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Protective effect of Ocimum sanctum L after high-dose {sup 131}Iodine exposure in mice: an in vivo study

Journal Article:

Abstract

Radioprotective effect of aqueous extract of Ocimum sanctum (40 mg/kg body weight, for 15 days) in mice exposed to high-doses (3.7 MBq) of oral {sup 131}Iodine was investigated by studying the organ weights, lipid peroxidation and antioxidant defense enzymes in various target organs like liver, kidneys, salivary glands and stomach at 24 hr after exposure in adult Swiss mice. The mean weight of the salivary glands showed significant increase after {sup 131}Iodine administration. {sup 131}Iodine exposure significantly increased lipid peroxidation in kidneys and salivary glands in comparison to control animals. Pretreatment with O. sanctum in radioiodine exposed group showed significant reduction in lipid peroxidation in both kidneys and salivary glands. In liver, reduced glutathione (GSH) levels showed significant reduction after radioiodine exposure while pretreatment with O. sanctum exhibited less depletion in GSH level even after {sup 131}Iodine exposure. However, no such changes were observed in stomach. The results indicate the possibility of using aqueous extract of O. sanctum for ameliorating {sup 131}lodine induced damage to the salivary glands. (author)
Authors:
Bhartiya, Uma S; Raut, Yogita S; Joseph, Lebana J; [1]  Rao, Badanidiyoor S [2] 
  1. Laboratory Nuclear Medicine Section, Radiochemistry and Isotope Group, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Parel, Mumbai (India)
  2. Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai (India)
Publication Date:
Aug 15, 2006
Product Type:
Journal Article
Resource Relation:
Journal Name: Indian Journal of Experimental Biology; Journal Volume: 44; Journal Issue: 8; Other Information: 34 refs., 1 fig., 1 tab.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ANTIOXIDANTS; IODINE 131; MICE; RADIATION DOSES; RADIOPROTECTIVE SUBSTANCES; SALIVARY GLANDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DOSES; DRUGS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; VERTEBRATES
OSTI ID:
21393683
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: IJEBA6; TRN: IN1001508121122
Submitting Site:
INIS
Size:
page(s) 647-652
Announcement Date:
Feb 07, 2011

Journal Article:

Citation Formats

Bhartiya, Uma S, Raut, Yogita S, Joseph, Lebana J, and Rao, Badanidiyoor S. Protective effect of Ocimum sanctum L after high-dose {sup 131}Iodine exposure in mice: an in vivo study. India: N. p., 2006. Web.
Bhartiya, Uma S, Raut, Yogita S, Joseph, Lebana J, & Rao, Badanidiyoor S. Protective effect of Ocimum sanctum L after high-dose {sup 131}Iodine exposure in mice: an in vivo study. India.
Bhartiya, Uma S, Raut, Yogita S, Joseph, Lebana J, and Rao, Badanidiyoor S. 2006. "Protective effect of Ocimum sanctum L after high-dose {sup 131}Iodine exposure in mice: an in vivo study." India.
@misc{etde_21393683,
title = {Protective effect of Ocimum sanctum L after high-dose {sup 131}Iodine exposure in mice: an in vivo study}
author = {Bhartiya, Uma S, Raut, Yogita S, Joseph, Lebana J, and Rao, Badanidiyoor S}
abstractNote = {Radioprotective effect of aqueous extract of Ocimum sanctum (40 mg/kg body weight, for 15 days) in mice exposed to high-doses (3.7 MBq) of oral {sup 131}Iodine was investigated by studying the organ weights, lipid peroxidation and antioxidant defense enzymes in various target organs like liver, kidneys, salivary glands and stomach at 24 hr after exposure in adult Swiss mice. The mean weight of the salivary glands showed significant increase after {sup 131}Iodine administration. {sup 131}Iodine exposure significantly increased lipid peroxidation in kidneys and salivary glands in comparison to control animals. Pretreatment with O. sanctum in radioiodine exposed group showed significant reduction in lipid peroxidation in both kidneys and salivary glands. In liver, reduced glutathione (GSH) levels showed significant reduction after radioiodine exposure while pretreatment with O. sanctum exhibited less depletion in GSH level even after {sup 131}Iodine exposure. However, no such changes were observed in stomach. The results indicate the possibility of using aqueous extract of O. sanctum for ameliorating {sup 131}lodine induced damage to the salivary glands. (author)}
journal = {Indian Journal of Experimental Biology}
issue = {8}
volume = {44}
place = {India}
year = {2006}
month = {Aug}
}