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Anemia of Chronic Liver Diseases

Journal Article:

Abstract

The pathogenetic mechanisms of anemia in patients with chronic liver disease were observed. Seventeen patients with moderate to advanced hepatic diseases were studied by various methods. Only patients without previous blood loss were included : 14 had cirrhosis, 2 had active chronic hepatitis, and one had inferior vena cava obstruction with associated liver cirrhosis. The followings were the results: 1. The anemia based on red blood cell count, Hb., and Ht. was found in 76.5-78.6% of the patients. 2. Red cell indices indicated that normo-macrocytic and normochromic anemia was present is the majority of the patients. 3. No evidence of megaloblastic anemia was found on the basis of the morphological examinations. 4. Serum iron, TIBC, % saturation and iron content in the bone marrow indicated that iron deficiency anemia was present in about half of the patients. 5. In the view of the erythrocyte dynamics, primary increase in the red cell destruction was ascribed to the cause of the anemia. 6. Decrease in the red cell survival time was not correlated with MCV, % saturation and S.L. ratio. Also, hemoglobin level was not correlated with MCV, % saturation and T{sub 50} Cr. Therefore, multiple causes may be involved in the  More>>
Authors:
Shin, Hyun Chung; Lee, Jhung Sang; Koh, Chang Soon; Lee, Mun Ho [1] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
Sep 15, 1971
Product Type:
Journal Article
Resource Relation:
Journal Name: Korean Journal of Nuclear Medicine; Journal Volume: 5; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANEMIAS; BLOOD; LIVER; LIVER CIRRHOSIS; PATHOGENESIS; PATIENTS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASES; GLANDS; HEMIC DISEASES; MATERIALS; ORGANS; SYMPTOMS
OSTI ID:
21374451
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1225-6714; TRN: KR1003417104905
Submitting Site:
KRN
Size:
page(s) 41-56
Announcement Date:
Dec 30, 2010

Journal Article:

Citation Formats

Shin, Hyun Chung, Lee, Jhung Sang, Koh, Chang Soon, and Lee, Mun Ho. Anemia of Chronic Liver Diseases. Korea, Republic of: N. p., 1971. Web.
Shin, Hyun Chung, Lee, Jhung Sang, Koh, Chang Soon, & Lee, Mun Ho. Anemia of Chronic Liver Diseases. Korea, Republic of.
Shin, Hyun Chung, Lee, Jhung Sang, Koh, Chang Soon, and Lee, Mun Ho. 1971. "Anemia of Chronic Liver Diseases." Korea, Republic of.
@misc{etde_21374451,
title = {Anemia of Chronic Liver Diseases}
author = {Shin, Hyun Chung, Lee, Jhung Sang, Koh, Chang Soon, and Lee, Mun Ho}
abstractNote = {The pathogenetic mechanisms of anemia in patients with chronic liver disease were observed. Seventeen patients with moderate to advanced hepatic diseases were studied by various methods. Only patients without previous blood loss were included : 14 had cirrhosis, 2 had active chronic hepatitis, and one had inferior vena cava obstruction with associated liver cirrhosis. The followings were the results: 1. The anemia based on red blood cell count, Hb., and Ht. was found in 76.5-78.6% of the patients. 2. Red cell indices indicated that normo-macrocytic and normochromic anemia was present is the majority of the patients. 3. No evidence of megaloblastic anemia was found on the basis of the morphological examinations. 4. Serum iron, TIBC, % saturation and iron content in the bone marrow indicated that iron deficiency anemia was present in about half of the patients. 5. In the view of the erythrocyte dynamics, primary increase in the red cell destruction was ascribed to the cause of the anemia. 6. Decrease in the red cell survival time was not correlated with MCV, % saturation and S.L. ratio. Also, hemoglobin level was not correlated with MCV, % saturation and T{sub 50} Cr. Therefore, multiple causes may be involved in the pathogenesis of the anemia. 7. Anemia as determined by the red cell volume was found in only 60% of the patients. It may be possible that hemodilutional anemia is present.}
journal = {Korean Journal of Nuclear Medicine}
issue = {2}
volume = {5}
place = {Korea, Republic of}
year = {1971}
month = {Sep}
}