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An Experimental Study for Radiation Nephritis in Rabbits

Journal Article:

Abstract

Experimental radiation nephritis was produced in 15 rabbits by X-irradiation. About 2, 000gamma(tissue doses) were given to both kidneys of a rabbit in 5 days. Other tissues and organs except both kidneys were protected with 2 mm thickened lead plates. 5 weeks after the last irradiation, blood pictures, blood pressures, B.U.N., serum creatinine, Ca, Mg, Fe levels and serum erythropoietin activity of the irradiated rabbits were studied. After finishing above studies, rabbits were sacrificed and both kidneys were removed and examined histopathologically. Same laboratory and pathological studies were performed in 6 control rabbits. In this study, the author obtained following results. 1) Both kidneys of rabbits with experimental radiation nephritis showed marked histopathological changes, i.e.: renal tubules showed diffuse cloudy swelling, impacted intraluminal hyaline casts and focal precipitations of lime salts on the tubular epithelium. Diffuse interstitial fatty necrosis and various degrees of fibrotic infiltrations on the interstitium were also seen in association with focal lymphocytic infiltrations. Hyaline degenerations were observed on the glomeruli and small vessels. 2) Experimental radiation nephritis rabbits showed marked lowering in R.B.C. counts, decreased hemoglobin levels, low hematocrit values and leucopenia in comparison with those of control rabbits. (P<0.01). (Table 1 and 2). 3) Mild  More>>
Authors:
Kim, Myung Jae [1] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
Sep 15, 1972
Product Type:
Journal Article
Resource Relation:
Journal Name: Korean Journal of Nuclear Medicine; Journal Volume: 6; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; BLOOD SERUM; KIDNEYS; NEPHRITIS; PATHOLOGY; RABBITS; RADIATIONS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BLOOD VESSELS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; DISEASES; MAMMALS; MATERIALS; ORGANS; UROGENITAL SYSTEM DISEASES; VERTEBRATES
OSTI ID:
21376882
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1225-6714; TRN: KR1003404107336
Submitting Site:
KRN
Size:
page(s) 7-20
Announcement Date:
Dec 22, 2010

Journal Article:

Citation Formats

Kim, Myung Jae. An Experimental Study for Radiation Nephritis in Rabbits. Korea, Republic of: N. p., 1972. Web.
Kim, Myung Jae. An Experimental Study for Radiation Nephritis in Rabbits. Korea, Republic of.
Kim, Myung Jae. 1972. "An Experimental Study for Radiation Nephritis in Rabbits." Korea, Republic of.
@misc{etde_21376882,
title = {An Experimental Study for Radiation Nephritis in Rabbits}
author = {Kim, Myung Jae}
abstractNote = {Experimental radiation nephritis was produced in 15 rabbits by X-irradiation. About 2, 000gamma(tissue doses) were given to both kidneys of a rabbit in 5 days. Other tissues and organs except both kidneys were protected with 2 mm thickened lead plates. 5 weeks after the last irradiation, blood pictures, blood pressures, B.U.N., serum creatinine, Ca, Mg, Fe levels and serum erythropoietin activity of the irradiated rabbits were studied. After finishing above studies, rabbits were sacrificed and both kidneys were removed and examined histopathologically. Same laboratory and pathological studies were performed in 6 control rabbits. In this study, the author obtained following results. 1) Both kidneys of rabbits with experimental radiation nephritis showed marked histopathological changes, i.e.: renal tubules showed diffuse cloudy swelling, impacted intraluminal hyaline casts and focal precipitations of lime salts on the tubular epithelium. Diffuse interstitial fatty necrosis and various degrees of fibrotic infiltrations on the interstitium were also seen in association with focal lymphocytic infiltrations. Hyaline degenerations were observed on the glomeruli and small vessels. 2) Experimental radiation nephritis rabbits showed marked lowering in R.B.C. counts, decreased hemoglobin levels, low hematocrit values and leucopenia in comparison with those of control rabbits. (P<0.01). (Table 1 and 2). 3) Mild proteinuria were observed in experimental radiation nephritis in rabbits. 4) The levels of B.U.N. and serum creatinine increased in experimental radiation nephritis. (P<0.01). (Table 1, 3 and 4). 5) The levels of serum Ca and Mg Showed no statistical difference in comparison with those of control rabbits. (P>0.05). (Table 3 and 4). 6) No statistical correlations were observable between the levels of B.U.N. and Hb. values. (gamma=-0. 223). No close correlations (gamma=-0.338) were noticed between the levels of B.U.N. and serum iron levels. 7) Erythropoietin activity (R.B.C. {sup 59}Fe Incorporation) was measured by the modified Fried method. No change in its activity was noticed in radiation nephritis group comparing with that of the control group. (P>0.05). (Table 1, 3 and 5). 8) Carotid artery blood pressures showed also no difference. (P>0.05). (Table 1 and 2).}
journal = {Korean Journal of Nuclear Medicine}
issue = {2}
volume = {6}
place = {Korea, Republic of}
year = {1972}
month = {Sep}
}