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Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses

Journal Article:

Abstract

Stroke Acute Management with Urgent Risk-factor Assessment and Improvement [SAMURAI] rt-PA Registry is a multicenter retrospective observational study from 10 Japanese stroke centers. A total of 600 patients (223 women, 72{+-}12 years old) treated with intravenous alteplase (0.6 mg/kg) were studied. Symptomatic intracerebral hemorrhage within 36 hours with {>=}4 point-increase from the baseline National Institutes of Health (NIH) Stroke Scale score developed in 8 patients (1.3%, 95% confidence interval (CI) 0.7-2.6%). At 3 months, 199 patients (33.2%, 29.5-37.0%) had a modified Rankin Scale (mRS) score {<=}1. Analysis of 399 patients with a premorbid mRS score {<=}1 who met the criteria of the European license ({<=}80 years old, an initial NIHSS score {<=}24, etc.) showed that 40.6% (35.9-45.5%) had a 3-month mRS {<=}1. In the subanalyses from this registry, early ischemic change on diffusion-weighted imaging assessed by the Alberta Stroke Programme Early CT Score, as well as reduced estimated glomerular filtration rate, was associated with early intracerebral hemorrhage and 3-month outcomes of patients. (author)
Authors:
Toyoda, Kazunori; Koga, Masatoshi; [1]  Shiokawa, Yoshiaki [2] 
  1. National Cerebral and Cardiovascular Center, Suita, Osaka (Japan)
  2. Kyorin Univ., School of Medicine, Mitaka, Tokyo (Japan)
Publication Date:
Nov 15, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: No Sotchu; Journal Volume: 32; Journal Issue: 6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CAROTID ARTERIES; CAT SCANNING; CEREBRAL ARTERIES; CLINICAL TRIALS; DIFFUSION; HEMORRHAGE; ISCHEMIA; MULTIVARIATE ANALYSIS; NMR IMAGING; PATIENTS; ANEMIAS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; HEMIC DISEASES; MATHEMATICS; ORGANS; PATHOLOGICAL CHANGES; STATISTICS; SYMPTOMS; TESTING; TOMOGRAPHY; VASCULAR DISEASES
OSTI ID:
21469910
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0912-0726; TRN: JP1102029063162
Submitting Site:
INIS
Size:
page(s) 756-761
Announcement Date:
Aug 17, 2011

Journal Article:

Citation Formats

Toyoda, Kazunori, Koga, Masatoshi, and Shiokawa, Yoshiaki. Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses. Japan: N. p., 2010. Web. doi:10.3995/jstroke.32.756.
Toyoda, Kazunori, Koga, Masatoshi, & Shiokawa, Yoshiaki. Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses. Japan. doi:10.3995/jstroke.32.756.
Toyoda, Kazunori, Koga, Masatoshi, and Shiokawa, Yoshiaki. 2010. "Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses." Japan. doi:10.3995/jstroke.32.756. https://www.osti.gov/servlets/purl/10.3995/jstroke.32.756.
@misc{etde_21469910,
title = {Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses}
author = {Toyoda, Kazunori, Koga, Masatoshi, and Shiokawa, Yoshiaki}
abstractNote = {Stroke Acute Management with Urgent Risk-factor Assessment and Improvement [SAMURAI] rt-PA Registry is a multicenter retrospective observational study from 10 Japanese stroke centers. A total of 600 patients (223 women, 72{+-}12 years old) treated with intravenous alteplase (0.6 mg/kg) were studied. Symptomatic intracerebral hemorrhage within 36 hours with {>=}4 point-increase from the baseline National Institutes of Health (NIH) Stroke Scale score developed in 8 patients (1.3%, 95% confidence interval (CI) 0.7-2.6%). At 3 months, 199 patients (33.2%, 29.5-37.0%) had a modified Rankin Scale (mRS) score {<=}1. Analysis of 399 patients with a premorbid mRS score {<=}1 who met the criteria of the European license ({<=}80 years old, an initial NIHSS score {<=}24, etc.) showed that 40.6% (35.9-45.5%) had a 3-month mRS {<=}1. In the subanalyses from this registry, early ischemic change on diffusion-weighted imaging assessed by the Alberta Stroke Programme Early CT Score, as well as reduced estimated glomerular filtration rate, was associated with early intracerebral hemorrhage and 3-month outcomes of patients. (author)}
doi = {10.3995/jstroke.32.756}
journal = {No Sotchu}
issue = {6}
volume = {32}
place = {Japan}
year = {2010}
month = {Nov}
}