Abstract
The influence of androgen deprivation therapy (ADT) on {sup 11}C-choline uptake in patients with prostate cancer (PC) has not yet been clarified. The aim of our study was to investigate this issue by means of sequential {sup 11}C-choline positron emission tomography (PET)/CT in patients with recurrent PC. We retrospectively studied 14 recurrent PC patients (mean age 67 years, range 55-82) during follow-up after radical prostatectomy (RP) with rising serum prostate-specific antigen (PSA) levels. All patients had undergone at least two consecutive {sup 11}C-choline PET/CT scans: the first {sup 11}C-choline PET/CT before commencing ADT and the second {sup 11}C-choline PET/CT after 6 months of ADT administration. The mean serum PSA level before ADT was 17.0 {+-} 44.1 ng/ml. After 6 months of ADT administration the PSA value significantly decreased in comparison to baseline (PSA = 2.4 {+-} 3.1 ng/ml, p <.025). Moreover, before starting ADT, 13 of 14 patients had positive {sup 11}C-choline PET/CT for metastatic spread, while after 6 months of ADT administration in 9 of 14 patients {sup 11}C-choline PET/CT became negative. These preliminary results suggest that ADT significantly reduces {sup 11}C-choline uptake in androgen-sensitive PC patients. (orig.)
Fuccio, Chiara;
Castellucci, Paolo;
Celli, Monica;
Malizia, Claudio;
Pettinato, Vincenzina;
Fanti, Stefano;
[1]
Schiavina, Riccardo;
Martorana, Giuseppe;
[2]
Rubello, Domenico;
[3]
S. Maria della Misericordia Hospital, Department of Nuclear Medicine, Radiology, Medical Physics, Service of Nuclear Medicine, PET/CT Centre, Rovigo (Italy)];
Profitos, Marta Barios;
[4]
Marzola, Maria Cristina
[3]
- University of Bologna, Department of Nuclear Medicine, PAD. 30, Sant'Orsola-Malpighi Hospital, Bologna (Italy)
- University of Bologna, Department of Urology, Sant'Orsola-Malpighi Hospital, Bologna (Italy)
- Santa Maria della Misericordia Hospital, Department of Nuclear Medicine, Rovigo (Italy)
- Servei Medicina Nuclear Hospital, Vall D'Hebron, Barcelona (Spain)
Citation Formats
Fuccio, Chiara, Castellucci, Paolo, Celli, Monica, Malizia, Claudio, Pettinato, Vincenzina, Fanti, Stefano, Schiavina, Riccardo, Martorana, Giuseppe, Rubello, Domenico, S. Maria della Misericordia Hospital, Department of Nuclear Medicine, Radiology, Medical Physics, Service of Nuclear Medicine, PET/CT Centre, Rovigo (Italy)], Profitos, Marta Barios, and Marzola, Maria Cristina.
Androgen deprivation therapy influences the uptake of {sup 11}C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study.
Germany: N. p.,
2011.
Web.
doi:10.1007/S00259-011-1867-0.
Fuccio, Chiara, Castellucci, Paolo, Celli, Monica, Malizia, Claudio, Pettinato, Vincenzina, Fanti, Stefano, Schiavina, Riccardo, Martorana, Giuseppe, Rubello, Domenico, S. Maria della Misericordia Hospital, Department of Nuclear Medicine, Radiology, Medical Physics, Service of Nuclear Medicine, PET/CT Centre, Rovigo (Italy)], Profitos, Marta Barios, & Marzola, Maria Cristina.
Androgen deprivation therapy influences the uptake of {sup 11}C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study.
Germany.
https://doi.org/10.1007/S00259-011-1867-0
Fuccio, Chiara, Castellucci, Paolo, Celli, Monica, Malizia, Claudio, Pettinato, Vincenzina, Fanti, Stefano, Schiavina, Riccardo, Martorana, Giuseppe, Rubello, Domenico, S. Maria della Misericordia Hospital, Department of Nuclear Medicine, Radiology, Medical Physics, Service of Nuclear Medicine, PET/CT Centre, Rovigo (Italy)], Profitos, Marta Barios, and Marzola, Maria Cristina.
2011.
"Androgen deprivation therapy influences the uptake of {sup 11}C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study."
Germany.
https://doi.org/10.1007/S00259-011-1867-0.
@misc{etde_21533124,
title = {Androgen deprivation therapy influences the uptake of {sup 11}C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study}
author = {Fuccio, Chiara, Castellucci, Paolo, Celli, Monica, Malizia, Claudio, Pettinato, Vincenzina, Fanti, Stefano, Schiavina, Riccardo, Martorana, Giuseppe, Rubello, Domenico, S. Maria della Misericordia Hospital, Department of Nuclear Medicine, Radiology, Medical Physics, Service of Nuclear Medicine, PET/CT Centre, Rovigo (Italy)], Profitos, Marta Barios, and Marzola, Maria Cristina}
abstractNote = {The influence of androgen deprivation therapy (ADT) on {sup 11}C-choline uptake in patients with prostate cancer (PC) has not yet been clarified. The aim of our study was to investigate this issue by means of sequential {sup 11}C-choline positron emission tomography (PET)/CT in patients with recurrent PC. We retrospectively studied 14 recurrent PC patients (mean age 67 years, range 55-82) during follow-up after radical prostatectomy (RP) with rising serum prostate-specific antigen (PSA) levels. All patients had undergone at least two consecutive {sup 11}C-choline PET/CT scans: the first {sup 11}C-choline PET/CT before commencing ADT and the second {sup 11}C-choline PET/CT after 6 months of ADT administration. The mean serum PSA level before ADT was 17.0 {+-} 44.1 ng/ml. After 6 months of ADT administration the PSA value significantly decreased in comparison to baseline (PSA = 2.4 {+-} 3.1 ng/ml, p <.025). Moreover, before starting ADT, 13 of 14 patients had positive {sup 11}C-choline PET/CT for metastatic spread, while after 6 months of ADT administration in 9 of 14 patients {sup 11}C-choline PET/CT became negative. These preliminary results suggest that ADT significantly reduces {sup 11}C-choline uptake in androgen-sensitive PC patients. (orig.)}
doi = {10.1007/S00259-011-1867-0}
journal = []
issue = {11}
volume = {38}
place = {Germany}
year = {2011}
month = {Nov}
}
title = {Androgen deprivation therapy influences the uptake of {sup 11}C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study}
author = {Fuccio, Chiara, Castellucci, Paolo, Celli, Monica, Malizia, Claudio, Pettinato, Vincenzina, Fanti, Stefano, Schiavina, Riccardo, Martorana, Giuseppe, Rubello, Domenico, S. Maria della Misericordia Hospital, Department of Nuclear Medicine, Radiology, Medical Physics, Service of Nuclear Medicine, PET/CT Centre, Rovigo (Italy)], Profitos, Marta Barios, and Marzola, Maria Cristina}
abstractNote = {The influence of androgen deprivation therapy (ADT) on {sup 11}C-choline uptake in patients with prostate cancer (PC) has not yet been clarified. The aim of our study was to investigate this issue by means of sequential {sup 11}C-choline positron emission tomography (PET)/CT in patients with recurrent PC. We retrospectively studied 14 recurrent PC patients (mean age 67 years, range 55-82) during follow-up after radical prostatectomy (RP) with rising serum prostate-specific antigen (PSA) levels. All patients had undergone at least two consecutive {sup 11}C-choline PET/CT scans: the first {sup 11}C-choline PET/CT before commencing ADT and the second {sup 11}C-choline PET/CT after 6 months of ADT administration. The mean serum PSA level before ADT was 17.0 {+-} 44.1 ng/ml. After 6 months of ADT administration the PSA value significantly decreased in comparison to baseline (PSA = 2.4 {+-} 3.1 ng/ml, p <.025). Moreover, before starting ADT, 13 of 14 patients had positive {sup 11}C-choline PET/CT for metastatic spread, while after 6 months of ADT administration in 9 of 14 patients {sup 11}C-choline PET/CT became negative. These preliminary results suggest that ADT significantly reduces {sup 11}C-choline uptake in androgen-sensitive PC patients. (orig.)}
doi = {10.1007/S00259-011-1867-0}
journal = []
issue = {11}
volume = {38}
place = {Germany}
year = {2011}
month = {Nov}
}