You need JavaScript to view this

Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium

Journal Article:

Abstract

Metal complexes are famous for a wide array of chemotherapeutic effects. The current study was designed to synthesize and evaluate unexplored chemotherapeutic effects of Cu (II) and Nickel (II) complexes of the non-steroidal anti-inflammatory drug diclofenac. Nickel complex exhibited significant leishmanicidal activity against Lieshmania major, while the copper complex was found to possess low activity against the same pathogen. Both of the complexes revealed low antibacterial activities and were interestingly failed to produce any considerable antimalarial activity against Plasmodium falciparum 3D7. Selective leishmanicidal activities of Nickel (II) complex of diclofenac needs further improvement to be developed as potential new metal-based leishmanicidal agent.(author)
Authors:
Rehman, F U; Khan, M F; Khan, G M; Khan, H; [1]  Khan, I U [2] 
  1. Gomal University, D.I. Khan (Pakistan). Dept. of Faculty of Pharmacy
  2. University of Peshawar (Pakistan). Dept. of Faculty of Pharmacy
Publication Date:
Aug 15, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of the Chemical Society of Pakistan; Journal Volume: 32; Journal Issue: 4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIPYRETICS; CHEMOTHERAPY; COPPER COMPLEXES; COPPER IONS; MALARIA; NICKEL COMPLEXES; NICKEL IONS; PLASMODIUM; SODIUM COMPLEXES; STEROIDS; ALKALI METAL COMPLEXES; ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHARGED PARTICLES; COMPLEXES; DISEASES; DRUGS; INFECTIOUS DISEASES; INVERTEBRATES; IONS; MEDICINE; MICROORGANISMS; ORGANIC COMPOUNDS; PARASITES; PARASITIC DISEASES; PROTOZOA; SPOROZOA; THERAPY; TRANSITION ELEMENT COMPLEXES
OSTI ID:
21386446
Country of Origin:
Pakistan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0253-5106; TRN: PK1000600115051
Submitting Site:
INIS
Size:
page(s) 462-466
Announcement Date:
Jan 22, 2011

Journal Article:

Citation Formats

Rehman, F U, Khan, M F, Khan, G M, Khan, H, and Khan, I U. Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium. Pakistan: N. p., 2010. Web.
Rehman, F U, Khan, M F, Khan, G M, Khan, H, & Khan, I U. Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium. Pakistan.
Rehman, F U, Khan, M F, Khan, G M, Khan, H, and Khan, I U. 2010. "Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium." Pakistan.
@misc{etde_21386446,
title = {Antibacterial, antimalarial and leishmanicidal activities of Cu (II) and nickel (II) complexes of diclofenac sodium}
author = {Rehman, F U, Khan, M F, Khan, G M, Khan, H, and Khan, I U}
abstractNote = {Metal complexes are famous for a wide array of chemotherapeutic effects. The current study was designed to synthesize and evaluate unexplored chemotherapeutic effects of Cu (II) and Nickel (II) complexes of the non-steroidal anti-inflammatory drug diclofenac. Nickel complex exhibited significant leishmanicidal activity against Lieshmania major, while the copper complex was found to possess low activity against the same pathogen. Both of the complexes revealed low antibacterial activities and were interestingly failed to produce any considerable antimalarial activity against Plasmodium falciparum 3D7. Selective leishmanicidal activities of Nickel (II) complex of diclofenac needs further improvement to be developed as potential new metal-based leishmanicidal agent.(author)}
journal = {Journal of the Chemical Society of Pakistan}
issue = {4}
volume = {32}
place = {Pakistan}
year = {2010}
month = {Aug}
}