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Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity

Abstract

The immunological responses induced by oxidized water-soluble multi-walled carbon nanotubes on a hepatocarcinoma tumor-bearing mice model via a local administration of subcutaneous injection were investigated. Experimental results show that the subcutaneously injected carbon nanotubes induced significant activation of the complement system, promoted inflammatory cytokines' production and stimulated macrophages' phagocytosis and activation. All of these responses increased the general activity of the host immune system and inhibited the progression of tumor growth.
Authors:
Jie, Meng; Man, Yang; Fumin, Jia; Hua, Kong; Weiqi, Zhang; Haiyan, Xu; [1]  Chaoying, Wang; Sishen, Xie; [2]  Xing Jianmin, E-mail: xuhy@pumc.edu.cn [3] 
  1. Department of Biomedical Engineering, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005 (China)
  2. Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, 8 Nan San Jie, Zhongguancun, Beijing100080 (China)
  3. Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029 (China)
Publication Date:
Apr 09, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Nanotechnology (Print); Journal Volume: 21; Journal Issue: 14; Other Information: DOI: 10.1088/0957-4484/21/14/145104; PII: S0957-4484(10)35975-7
Subject:
60 APPLIED LIFE SCIENCES; 77 NANOSCIENCE AND NANOTECHNOLOGY; BEARINGS; CARBON; COMPLEMENT; GROWTH; HOST; INFLAMMATION; LYMPHOKINES; MACROPHAGES; MICE; NANOTUBES; NEOPLASMS; PHAGOCYTOSIS; SUBCUTANEOUS INJECTION; ANIMAL CELLS; ANIMALS; CONNECTIVE TISSUE CELLS; DISEASES; ELEMENTS; GROWTH FACTORS; INJECTION; INTAKE; MAMMALS; MITOGENS; NANOSTRUCTURES; NONMETALS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PHAGOCYTES; PROTEINS; RODENTS; SOMATIC CELLS; SYMPTOMS; VERTEBRATES
OSTI ID:
21542924
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0957-4484; TRN: GB10O1126022016
Availability:
Available from http://dx.doi.org/10.1088/0957-4484/21/14/145104
Submitting Site:
GBN
Size:
9 pages
Announcement Date:
Apr 16, 2012

Citation Formats

Jie, Meng, Man, Yang, Fumin, Jia, Hua, Kong, Weiqi, Zhang, Haiyan, Xu, Chaoying, Wang, Sishen, Xie, and Xing Jianmin, E-mail: xuhy@pumc.edu.cn. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. United Kingdom: N. p., 2010. Web. doi:10.1088/0957-4484/21/14/145104.
Jie, Meng, Man, Yang, Fumin, Jia, Hua, Kong, Weiqi, Zhang, Haiyan, Xu, Chaoying, Wang, Sishen, Xie, & Xing Jianmin, E-mail: xuhy@pumc.edu.cn. Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity. United Kingdom. doi:10.1088/0957-4484/21/14/145104.
Jie, Meng, Man, Yang, Fumin, Jia, Hua, Kong, Weiqi, Zhang, Haiyan, Xu, Chaoying, Wang, Sishen, Xie, and Xing Jianmin, E-mail: xuhy@pumc.edu.cn. 2010. "Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity." United Kingdom. doi:10.1088/0957-4484/21/14/145104. https://www.osti.gov/servlets/purl/10.1088/0957-4484/21/14/145104.
@misc{etde_21542924,
title = {Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity}
author = {Jie, Meng, Man, Yang, Fumin, Jia, Hua, Kong, Weiqi, Zhang, Haiyan, Xu, Chaoying, Wang, Sishen, Xie, and Xing Jianmin, E-mail: xuhy@pumc.edu.cn}
abstractNote = {The immunological responses induced by oxidized water-soluble multi-walled carbon nanotubes on a hepatocarcinoma tumor-bearing mice model via a local administration of subcutaneous injection were investigated. Experimental results show that the subcutaneously injected carbon nanotubes induced significant activation of the complement system, promoted inflammatory cytokines' production and stimulated macrophages' phagocytosis and activation. All of these responses increased the general activity of the host immune system and inhibited the progression of tumor growth.}
doi = {10.1088/0957-4484/21/14/145104}
journal = {Nanotechnology (Print)}
issue = {14}
volume = {21}
place = {United Kingdom}
year = {2010}
month = {Apr}
}