Abstract
In this article, we describe two possible applications of low-intensity non-ionizing electromagnetic fields (EMF) for the treatment of malaria and cancer, respectively. In malaria treatment, a low-intensity extremely-low frequency magnetic field can be used to induce vibration of hemozoin, a super-paramagnetic polymer particle, inside malaria parasites. This disturbance could cause free radical and mechanical damages leading to the death of the parasite. This concept has been tested in vitro on malaria parasites and found to be effective. This may provide a low cost effective treatment for malaria infection in humans. The rationale for cancer treatment using low-intensity EMF is based on two concepts that have been well established in the literature: (1) low-intensity non-thermal EMF enhances cytotoxic free radicals via the iron-mediated Fenton reaction; and (2) cancer cells have higher amounts of free iron, thus are more susceptible to the cytotoxic effects of EMF. Since normal cells contain minimal amount of free iron, the effect would be selectively targeting cancer cells. Thus, no adverse side effect would be expected as in traditional chemotherapy and radiation therapy. This concept has also been tested on human cancer cell and normal cells in vitro and proved to be feasible.
Lai, Henry C;
Singh, Narendra P, E-mail: hlai@u.washington.ed
[1]
- Department of Bioengineering, University of Washington, Seattle, WA 98195-5061 (United States)
Citation Formats
Lai, Henry C, and Singh, Narendra P, E-mail: hlai@u.washington.ed.
Medical applications of electromagnetic fields.
United Kingdom: N. p.,
2010.
Web.
doi:10.1088/1755-1315/10/1/012006.
Lai, Henry C, & Singh, Narendra P, E-mail: hlai@u.washington.ed.
Medical applications of electromagnetic fields.
United Kingdom.
https://doi.org/10.1088/1755-1315/10/1/012006
Lai, Henry C, and Singh, Narendra P, E-mail: hlai@u.washington.ed.
2010.
"Medical applications of electromagnetic fields."
United Kingdom.
https://doi.org/10.1088/1755-1315/10/1/012006.
@misc{etde_21486061,
title = {Medical applications of electromagnetic fields}
author = {Lai, Henry C, and Singh, Narendra P, E-mail: hlai@u.washington.ed}
abstractNote = {In this article, we describe two possible applications of low-intensity non-ionizing electromagnetic fields (EMF) for the treatment of malaria and cancer, respectively. In malaria treatment, a low-intensity extremely-low frequency magnetic field can be used to induce vibration of hemozoin, a super-paramagnetic polymer particle, inside malaria parasites. This disturbance could cause free radical and mechanical damages leading to the death of the parasite. This concept has been tested in vitro on malaria parasites and found to be effective. This may provide a low cost effective treatment for malaria infection in humans. The rationale for cancer treatment using low-intensity EMF is based on two concepts that have been well established in the literature: (1) low-intensity non-thermal EMF enhances cytotoxic free radicals via the iron-mediated Fenton reaction; and (2) cancer cells have higher amounts of free iron, thus are more susceptible to the cytotoxic effects of EMF. Since normal cells contain minimal amount of free iron, the effect would be selectively targeting cancer cells. Thus, no adverse side effect would be expected as in traditional chemotherapy and radiation therapy. This concept has also been tested on human cancer cell and normal cells in vitro and proved to be feasible.}
doi = {10.1088/1755-1315/10/1/012006}
journal = []
issue = {1}
volume = {10}
place = {United Kingdom}
year = {2010}
month = {Apr}
}
title = {Medical applications of electromagnetic fields}
author = {Lai, Henry C, and Singh, Narendra P, E-mail: hlai@u.washington.ed}
abstractNote = {In this article, we describe two possible applications of low-intensity non-ionizing electromagnetic fields (EMF) for the treatment of malaria and cancer, respectively. In malaria treatment, a low-intensity extremely-low frequency magnetic field can be used to induce vibration of hemozoin, a super-paramagnetic polymer particle, inside malaria parasites. This disturbance could cause free radical and mechanical damages leading to the death of the parasite. This concept has been tested in vitro on malaria parasites and found to be effective. This may provide a low cost effective treatment for malaria infection in humans. The rationale for cancer treatment using low-intensity EMF is based on two concepts that have been well established in the literature: (1) low-intensity non-thermal EMF enhances cytotoxic free radicals via the iron-mediated Fenton reaction; and (2) cancer cells have higher amounts of free iron, thus are more susceptible to the cytotoxic effects of EMF. Since normal cells contain minimal amount of free iron, the effect would be selectively targeting cancer cells. Thus, no adverse side effect would be expected as in traditional chemotherapy and radiation therapy. This concept has also been tested on human cancer cell and normal cells in vitro and proved to be feasible.}
doi = {10.1088/1755-1315/10/1/012006}
journal = []
issue = {1}
volume = {10}
place = {United Kingdom}
year = {2010}
month = {Apr}
}