative chromatographic technologies has solved many problems related to sensitivity and selectivity of this type of analysis. However sample preparation still remains as the bottleneck step, mainly in terms of analysis time and sources of error. This review covering research published between 2004 and 2008 intends to provide an update overview of the past five years, on recent trends in sample preparation for the determination of antibacterial residues in foods, making special emphasis in on-line, high-throughput, multi-class methods and including several applications in detail.
Authors:
Marazuela, M.D., E-mail: marazuela@quim.ucm.es; [1]  Bogialli, S [2] 
  1. Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, E-28040 Madrid (Spain)
  2. Department of Chemistry, University of Rome 'La Sapienza', Piazza Aldo Moro, 5 00185 Rome (Italy)
Publication Date:
Jul 10, 2009
Product Type:
Journal Article
Resource Relation:
Journal Name: Analytica Chimica Acta; Journal Volume: 645; Journal Issue: 1-2; Other Information: DOI: 10.1016/j.aca.2009.04.031; PII: S0003-2670(09)00571-6; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; AMP; BACTERIA; CHLORAMPHENICOL; ERRORS; ERYTHROMYCIN; FOOD; FOOD CHAINS; HAZARDS; LACTAMS; LIQUID COLUMN CHROMATOGRAPHY; MASS SPECTROSCOPY; NEOMYCIN; NITRIC OXIDE; OXYTETRACYCLINE; PENICILLIN; PUBLIC HEALTH; RESIDUES; SAMPLE PREPARATION; SENSITIVITY; STREPTOMYCIN; AMIDES; ANTIBIOTICS; ANTI-INFECTIVE AGENTS; CHALCOGENIDES; CHROMATOGRAPHY; DRUGS; MICROORGANISMS; NITROGEN COMPOUNDS; NITROGEN OXIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; SEPARATION PROCESSES; SPECTROSCOPY; TETRACYCLINES
OSTI ID:
21556969
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0003-2670; ACACAM; TRN: NL09R7455034787
Availability:
Available from http://dx.doi.org/10.1016/j.aca.2009.04.031
Submitting Site:
NLN
Size:
page(s) 5-17
Announcement Date:
May 31, 2012

Citation Formats

Marazuela, M.D., E-mail: marazuela@quim.ucm.es, and Bogialli, S. A review of novel strategies of sample preparation for the determination of antibacterial residues in foodstuffs using liquid chromatography-based analytical methods. Netherlands: N. p., 2009. Web. doi:10.1016/j.aca.2009.04.031.
Marazuela, M.D., E-mail: marazuela@quim.ucm.es, & Bogialli, S. A review of novel strategies of sample preparation for the determination of antibacterial residues in foodstuffs using liquid chromatography-based analytical methods. Netherlands. doi:10.1016/j.aca.2009.04.031.
Marazuela, M.D., E-mail: marazuela@quim.ucm.es, and Bogialli, S. 2009. "A review of novel strategies of sample preparation for the determination of antibacterial residues in foodstuffs using liquid chromatography-based analytical methods." Netherlands. doi:10.1016/j.aca.2009.04.031. https://www.osti.gov/servlets/purl/10.1016/j.aca.2009.04.031.
@misc{etde_21556969,
title = {A review of novel strategies of sample preparation for the determination of antibacterial residues in foodstuffs using liquid chromatography-based analytical methods}
author = {Marazuela, M.D., E-mail: marazuela@quim.ucm.es, and Bogialli, S}
abstractNote = {The determination of trace residues and contaminants in food has been of growing concern over the past few years. Residual antibacterials in food constitute a risk to human health, especially because they can contribute to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. Therefore, to ensure food safety EU and USA regulatory agencies have established lists of forbidden or banned substances and tolerance levels for authorized veterinary drugs (e.g. antibacterials). In addition, the EU Commission Decision 2002/657/EC has set requirements about the performance of analytical methods for the determination of veterinary drug residues in food and feedstuffs. During the past years, the use of powerful mass spectrometric detectors in combination with innovative chromatographic technologies has solved many problems related to sensitivity and selectivity of this type of analysis. However sample preparation still remains as the bottleneck step, mainly in terms of analysis time and sources of error. This review covering research published between 2004 and 2008 intends to provide an update overview of the past five years, on recent trends in sample preparation for the determination of antibacterial residues in foods, making special emphasis in on-line, high-throughput, multi-class methods and including several applications in detail.}
doi = {10.1016/j.aca.2009.04.031}
journal = {Analytica Chimica Acta}
issue = {1-2}
volume = {645}
place = {Netherlands}
year = {2009}
month = {Jul}
}