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Protocol for adaptation of internal dosimetry techniques for planning of individualized doses of {sup 131}I in pediatric patients; Protocolo para adaptacao de tecnicas de dosimetria interna para planejamento de doses individualizadas de {sup 131}I em pacientes pediatricos

Abstract

The optimization of radiation doses is emphasized in diseases with good prognosis, as differentiated thyroid carcinomas, especially in pediatric patients, since the radiation risk is conversely proportional to age. Aiming to establish individual treatment planning, it has been studied four dosimetry methodologies (external dose monitoring, image quantification, urine and blood bioassay) for four 13.3 {+-} 1.5-year-old female patients, who received 107 {+-} 15 MBq (2,9 {+-} 0,4 mCi) for tracer dose and 5.5 {+-} 0.3 GBq (149 {+-} 8 mCi) for thyroid ablation. Effective half-lives, residence times and cumulated activities were estimated in organs and tissues with iodine uptake, through planar images quantification by conjugate-view and attenuation correction, in order to compare biokinetic behavior in tracer dose and ablative dose phases. For external monitoring, two patients had similar whole-body effective half-lives in both phases. For this methodology, despite the uncertainties associated to measurements, equipment used and procedures performed were adequate. For urine bioassay, there were not similarities among the patients whole-body effective half-lives. Through blood bioassay, it was observed that 0.2 % of the administered activity for ablative dose remained in the blood until 76 hours after administration. The external monitoring allowed estimating effective doses in patients mothers by conversion  More>>
Publication Date:
Jul 01, 2011
Product Type:
Thesis/Dissertation
Report Number:
INIS-BR-9708
Resource Relation:
Other Information: Diss. (M.Sc.)
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; CHILDREN; DECAY; DOSIMETRY; HALF-LIFE; IODINE; IODINE 131; LIFETIME; PEDIATRICS; RADIATION INJURIES; RADIATION PROTECTION; RADIOBIOLOGY; SAFETY; THYROID; AGE GROUPS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGY; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; ELEMENTS; ENDOCRINE GLANDS; GLANDS; HALOGENS; INJURIES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; MAN; MEDICINE; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIATION EFFECTS; RADIOISOTOPES; VERTEBRATES
OSTI ID:
21501404
Research Organizations:
Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Coordenacao de Pos-Graduacao
Country of Origin:
Brazil
Language:
Portuguese
Other Identifying Numbers:
TRN: BR11V3008093124
Availability:
Available from INIS in electronic form
Submitting Site:
BRN
Size:
168 pages
Announcement Date:
Nov 11, 2011

Citation Formats

Biancardi, Rodrigo. Protocol for adaptation of internal dosimetry techniques for planning of individualized doses of {sup 131}I in pediatric patients; Protocolo para adaptacao de tecnicas de dosimetria interna para planejamento de doses individualizadas de {sup 131}I em pacientes pediatricos. Brazil: N. p., 2011. Web.
Biancardi, Rodrigo. Protocol for adaptation of internal dosimetry techniques for planning of individualized doses of {sup 131}I in pediatric patients; Protocolo para adaptacao de tecnicas de dosimetria interna para planejamento de doses individualizadas de {sup 131}I em pacientes pediatricos. Brazil.
Biancardi, Rodrigo. 2011. "Protocol for adaptation of internal dosimetry techniques for planning of individualized doses of {sup 131}I in pediatric patients; Protocolo para adaptacao de tecnicas de dosimetria interna para planejamento de doses individualizadas de {sup 131}I em pacientes pediatricos." Brazil.
@misc{etde_21501404,
title = {Protocol for adaptation of internal dosimetry techniques for planning of individualized doses of {sup 131}I in pediatric patients; Protocolo para adaptacao de tecnicas de dosimetria interna para planejamento de doses individualizadas de {sup 131}I em pacientes pediatricos}
author = {Biancardi, Rodrigo}
abstractNote = {The optimization of radiation doses is emphasized in diseases with good prognosis, as differentiated thyroid carcinomas, especially in pediatric patients, since the radiation risk is conversely proportional to age. Aiming to establish individual treatment planning, it has been studied four dosimetry methodologies (external dose monitoring, image quantification, urine and blood bioassay) for four 13.3 {+-} 1.5-year-old female patients, who received 107 {+-} 15 MBq (2,9 {+-} 0,4 mCi) for tracer dose and 5.5 {+-} 0.3 GBq (149 {+-} 8 mCi) for thyroid ablation. Effective half-lives, residence times and cumulated activities were estimated in organs and tissues with iodine uptake, through planar images quantification by conjugate-view and attenuation correction, in order to compare biokinetic behavior in tracer dose and ablative dose phases. For external monitoring, two patients had similar whole-body effective half-lives in both phases. For this methodology, despite the uncertainties associated to measurements, equipment used and procedures performed were adequate. For urine bioassay, there were not similarities among the patients whole-body effective half-lives. Through blood bioassay, it was observed that 0.2 % of the administered activity for ablative dose remained in the blood until 76 hours after administration. The external monitoring allowed estimating effective doses in patients mothers by conversion of the environmental equivalent dose. In the ablative dose phase, the effective doses resulted in 1.3 {+-} 0.3 mSv in the hospital and 0.3 {+-} 0.1 mSv in patients houses. (author)}
place = {Brazil}
year = {2011}
month = {Jul}
}