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Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia

Abstract

Quantitative analysis of myocardial perfusion MRI can provide noninvasive assessments of myocardial perfusion reserve (MPR), which is associated with endothelial function. Endothelial function is influenced by various factors, including hypertension, diabetes, dyslipidemia, renal dysfunction and anemia. The purpose of this study was to evaluate which risk factor is the strongest effector of MPR in subjects without regional myocardial ischemia. We studied 110 patients (66 years {+-}10, male 68%, hypertension 76%, diabetes mellitus (DM) 40% and dyslipidemia 65%) without regional myocardial ischemia. Adenosine triphosphate (ATP) stress and rest first-pass perfusion magnetic resonance (MR) images were acquired with a 1.5-T MR system, and MPR was calculated as the ratio of stress to rest myocardial blood flow (MBF). Average rest MBF in 110 patients was 1.07{+-}0.62 ml min{sup -1} g{sup -1}, whereas stress MBF was 3.15{+-}1.93 ml min{sup -1} g{sup -1} and the MPR was 3.33{+-}1.82. Rest MBF correlated significantly with hematocrit, whereas stress MBF showed a strong correlation with estimated glomerular filtration rate (e-GFR). MPR was associated with hypertension, age, e-GFR, hematocrit and left ventricular mass index (LVMI). In multiple regression analysis, hypertension (P=0.003, {beta}=-0.274) showed the strongest correlation with MPR among other risk factors, such as diabetes (P=ns), dyslipidemia (P=ns), e-GFR  More>>
Authors:
Nakajima, Hiroshi; Onishi, Katsuya; Kurita, Tairo [1] 
  1. Mie Univ., Graduate School of Medicine, Tsu, Mie (Japan)
Publication Date:
Nov 15, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Hypertension Research; Journal Volume: 33; Journal Issue: 11
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ATP; BIOLOGICAL STRESS; BLOOD FLOW; DTPA; DYNAMIC FUNCTION STUDIES; GADOLINIUM COMPLEXES; HYPERTENSION; ISCHEMIA; MYOCARDIUM; NMR IMAGING; PATIENTS; REGRESSION ANALYSIS; AMINO ACIDS; ANEMIAS; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CHELATING AGENTS; COMPLEXES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; HEART; HEMIC DISEASES; MATHEMATICS; MUSCLES; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOPROTECTIVE SUBSTANCES; RARE EARTH COMPLEXES; RESPONSE MODIFYING FACTORS; STATISTICS; SYMPTOMS; VASCULAR DISEASES
OSTI ID:
21469961
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0916-9636; TRN: JP1102080063213
Submitting Site:
INIS
Size:
page(s) 1144-1149
Announcement Date:
Aug 18, 2011

Citation Formats

Nakajima, Hiroshi, Onishi, Katsuya, and Kurita, Tairo. Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia. Japan: N. p., 2010. Web. doi:10.1038/hr.2010.140.
Nakajima, Hiroshi, Onishi, Katsuya, & Kurita, Tairo. Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia. Japan. https://doi.org/10.1038/hr.2010.140
Nakajima, Hiroshi, Onishi, Katsuya, and Kurita, Tairo. 2010. "Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia." Japan. https://doi.org/10.1038/hr.2010.140.
@misc{etde_21469961,
title = {Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia}
author = {Nakajima, Hiroshi, Onishi, Katsuya, and Kurita, Tairo}
abstractNote = {Quantitative analysis of myocardial perfusion MRI can provide noninvasive assessments of myocardial perfusion reserve (MPR), which is associated with endothelial function. Endothelial function is influenced by various factors, including hypertension, diabetes, dyslipidemia, renal dysfunction and anemia. The purpose of this study was to evaluate which risk factor is the strongest effector of MPR in subjects without regional myocardial ischemia. We studied 110 patients (66 years {+-}10, male 68%, hypertension 76%, diabetes mellitus (DM) 40% and dyslipidemia 65%) without regional myocardial ischemia. Adenosine triphosphate (ATP) stress and rest first-pass perfusion magnetic resonance (MR) images were acquired with a 1.5-T MR system, and MPR was calculated as the ratio of stress to rest myocardial blood flow (MBF). Average rest MBF in 110 patients was 1.07{+-}0.62 ml min{sup -1} g{sup -1}, whereas stress MBF was 3.15{+-}1.93 ml min{sup -1} g{sup -1} and the MPR was 3.33{+-}1.82. Rest MBF correlated significantly with hematocrit, whereas stress MBF showed a strong correlation with estimated glomerular filtration rate (e-GFR). MPR was associated with hypertension, age, e-GFR, hematocrit and left ventricular mass index (LVMI). In multiple regression analysis, hypertension (P=0.003, {beta}=-0.274) showed the strongest correlation with MPR among other risk factors, such as diabetes (P=ns), dyslipidemia (P=ns), e-GFR (P=ns), LVMI (P=0.007, {beta}=-0.248) and hematocrit (P=ns) after adjusting age and gender. Hypertension is the most important effector of MPR in subjects without myocardial ischemia. (author)}
doi = {10.1038/hr.2010.140}
journal = []
issue = {11}
volume = {33}
place = {Japan}
year = {2010}
month = {Nov}
}