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Radical chemistry of artemisinin

Abstract

The review summarizes physicochemical characteristics of the natural sesquiterpene peroxide artemisinin. The kinetic schemes of transformations of artemisinin radicals under anaerobic conditions are presented and analyzed. The sequence of radical reactions of artemisinin in the presence of oxygen is considered in detail. Special emphasis is given to the intramolecular chain oxidation resulting in the transformation of artemisinin into polyatomic hydroperoxide. The kinetic characteristics of elementary reaction steps involving alkyl, alkoxyl, and peroxyl radicals generated from artemisinin are discussed. The results of testing of artemisinin and its derivatives for the antimalarial activity and the scheme of the biochemical synthesis of artemisinin in nature are considered.
Authors:
Denisov, Evgenii T; Solodova, S L; Denisova, Taisa G [1] 
  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region (Russian Federation)
Publication Date:
Dec 29, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Russian Chemical Reviews (Print); Journal Volume: 79; Journal Issue: 11; Other Information: DOI: 10.1070/RC2010v079n11ABEH004143
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; CHEMICAL PROPERTIES; CHEMICAL REACTION KINETICS; DRUGS; MALARIA; PEROXY RADICALS; PHYSICAL PROPERTIES; DISEASES; INFECTIOUS DISEASES; KINETICS; PARASITIC DISEASES; RADICALS; REACTION KINETICS
OSTI ID:
21526116
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0036-021X; TRN: GB12P6152005899
Availability:
Available from http://dx.doi.org/10.1070/RC2010v079n11ABEH004143
Submitting Site:
GBN
Size:
page(s) 981-1003
Announcement Date:
Feb 23, 2012

Citation Formats

Denisov, Evgenii T, Solodova, S L, and Denisova, Taisa G. Radical chemistry of artemisinin. United Kingdom: N. p., 2010. Web. doi:10.1070/RC2010V079N11ABEH004143.
Denisov, Evgenii T, Solodova, S L, & Denisova, Taisa G. Radical chemistry of artemisinin. United Kingdom. doi:10.1070/RC2010V079N11ABEH004143.
Denisov, Evgenii T, Solodova, S L, and Denisova, Taisa G. 2010. "Radical chemistry of artemisinin." United Kingdom. doi:10.1070/RC2010V079N11ABEH004143. https://www.osti.gov/servlets/purl/10.1070/RC2010V079N11ABEH004143.
@misc{etde_21526116,
title = {Radical chemistry of artemisinin}
author = {Denisov, Evgenii T, Solodova, S L, and Denisova, Taisa G}
abstractNote = {The review summarizes physicochemical characteristics of the natural sesquiterpene peroxide artemisinin. The kinetic schemes of transformations of artemisinin radicals under anaerobic conditions are presented and analyzed. The sequence of radical reactions of artemisinin in the presence of oxygen is considered in detail. Special emphasis is given to the intramolecular chain oxidation resulting in the transformation of artemisinin into polyatomic hydroperoxide. The kinetic characteristics of elementary reaction steps involving alkyl, alkoxyl, and peroxyl radicals generated from artemisinin are discussed. The results of testing of artemisinin and its derivatives for the antimalarial activity and the scheme of the biochemical synthesis of artemisinin in nature are considered.}
doi = {10.1070/RC2010V079N11ABEH004143}
journal = {Russian Chemical Reviews (Print)}
issue = {11}
volume = {79}
place = {United Kingdom}
year = {2010}
month = {Dec}
}