You need JavaScript to view this

Study on the Diurnal Variation of the Plasma Immunoreactive Glucagon

Journal Article:

Abstract

It is well known that glucagon, like insulin, is very important in the moment-to-moment control of the homeostasis of glucose, and of amino acids. Glucagon has been shown to have potent glycogenolytic, gluconeogenic and lipolytic activities. Attention to its role in the pathogenesis of diabetes mellitus and hypoglycemia has been also advanced recently. To evaluate the diurnal variation of plasma glucagon concentration, we measured serum glucose, insulin, and plasma glucagon every 30 minutes or every hour in 7 normal Korean adults. Results were as follows: 1) Although plasma glucagon concentration showed wide individual variations, it had a tendency to decrease after meals. After lunch and dinner, plasma glucagon concentration had gradually declined and reached its nadir at postprandial 2-2.5 hours. The minimal level of plasma glucagon was at 4 A.M. 2) Serum insulin:plasma glucagon ratios were increased promptly after meals. Especially after lunch, its peak was prominent (3.65 +- 1. 95). The minimal level of serum insulin:plasma glucagon ratio appeared at 6 A.M.
Authors:
Lee, Hong Kyu; Hong, Kee Suk; Kim, Byoung Kook; Koh, Chang Soon; [1]  Chung, June Key; Kim, Eui Chong [2] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
  2. Seoul District Armed Forces General Hospital, Seoul (Korea, Republic of)
Publication Date:
Mar 15, 1984
Product Type:
Journal Article
Resource Relation:
Journal Name: Korean Journal of Nuclear Medicine; Journal Volume: 18; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD SERUM; DIABETES MELLITUS; GLUCAGON; INSULIN; PATHOGENESIS; PLASMA; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; DISEASES; ENDOCRINE DISEASES; HORMONES; MATERIALS; METABOLIC DISEASES; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS
OSTI ID:
21376842
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1225-6714; TRN: KR1003216107296
Submitting Site:
KRN
Size:
page(s) 39-44
Announcement Date:
Dec 22, 2010

Journal Article:

Citation Formats

Lee, Hong Kyu, Hong, Kee Suk, Kim, Byoung Kook, Koh, Chang Soon, Chung, June Key, and Kim, Eui Chong. Study on the Diurnal Variation of the Plasma Immunoreactive Glucagon. Korea, Republic of: N. p., 1984. Web.
Lee, Hong Kyu, Hong, Kee Suk, Kim, Byoung Kook, Koh, Chang Soon, Chung, June Key, & Kim, Eui Chong. Study on the Diurnal Variation of the Plasma Immunoreactive Glucagon. Korea, Republic of.
Lee, Hong Kyu, Hong, Kee Suk, Kim, Byoung Kook, Koh, Chang Soon, Chung, June Key, and Kim, Eui Chong. 1984. "Study on the Diurnal Variation of the Plasma Immunoreactive Glucagon." Korea, Republic of.
@misc{etde_21376842,
title = {Study on the Diurnal Variation of the Plasma Immunoreactive Glucagon}
author = {Lee, Hong Kyu, Hong, Kee Suk, Kim, Byoung Kook, Koh, Chang Soon, Chung, June Key, and Kim, Eui Chong}
abstractNote = {It is well known that glucagon, like insulin, is very important in the moment-to-moment control of the homeostasis of glucose, and of amino acids. Glucagon has been shown to have potent glycogenolytic, gluconeogenic and lipolytic activities. Attention to its role in the pathogenesis of diabetes mellitus and hypoglycemia has been also advanced recently. To evaluate the diurnal variation of plasma glucagon concentration, we measured serum glucose, insulin, and plasma glucagon every 30 minutes or every hour in 7 normal Korean adults. Results were as follows: 1) Although plasma glucagon concentration showed wide individual variations, it had a tendency to decrease after meals. After lunch and dinner, plasma glucagon concentration had gradually declined and reached its nadir at postprandial 2-2.5 hours. The minimal level of plasma glucagon was at 4 A.M. 2) Serum insulin:plasma glucagon ratios were increased promptly after meals. Especially after lunch, its peak was prominent (3.65 +- 1. 95). The minimal level of serum insulin:plasma glucagon ratio appeared at 6 A.M.}
journal = {Korean Journal of Nuclear Medicine}
issue = {1}
volume = {18}
place = {Korea, Republic of}
year = {1984}
month = {Mar}
}