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Naturally occurring antifungal aromatic esters and amides

Abstract

During the search of antifungal natural products from terrestrial plants, a new long chained aromatic ester named grandiflorate along with spatazoate from Portulaca grandiflora and N-[2-methoxy-2-(4-methoxyphenyl) ethyl]-trans-cinnamide and aegeline from Solanum erianthum of Nigeria were isolated and tested against six fungal species. The known constituents have not been reported so far from mentioned investigated plants. Structures of the isolated compounds were elucidated with the aid of spectroscopic techniques including two dimensional NMR experiments. Among the compounds, the esters found more potent than amides against Candida albicans and Aspergillus flavus. The new compound grandiflorate gave response against all tested fungal species while aegeline was found to give lowest inhibition during this study. (author)
Authors:
Ali, M S; Shahnaz,; Tabassum, S; Ogunwande, I A; Pervez, M K [1] 
  1. University of Karachi (Pakistan). HEJ Research Inst. of Chemistry, International Centre for Chemical and Biological Sciences
Publication Date:
Aug 15, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Chemical Society of Pakistan; Journal Volume: 32; Journal Issue: 4
Subject:
60 APPLIED LIFE SCIENCES; AMIDES; CANDIDA; ESTERS; FUNGI; SOLANUM; TERRESTRIAL ECOSYSTEMS; ECOSYSTEMS; EUMYCOTA; MAGNOLIOPHYTA; MAGNOLIOPSIDA; MICROORGANISMS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; YEASTS
OSTI ID:
21388508
Country of Origin:
Pakistan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0253-5106; TRN: PK1000615117167
Submitting Site:
INIS
Size:
page(s) 565-570
Announcement Date:
Jan 24, 2011

Citation Formats

Ali, M S, Shahnaz,, Tabassum, S, Ogunwande, I A, and Pervez, M K. Naturally occurring antifungal aromatic esters and amides. Pakistan: N. p., 2010. Web.
Ali, M S, Shahnaz,, Tabassum, S, Ogunwande, I A, & Pervez, M K. Naturally occurring antifungal aromatic esters and amides. Pakistan.
Ali, M S, Shahnaz,, Tabassum, S, Ogunwande, I A, and Pervez, M K. 2010. "Naturally occurring antifungal aromatic esters and amides." Pakistan.
@misc{etde_21388508,
title = {Naturally occurring antifungal aromatic esters and amides}
author = {Ali, M S, Shahnaz,, Tabassum, S, Ogunwande, I A, and Pervez, M K}
abstractNote = {During the search of antifungal natural products from terrestrial plants, a new long chained aromatic ester named grandiflorate along with spatazoate from Portulaca grandiflora and N-[2-methoxy-2-(4-methoxyphenyl) ethyl]-trans-cinnamide and aegeline from Solanum erianthum of Nigeria were isolated and tested against six fungal species. The known constituents have not been reported so far from mentioned investigated plants. Structures of the isolated compounds were elucidated with the aid of spectroscopic techniques including two dimensional NMR experiments. Among the compounds, the esters found more potent than amides against Candida albicans and Aspergillus flavus. The new compound grandiflorate gave response against all tested fungal species while aegeline was found to give lowest inhibition during this study. (author)}
journal = []
issue = {4}
volume = {32}
place = {Pakistan}
year = {2010}
month = {Aug}
}