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'Dose-painting': Myth or reality?; 'Dose-painting': mythe ou realite?

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Abstract

'Dose-painting' radiotherapy allows for a heterogeneous delivery of radiation within the tumour volume by targeting radioresistant areas defined by functional imaging. Within gross tumour volume, it is possible to define one or more target volumes based on biology (biological target volume [BTV]) and to apply a strategy of intensity modulated radiation therapy (IMRT) that will deliver a higher dose to these regions. In this review of the literature, we will highlight the biological elements responsible for radioresistance, and how to image them, then we will detail the radiotherapy techniques necessary for this approach, before presenting clinical results in various situations (head and neck tumours, prostate, brain tumours, etc.). Despite many difficulties that make dose-painting IMRT unusable in routine nowadays, biology-guided radiation therapy represents one of the major pathways of development of radiotherapy in the coming years. (authors)
Authors:
Supiot, S; Paris, F; [1]  Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France); Inserm UMR 892, 44 - Nantes (France)]; Lisbona, A; [2]  Inserm UMR 892, 44 - Nantes (France); Service de radiophysique, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France)]; Azria, D; [3]  Fenoglietto, P [4] 
  1. Service de radiotherapie, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France)
  2. Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France)
  3. Service de radiotherapie, centre Val d'Aurelle Paul-Lamarque, 34 - Montpellier (France)
  4. Service de radiophysique, centre Val d'Aurelle Paul-Lamarque, 34 - Montpellier (France)
Publication Date:
Oct 15, 2010
DOI:
https://doi.org/10.1016/J.CANRAD.2010.06.005
Product Type:
Journal Article
Resource Relation:
Journal Name: Cancer Radiotherapie; Journal Volume: 14; Journal Issue: no.6-7; Conference: 21. national congress of the French society of oncological radiotherapy, 21. Congres national de la Societe Francaise de Radiotherapie Oncologique (SFRO), Paris (France), 6-8 Oct 2010; Other Information: 86 refs.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ACCURACY; ANOXIA; CARCINOMAS; CELL PROLIFERATION; CT-GUIDED RADIOTHERAPY; DOSE-RESPONSE RELATIONSHIPS; EFFICIENCY; GLIOMAS; HODGKINS DISEASE; IMAGE PROCESSING; LUNGS; NMR IMAGING; OPTIMIZATION; POSITRON COMPUTED TOMOGRAPHY; PROSTATE; RADIOSENSITIVITY; RECTUM; SPATIAL DOSE DISTRIBUTIONS; TOXICITY; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; EMISSION COMPUTED TOMOGRAPHY; GASTROINTESTINAL TRACT; GLANDS; IMMUNE SYSTEM DISEASES; INTESTINES; LARGE INTESTINE; LYMPHOMAS; MALE GENITALS; MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEAR MEDICINE; ORGANS; PROCESSING; RADIATION DOSE DISTRIBUTIONS; RADIOLOGY; RADIOTHERAPY; RESPIRATORY SYSTEM; SENSITIVITY; THERAPY; TOMOGRAPHY
OSTI ID:
21489291
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: ISSN 1278-3218; CARAFC; TRN: FR1002156080478
Availability:
Available from doi: <http://dx.doi.org/10.1016/j.canrad.2010.06.005>
Submitting Site:
FRN
Size:
page(s) 554-562
Announcement Date:
Oct 27, 2011

Journal Article:

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Citation Formats

Supiot, S, Paris, F, Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France), Inserm UMR 892, 44 - Nantes (France)], Lisbona, A, Inserm UMR 892, 44 - Nantes (France), Service de radiophysique, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France)], Azria, D, and Fenoglietto, P. 'Dose-painting': Myth or reality?; 'Dose-painting': mythe ou realite?. France: N. p., 2010. Web. doi:10.1016/J.CANRAD.2010.06.005.
Supiot, S, Paris, F, Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France), Inserm UMR 892, 44 - Nantes (France)], Lisbona, A, Inserm UMR 892, 44 - Nantes (France), Service de radiophysique, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France)], Azria, D, & Fenoglietto, P. 'Dose-painting': Myth or reality?; 'Dose-painting': mythe ou realite?. France. https://doi.org/10.1016/J.CANRAD.2010.06.005
Supiot, S, Paris, F, Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France), Inserm UMR 892, 44 - Nantes (France)], Lisbona, A, Inserm UMR 892, 44 - Nantes (France), Service de radiophysique, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France)], Azria, D, and Fenoglietto, P. 2010. "'Dose-painting': Myth or reality?; 'Dose-painting': mythe ou realite?" France. https://doi.org/10.1016/J.CANRAD.2010.06.005.
@misc{etde_21489291,
title = {'Dose-painting': Myth or reality?; 'Dose-painting': mythe ou realite?}
 author = {Supiot, S, Paris, F, Centre de recherche sur le cancer Nantes-Angers (CRCNA), institut de recherche therapeutique, universite de Nantes, 44 - Nantes (France), Inserm UMR 892, 44 - Nantes (France)], Lisbona, A, Inserm UMR 892, 44 - Nantes (France), Service de radiophysique, centre Rene-Gauducheau, 44 - Nantes-St-Herblain (France)], Azria, D, and Fenoglietto, P}
 abstractNote = {'Dose-painting' radiotherapy allows for a heterogeneous delivery of radiation within the tumour volume by targeting radioresistant areas defined by functional imaging. Within gross tumour volume, it is possible to define one or more target volumes based on biology (biological target volume [BTV]) and to apply a strategy of intensity modulated radiation therapy (IMRT) that will deliver a higher dose to these regions. In this review of the literature, we will highlight the biological elements responsible for radioresistance, and how to image them, then we will detail the radiotherapy techniques necessary for this approach, before presenting clinical results in various situations (head and neck tumours, prostate, brain tumours, etc.). Despite many difficulties that make dose-painting IMRT unusable in routine nowadays, biology-guided radiation therapy represents one of the major pathways of development of radiotherapy in the coming years. (authors)}
 doi = {10.1016/J.CANRAD.2010.06.005}
 journal = []
 issue = {no.6-7}
 volume = {14}
 place = {France}
 year = {2010}
 month = {Oct}
 }