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Metformin therapy prevents early pregnancy loss in polycystic ovarian syndrome

Journal Article:

Abstract

Background: The study was done to compare the early pregnancy loss rate in women with polycystic ovarian syndrome who received or did not receive metformin in pregnancy. Study type, settings and duration: A case control interventional study carried out at Civil Hospital Karachi, Hamdard University Hospital and Private Gynaecology clinics from January 2005 to July 2008. Subjects and Methods Eighty two non diabetic patients with polycystic ovarian syndrome who became pregnant were included in the study. A questionnaire was filled for all patients that included information on basic demography and mean age, parity, weight. Fasting blood sugar and serum insulin levels were done for all these women. Only patients with raised insulin levels (more than 10 mu/l) were included in the study and all were offered to use oral metformin throughout pregnancy as 500 mg three times a day with folic acid supplements 5 mg once daily. Those who agreed to take the drug throughout pregnancy and to comply with the therapy were taken as cases, while those who did not agree to take the medicine acted as controls. Patients with other causes of recurrent pregnancy loss were excluded from the study. All pregnancies were followed using serial ultrasound examination  More>>
Authors:
Hassan, J A; Anbareen, T; [1]  Anbareen, T [2] 
  1. Dow University of Health Sciences, Karachi (Pakistan). Dept. of Gynae
  2. Hamdard University Hospital, Karachi (Pakistan)
Publication Date:
Jan 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Pakistan Journal of Medical Research; Journal Volume: 50; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; INSULIN; MENSTRUATION DISORDERS; METASTABLE STATES; OVARIES; PREGNANCY; ULTRASONOGRAPHY; WOMEN; ANIMALS; BODY; DIAGNOSTIC TECHNIQUES; DISEASES; ENERGY LEVELS; EXCITED STATES; FEMALE GENITALS; FEMALES; GONADS; HORMONES; MAMMALS; MAN; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PRIMATES; PROTEINS; UROGENITAL SYSTEM DISEASES; VERTEBRATES
OSTI ID:
21459478
Country of Origin:
Pakistan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0030-9842; TRN: PK1100450055351
Submitting Site:
INIS
Size:
page(s) 1-4
Announcement Date:
Aug 02, 2011

Journal Article:

Citation Formats

Hassan, J A, Anbareen, T, and Anbareen, T. Metformin therapy prevents early pregnancy loss in polycystic ovarian syndrome. Pakistan: N. p., 2011. Web.
Hassan, J A, Anbareen, T, & Anbareen, T. Metformin therapy prevents early pregnancy loss in polycystic ovarian syndrome. Pakistan.
Hassan, J A, Anbareen, T, and Anbareen, T. 2011. "Metformin therapy prevents early pregnancy loss in polycystic ovarian syndrome." Pakistan.
@misc{etde_21459478,
title = {Metformin therapy prevents early pregnancy loss in polycystic ovarian syndrome}
author = {Hassan, J A, Anbareen, T, and Anbareen, T}
abstractNote = {Background: The study was done to compare the early pregnancy loss rate in women with polycystic ovarian syndrome who received or did not receive metformin in pregnancy. Study type, settings and duration: A case control interventional study carried out at Civil Hospital Karachi, Hamdard University Hospital and Private Gynaecology clinics from January 2005 to July 2008. Subjects and Methods Eighty two non diabetic patients with polycystic ovarian syndrome who became pregnant were included in the study. A questionnaire was filled for all patients that included information on basic demography and mean age, parity, weight. Fasting blood sugar and serum insulin levels were done for all these women. Only patients with raised insulin levels (more than 10 mu/l) were included in the study and all were offered to use oral metformin throughout pregnancy as 500 mg three times a day with folic acid supplements 5 mg once daily. Those who agreed to take the drug throughout pregnancy and to comply with the therapy were taken as cases, while those who did not agree to take the medicine acted as controls. Patients with other causes of recurrent pregnancy loss were excluded from the study. All pregnancies were followed using serial ultrasound examination to see any pregnancy loss in the two groups. Eighty two cases of polycystic ovaries with pregnancy were seen during the study period. All cases had raised serum insulin levels. Fifty patients agreed to take metformin through out pregnancy while, 32 cases did not agree to take metformin during pregnancy and thus acted as controls. The two groups did not differ in mean age, parity, weight and mean fasting blood sugar levels. Fasting insulin levels were high in metformin group (18.40 mu/l ) than in controls (12.53 mu/l). Missed abortion rate was significantly lower (12%) in metformin group than in controls (28%) (p<0.028). No congenital anomalies were found in both the groups on ultrasound at 16-19 weeks. Metformin treatment during pregnancy significantly reduced the rate of early pregnancy loss in women with polycystic ovarian syndrome. Metformin should be given during pregnancy in cases having polycystic ovarian syndrome with high insulin levels. (author)}
journal = {Pakistan Journal of Medical Research}
issue = {1}
volume = {50}
place = {Pakistan}
year = {2011}
month = {Jan}
}