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Plasma Renin Activity in Diabetes Mellitus

Journal Article:

Abstract

To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity (PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the presence of nephropathy and/or hypertension. Uncomplicated diabetics (Group I) were taken as control group and the results of the other groups were compared to this group. In diabetics with nephropathy alone (Group II), and with nephropathy and hypertension (Group III), basal PRA values were 0.63+-0.59 ng/ml/hr., and 0.79+-0.62 ng/ml/hr., respectively, both significantly lower than control group. (1.53+-1.09 ng/ml/hr.). (p<0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics, with hypertension only (Group IV), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes mellitus
Authors:
Pyo, Heui Jung; Sik, Park Jung; Kim, Sung Kwon; Choi, Kang Won; Lee, Jung Sang; Lee, Mun Ho [1] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
Mar 15, 1979
Product Type:
Journal Article
Resource Relation:
Journal Name: Korean Journal of Nuclear Medicine; Journal Volume: 13; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALDOSTERONE; ANGIOTENSIN; DIABETES MELLITUS; PLASMA; RENIN; ADRENAL HORMONES; ALDEHYDES; CARDIOVASCULAR AGENTS; CORTICOSTEROIDS; DISEASES; DRUGS; ENDOCRINE DISEASES; ENZYMES; GLOBULINS; HORMONES; HYDROLASES; HYDROXY COMPOUNDS; KETONES; METABOLIC DISEASES; MINERALOCORTICOIDS; NONSPECIFIC PEPTIDASES; ORGANIC COMPOUNDS; PEPTIDE HYDROLASES; PREGNANES; PROTEINS; STEROID HORMONES; STEROIDS; VASOCONSTRICTORS
OSTI ID:
21376853
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1225-6714; TRN: KR1003339107307
Submitting Site:
KRN
Size:
page(s) 23-29
Announcement Date:
Dec 22, 2010

Journal Article:

Citation Formats

Pyo, Heui Jung, Sik, Park Jung, Kim, Sung Kwon, Choi, Kang Won, Lee, Jung Sang, and Lee, Mun Ho. Plasma Renin Activity in Diabetes Mellitus. Korea, Republic of: N. p., 1979. Web.
Pyo, Heui Jung, Sik, Park Jung, Kim, Sung Kwon, Choi, Kang Won, Lee, Jung Sang, & Lee, Mun Ho. Plasma Renin Activity in Diabetes Mellitus. Korea, Republic of.
Pyo, Heui Jung, Sik, Park Jung, Kim, Sung Kwon, Choi, Kang Won, Lee, Jung Sang, and Lee, Mun Ho. 1979. "Plasma Renin Activity in Diabetes Mellitus." Korea, Republic of.
@misc{etde_21376853,
title = {Plasma Renin Activity in Diabetes Mellitus}
author = {Pyo, Heui Jung, Sik, Park Jung, Kim, Sung Kwon, Choi, Kang Won, Lee, Jung Sang, and Lee, Mun Ho}
abstractNote = {To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity (PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the presence of nephropathy and/or hypertension. Uncomplicated diabetics (Group I) were taken as control group and the results of the other groups were compared to this group. In diabetics with nephropathy alone (Group II), and with nephropathy and hypertension (Group III), basal PRA values were 0.63+-0.59 ng/ml/hr., and 0.79+-0.62 ng/ml/hr., respectively, both significantly lower than control group. (1.53+-1.09 ng/ml/hr.). (p<0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics, with hypertension only (Group IV), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes mellitus}
journal = {Korean Journal of Nuclear Medicine}
issue = {1}
volume = {13}
place = {Korea, Republic of}
year = {1979}
month = {Mar}
}