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{sup 123}I-MIBG imaging detects cardiac involvement and predicts cardiac events in Churg-Strauss syndrome

Abstract

In Churg-Strauss syndrome (CSS) it is important to detect cardiac involvement, which predicts poor prognosis. This study evaluated whether {sup 123}I-metaiodobenzylguanidine (MIBG) scintigraphy could detect cardiac damage and predict cardiac events in CSS. {sup 123}I-MIBG scintigraphy was performed in 28 patients with CSS, 12 of whom had cardiac involvement. The early and delayed heart to mediastinum ratio (early H/M and delayed H/M) and washout rate were calculated by using {sup 123}I-MIBG scintigraphy and compared with those in control subjects. Early H/M and delayed H/M were significantly lower and the washout rate was significantly higher in patients with cardiac involvement than in those without and in controls (early H/M, p = 0.0024, p = 0.0001; delayed H/M, p = 0.0002, p = 0.0001; washout rate, p = 0.0012, p = 0.0052 vs those without and vs controls, respectively). Accuracy for detecting cardiac involvement was 86% for delayed H/M and washout rate and 79% for early H/M and B-type natriuretic peptide (BNP). Kaplan-Meier analysis showed significantly lower cardiac event-free rates in patients with early H/M {<=} 2.18 and BNP > 21.8 pg/ml than those with early H/M > 2.18 and BNP {<=} 21.8 pg/ml (log-rank test p = 0.006). Cardiac sympathetic nerve  More>>
Authors:
Horiguchi, Yoriko; Morita, Yukiko; [1]  Tsurikisawa, Naomi; Akiyama, Kazuo [2] 
  1. National Hospital Organization Sagamihara National Hospital, Department of Cardiology, Sagamihara City, Kanagawa (Japan)
  2. National Hospital Organization Sagamihara National Hospital, Clinical Research Centre for Allergy and Rheumatology, Sagamihara City, Kanagawa (Japan)
Publication Date:
Feb 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: European Journal of Nuclear Medicine and Molecular Imaging; Journal Volume: 38; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; CARDIOVASCULAR DISEASES; ELECTROCARDIOGRAMS; GAMMA CAMERAS; GUANIDINES; IODINE 123; MEDIASTINUM; MYOCARDIUM; NERVOUS SYSTEM; RADIOPHARMACEUTICALS; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; THALLIUM 201
OSTI ID:
21532964
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1619-7070; TRN: DE12F3885
Availability:
Available from: http://dx.doi.org/10.1007/s00259-010-1617-8
Submitting Site:
DEN
Size:
page(s) 221-229
Announcement Date:
Mar 17, 2012

Citation Formats

Horiguchi, Yoriko, Morita, Yukiko, Tsurikisawa, Naomi, and Akiyama, Kazuo. {sup 123}I-MIBG imaging detects cardiac involvement and predicts cardiac events in Churg-Strauss syndrome. Germany: N. p., 2011. Web. doi:10.1007/S00259-010-1617-8.
Horiguchi, Yoriko, Morita, Yukiko, Tsurikisawa, Naomi, & Akiyama, Kazuo. {sup 123}I-MIBG imaging detects cardiac involvement and predicts cardiac events in Churg-Strauss syndrome. Germany. doi:10.1007/S00259-010-1617-8.
Horiguchi, Yoriko, Morita, Yukiko, Tsurikisawa, Naomi, and Akiyama, Kazuo. 2011. "{sup 123}I-MIBG imaging detects cardiac involvement and predicts cardiac events in Churg-Strauss syndrome." Germany. doi:10.1007/S00259-010-1617-8. https://www.osti.gov/servlets/purl/10.1007/S00259-010-1617-8.
@misc{etde_21532964,
title = {{sup 123}I-MIBG imaging detects cardiac involvement and predicts cardiac events in Churg-Strauss syndrome}
author = {Horiguchi, Yoriko, Morita, Yukiko, Tsurikisawa, Naomi, and Akiyama, Kazuo}
abstractNote = {In Churg-Strauss syndrome (CSS) it is important to detect cardiac involvement, which predicts poor prognosis. This study evaluated whether {sup 123}I-metaiodobenzylguanidine (MIBG) scintigraphy could detect cardiac damage and predict cardiac events in CSS. {sup 123}I-MIBG scintigraphy was performed in 28 patients with CSS, 12 of whom had cardiac involvement. The early and delayed heart to mediastinum ratio (early H/M and delayed H/M) and washout rate were calculated by using {sup 123}I-MIBG scintigraphy and compared with those in control subjects. Early H/M and delayed H/M were significantly lower and the washout rate was significantly higher in patients with cardiac involvement than in those without and in controls (early H/M, p = 0.0024, p = 0.0001; delayed H/M, p = 0.0002, p = 0.0001; washout rate, p = 0.0012, p = 0.0052 vs those without and vs controls, respectively). Accuracy for detecting cardiac involvement was 86% for delayed H/M and washout rate and 79% for early H/M and B-type natriuretic peptide (BNP). Kaplan-Meier analysis showed significantly lower cardiac event-free rates in patients with early H/M {<=} 2.18 and BNP > 21.8 pg/ml than those with early H/M > 2.18 and BNP {<=} 21.8 pg/ml (log-rank test p = 0.006). Cardiac sympathetic nerve function was damaged in CSS patients with cardiac involvement. {sup 123}I-MIBG scintigraphy was useful in detecting cardiac involvement and in predicting cardiac events. (orig.)}
doi = {10.1007/S00259-010-1617-8}
journal = {European Journal of Nuclear Medicine and Molecular Imaging}
issue = {2}
volume = {38}
place = {Germany}
year = {2011}
month = {Feb}
}