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The multi-slice CT perfusion imaging in evaluating the prevention and treatment by edaravone on lung ischemia-reperfusion injury after pulmonary thromboembolism

Journal Article:

Abstract

Objective: To evaluate the multi-slice CT perfusion imaging in investigating whether edaravone can prevent and treat pulmonary thromboembolism ischemia-reperfusion injury (PTE-IRI). Methods: Twenty mongrel canines were included. A Swan-Ganz catheter was introduced into the right internal jugular vein using the Seldinger technique, and then was inserted into the pulmonary artery. Balloon occlusion of the right inferior lobe pulmonary artery for 4 h was followed by removing catheter and 4 h o reperfusion. Animals were divided into four groups of A (no edaravone during ischenmia and reperfusion), B (edaravone used only during ischemia), C (edaravone used during both ischemia and reperfusion) and D group (edaravone used only during reperfusion) (n=5 per group). Every group was divided into three time points including before ischemia, 4 h after ischemia and 4 h after reperfusion. CT scan and CT perfusion were performed at the three time points. The blood flow (BF), blood volume (BV) and mean transit time (MTT) of the bilateral inferior regional lung parenchyma were measured with the software of perfusion 3. Results: CT examination showed pulmonary edema in the right inferior lung lobe at 4 h after reperfusion. (1) The BF and MTT of A, B, C and D group were[(259.4{+-}15.7)ml{center_dot}min{sup  More>>
Authors:
Jianjun, Li; Renyou, Zhai; Dongpo, Zhang; Qiang, Huang; Dingke, Dai; Ping, Yu; Na, Bao [1] 
  1. Department of Radiology, Beijing Chaoyang Hospital, Capital Medical Univ., Beijing (China)
Publication Date:
Oct 15, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Chinese Journal of Radiology; Journal Volume: 42; Journal Issue: 10; Other Information: 9 figs., 5 tabs., 6 refs.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; BLOOD FLOW; CAT SCANNING; DIAGNOSIS; DOGS; EDEMA; EMBOLI; INJURIES; ISCHEMIA; LUNGS; PERFUSED ORGANS; VEINS; ANEMIAS; ANIMALS; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; HEMIC DISEASES; MAMMALS; ORGANS; PATHOLOGICAL CHANGES; RESPIRATORY SYSTEM; SYMPTOMS; TOMOGRAPHY; VASCULAR DISEASES; VERTEBRATES
OSTI ID:
21404148
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 1005-1201; TRN: CN1003371129851
Submitting Site:
INIS
Size:
page(s) 1089-1094
Announcement Date:
Mar 26, 2011

Journal Article:

Citation Formats

Jianjun, Li, Renyou, Zhai, Dongpo, Zhang, Qiang, Huang, Dingke, Dai, Ping, Yu, and Na, Bao. The multi-slice CT perfusion imaging in evaluating the prevention and treatment by edaravone on lung ischemia-reperfusion injury after pulmonary thromboembolism. China: N. p., 2008. Web.
Jianjun, Li, Renyou, Zhai, Dongpo, Zhang, Qiang, Huang, Dingke, Dai, Ping, Yu, & Na, Bao. The multi-slice CT perfusion imaging in evaluating the prevention and treatment by edaravone on lung ischemia-reperfusion injury after pulmonary thromboembolism. China.
Jianjun, Li, Renyou, Zhai, Dongpo, Zhang, Qiang, Huang, Dingke, Dai, Ping, Yu, and Na, Bao. 2008. "The multi-slice CT perfusion imaging in evaluating the prevention and treatment by edaravone on lung ischemia-reperfusion injury after pulmonary thromboembolism." China.
@misc{etde_21404148,
title = {The multi-slice CT perfusion imaging in evaluating the prevention and treatment by edaravone on lung ischemia-reperfusion injury after pulmonary thromboembolism}
author = {Jianjun, Li, Renyou, Zhai, Dongpo, Zhang, Qiang, Huang, Dingke, Dai, Ping, Yu, and Na, Bao}
abstractNote = {Objective: To evaluate the multi-slice CT perfusion imaging in investigating whether edaravone can prevent and treat pulmonary thromboembolism ischemia-reperfusion injury (PTE-IRI). Methods: Twenty mongrel canines were included. A Swan-Ganz catheter was introduced into the right internal jugular vein using the Seldinger technique, and then was inserted into the pulmonary artery. Balloon occlusion of the right inferior lobe pulmonary artery for 4 h was followed by removing catheter and 4 h o reperfusion. Animals were divided into four groups of A (no edaravone during ischenmia and reperfusion), B (edaravone used only during ischemia), C (edaravone used during both ischemia and reperfusion) and D group (edaravone used only during reperfusion) (n=5 per group). Every group was divided into three time points including before ischemia, 4 h after ischemia and 4 h after reperfusion. CT scan and CT perfusion were performed at the three time points. The blood flow (BF), blood volume (BV) and mean transit time (MTT) of the bilateral inferior regional lung parenchyma were measured with the software of perfusion 3. Results: CT examination showed pulmonary edema in the right inferior lung lobe at 4 h after reperfusion. (1) The BF and MTT of A, B, C and D group were[(259.4{+-}15.7)ml{center_dot}min{sup -1{center_dot}}100 g{sup -1}, (293.7{+-} 7.9) ml{center_dot}min{sup -1{center_dot}}100 g {sup -1}, (379.4{+-}14.5)ml{center_dot}min{sup -1{center_dot}}100 g{sup -1}, (382.5{+-}16.6)ml{center_dot}min{sup -1{center_dot}}. 100 g{sup -1}] and [(3.1{+-}0.2)s, (2.6{+-}0.2)s, (2.2{+-}0.1)s, (1.9{+-}0.2)s] respectively at 4 h after reperfusion. The BF and MTT were statistically different (P<0.01) between groups (A and B, A and C, A and D, B and C, B and D) except between group C and D (the P value >0.05) at 4 h after reperfusion, but the BV was not statistically different between groups (P>0.05). (2) The BF [(397.2{+-} 19.2)ml{center_dot}min{sup -1{center_dot}}100 g{sup -1} and (259.4{+-}15.7) ml{center_dot}min{sup -1{center_dot}}100 g{sup -1} in group A, (393.2{+-}16.1) ml{center_dot} min{sup -1{center_dot}}100 g{sup -1} and (293.7{+-}7.9) ml{center_dot}min{sup -1{center_dot}}100 g{sup -1} in group B] and MTF [(1.8{+-}0.1)s and (3.1{+-}0.2) s in group A, (1.8{+-}0.2) s and (2.6{+-}0.2) s in group B] were statistically different (P< 0.01), but the BV[(12.0{+-}0.9) ml/100 g and (12.2{+-}1.0) ml/100 g in group A, (11.9{+-} 1.5) ml/100 g and (12.2{+-}1.3) ml/100 g in group B] were not different (P>0.05) between groups before ischemia and 4 h after ischemia. The BF, MTT and BV were not statistically significant between before ischemia and 4 h after reperfusion in group C and D (P>0.05). Conclusions: Edaravone can attenuate the degree of the PTE IRI. Multi-slice CT perfusion imaging can evaluate effect. (authors)}
journal = {Chinese Journal of Radiology}
issue = {10}
volume = {42}
place = {China}
year = {2008}
month = {Oct}
}