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Serum Leptin and Adiponectin Levels in Breast Cancer Before and After Post Mastectomy Radiotherapy

Journal Article:

Abstract

Obesity is a risk factor for postmenopausal breast cancer and is associated with poor prognosis. Leptin and adiponectin are cytokines synthesized in adipose tissue and have been implicated as a link between obesity and breast cancer. Therefore, in this study we analyzed and compared: serum leptin, adiponectin, lipid profile including cholesterol, triglycerides (TG), high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) and body mass index (BMI) in breast cancer patients before and after Post Mastectomy Radio- therapy (PMRT).Serum leptin and adiponectin significantly increased and decreased respectively in patients after PMRT compared to the controls. BMI statistically decreased after radiotherapy while LDL-c increased in breast cancer patients; in both patients groups. HDL-c was statistically decreased but triglycerides showed significant increase in breast cancer patients. These results denoted that dyslipidemia may be associated with breast cancer risk and the evaluation of leptin and adiponectin can be used for follow up of patients under radiotherapy treatment for breast cancer
Authors:
Nosseir, N M; Abdel -Messeih, Ph L; Mohamed, S.K., E-mail: neveennosseir@Live.co [1] 
  1. Health Radiation Research Department, National Center for Radiation Research and Technology, P.O.Box:29 Nasr City-Cairo (Egypt)
Publication Date:
Jul 01, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of Radiation Research and Applied Sciences; Journal Volume: 3; Journal Issue: 4B
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADIPOSE TISSUE; BLOOD SERUM; CHOLESTEROL; DISEASE INCIDENCE; HAZARDS; HORMONES; IMMUNITY; LIPIDS; LIPOPROTEINS; LYMPHOKINES; MAMMARY GLANDS; METABOLIC DISEASES; NEOPLASMS; PATIENTS; RADIOTHERAPY; TRIGLYCERIDES; ANIMAL TISSUES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CONNECTIVE TISSUE; DISEASES; ESTERS; GLANDS; GROWTH FACTORS; HYDROXY COMPOUNDS; MATERIALS; MEDICINE; MITOGENS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOLOGY; STEROIDS; STEROLS; THERAPY
OSTI ID:
21463739
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1687-8507; TRN: EG1100380057559
Submitting Site:
INIS
Size:
page(s) 1225-1236
Announcement Date:
Aug 02, 2011

Journal Article:

Citation Formats

Nosseir, N M, Abdel -Messeih, Ph L, and Mohamed, S.K., E-mail: neveennosseir@Live.co. Serum Leptin and Adiponectin Levels in Breast Cancer Before and After Post Mastectomy Radiotherapy. Egypt: N. p., 2010. Web.
Nosseir, N M, Abdel -Messeih, Ph L, & Mohamed, S.K., E-mail: neveennosseir@Live.co. Serum Leptin and Adiponectin Levels in Breast Cancer Before and After Post Mastectomy Radiotherapy. Egypt.
Nosseir, N M, Abdel -Messeih, Ph L, and Mohamed, S.K., E-mail: neveennosseir@Live.co. 2010. "Serum Leptin and Adiponectin Levels in Breast Cancer Before and After Post Mastectomy Radiotherapy." Egypt.
@misc{etde_21463739,
title = {Serum Leptin and Adiponectin Levels in Breast Cancer Before and After Post Mastectomy Radiotherapy}
author = {Nosseir, N M, Abdel -Messeih, Ph L, and Mohamed, S.K., E-mail: neveennosseir@Live.co}
abstractNote = {Obesity is a risk factor for postmenopausal breast cancer and is associated with poor prognosis. Leptin and adiponectin are cytokines synthesized in adipose tissue and have been implicated as a link between obesity and breast cancer. Therefore, in this study we analyzed and compared: serum leptin, adiponectin, lipid profile including cholesterol, triglycerides (TG), high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) and body mass index (BMI) in breast cancer patients before and after Post Mastectomy Radio- therapy (PMRT).Serum leptin and adiponectin significantly increased and decreased respectively in patients after PMRT compared to the controls. BMI statistically decreased after radiotherapy while LDL-c increased in breast cancer patients; in both patients groups. HDL-c was statistically decreased but triglycerides showed significant increase in breast cancer patients. These results denoted that dyslipidemia may be associated with breast cancer risk and the evaluation of leptin and adiponectin can be used for follow up of patients under radiotherapy treatment for breast cancer}
journal = {Journal of Radiation Research and Applied Sciences}
issue = {4B}
volume = {3}
place = {Egypt}
year = {2010}
month = {Jul}
}