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Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques

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Abstract

Purpose: To describe the degradation effects produced by respiratory organ and lesion motion on PET/CT images and to define the role of respiratory gated (RG) 4D-PET/CT techniques to compensate for such effects. Methods: Based on the literature and on our own experience, technical recommendations and clinical indications for the use of RG 4D PET/CT have been outlined. Results: RG 4D-PET/CT techniques require a state of the art PET/CT scanner, a respiratory monitoring system and dedicated acquisition and processing protocols. Patient training is particularly important to obtain a regular breathing pattern. An adequate number of phases has to be selected to balance motion compensation and statistical noise. RG 4D PET/CT motion free images may be clinically useful for tumour tissue characterization, monitoring patient treatment and target definition in radiation therapy planning. Conclusions: RG 4D PET/CT is a valuable tool to improve image quality and quantitative accuracy and to assess and measure organ and lesion motion for radiotherapy planning.
Authors:
Bettinardi, Valentino; [1]  Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)]; Picchio, Maria; [1]  Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)]; Di Muzio, Nadia; [2]  Gianolli, Luigi; [1]  Gilardi, Maria Carla; [1]  Center for Molecular Bioimaging, University of Milano-Bicocca, Milan (Italy); Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)]; Messa, Cristina; [3]  Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy); Nuclear Medicine, San Gerardo Hospital, Monza (Italy); L.A.T.O., HSR-Giglio, Cefalu (Italy)]
  1. Nuclear Medicine, San Raffaele Scientific Institute, Milan (Italy)
  2. Radiotherapy, San Raffaele Scientific Institute, Milan (Italy)
  3. Center for Molecular Bioimaging, University of Milano-Bicocca, Milan (Italy)
Publication Date:
Sep 15, 2010
DOI:
https://doi.org/10.1016/j.radonc.2010.07.014
Product Type:
Journal Article
Resource Relation:
Journal Name: Radiotherapy and Oncology; Journal Volume: 96; Journal Issue: 3; Other Information: DOI: 10.1016/j.radonc.2010.07.014; PII: S0167-8140(10)00421-4; Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CAT SCANNING; DETECTION; FOUR-DIMENSIONAL CALCULATIONS; PLANNING; POSITRON COMPUTED TOMOGRAPHY; RADIOTHERAPY; TRAINING; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EDUCATION; EMISSION COMPUTED TOMOGRAPHY; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; THERAPY; TOMOGRAPHY
OSTI ID:
21435290
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0167-8140; RAONDT; TRN: IE10R0286030795
Availability:
Available from http://dx.doi.org/10.1016/j.radonc.2010.07.014
Submitting Site:
INIS
Size:
page(s) 311-316
Announcement Date:
Jun 06, 2011

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Citation Formats

Bettinardi, Valentino, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Picchio, Maria, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Di Muzio, Nadia, Gianolli, Luigi, Gilardi, Maria Carla, Center for Molecular Bioimaging, University of Milano-Bicocca, Milan (Italy), Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Messa, Cristina, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy), Nuclear Medicine, San Gerardo Hospital, Monza (Italy), and L.A.T.O., HSR-Giglio, Cefalu (Italy)]. Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques. Ireland: N. p., 2010. Web. doi:10.1016/j.radonc.2010.07.014.
Bettinardi, Valentino, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Picchio, Maria, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Di Muzio, Nadia, Gianolli, Luigi, Gilardi, Maria Carla, Center for Molecular Bioimaging, University of Milano-Bicocca, Milan (Italy), Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Messa, Cristina, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy), Nuclear Medicine, San Gerardo Hospital, Monza (Italy), & L.A.T.O., HSR-Giglio, Cefalu (Italy)]. Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques. Ireland. https://doi.org/10.1016/j.radonc.2010.07.014
Bettinardi, Valentino, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Picchio, Maria, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Di Muzio, Nadia, Gianolli, Luigi, Gilardi, Maria Carla, Center for Molecular Bioimaging, University of Milano-Bicocca, Milan (Italy), Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Messa, Cristina, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy), Nuclear Medicine, San Gerardo Hospital, Monza (Italy), and L.A.T.O., HSR-Giglio, Cefalu (Italy)]. 2010. "Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques." Ireland. https://doi.org/10.1016/j.radonc.2010.07.014.
@misc{etde_21435290,
title = {Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques}
 author = {Bettinardi, Valentino, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Picchio, Maria, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Di Muzio, Nadia, Gianolli, Luigi, Gilardi, Maria Carla, Center for Molecular Bioimaging, University of Milano-Bicocca, Milan (Italy), Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy)], Messa, Cristina, Institute for Bioimaging and Molecular Physiology, National Research Council, Milan (Italy), Nuclear Medicine, San Gerardo Hospital, Monza (Italy), and L.A.T.O., HSR-Giglio, Cefalu (Italy)]}
 abstractNote = {Purpose: To describe the degradation effects produced by respiratory organ and lesion motion on PET/CT images and to define the role of respiratory gated (RG) 4D-PET/CT techniques to compensate for such effects. Methods: Based on the literature and on our own experience, technical recommendations and clinical indications for the use of RG 4D PET/CT have been outlined. Results: RG 4D-PET/CT techniques require a state of the art PET/CT scanner, a respiratory monitoring system and dedicated acquisition and processing protocols. Patient training is particularly important to obtain a regular breathing pattern. An adequate number of phases has to be selected to balance motion compensation and statistical noise. RG 4D PET/CT motion free images may be clinically useful for tumour tissue characterization, monitoring patient treatment and target definition in radiation therapy planning. Conclusions: RG 4D PET/CT is a valuable tool to improve image quality and quantitative accuracy and to assess and measure organ and lesion motion for radiotherapy planning.}
 doi = {10.1016/j.radonc.2010.07.014}
 journal = []
 issue = {3}
 volume = {96}
 place = {Ireland}
 year = {2010}
 month = {Sep}
 }