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A Study on the Glucose and Immunoreactive Insulin Response during Oral Glucose Tolerance Test in Patients with Chronic Liver Diseases

Journal Article:

Abstract

The blood glucose and plasma immunoreactive insulin (IRI) levels were measured during aral glucose tolerance test in 7 healthy subjects and 6 patients with chronic liver diseases. The glucose tolerance was impaired in 5 of the 6 patients and normal in I. Plasma IRI responses were markedly increased and delayed in all patients, suggesting endogenous insulin resistance. Patients with more glucose intolerance showed less increase in plasma IRI than the group with less intolerance. lt is suggested that some insulin antagonists may decrease the peripheral insulin sensitivity and stimulate compensatory hyperactivity of pancreatic islets. If the compensatory hyperactivity is inadequate due to gemetic predisposition to diabetes mellitus or exhaustion of beta-cells of pancreatic islets, the glucose intolerance and overt diabetes mellitus may ensue.
Authors:
Choe, Kang Won; Lee, Hong Kyu; Koh, Chang Soon; Lee, Mu Ho [1] 
  1. Seoul National University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
Mar 15, 1973
Product Type:
Journal Article
Resource Relation:
Journal Name: Korean Journal of Nuclear Medicine; Journal Volume: 7; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIABETES MELLITUS; GLUCOSE; INSULIN; LIVER; PANCREAS; PATIENTS; ALDEHYDES; BODY; CARBOHYDRATES; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; HEXOSES; HORMONES; METABOLIC DISEASES; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PROTEINS; SACCHARIDES
OSTI ID:
21374432
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1225-6714; TRN: KR1003390104886
Submitting Site:
KRN
Size:
page(s) 31-38
Announcement Date:
Dec 30, 2010

Journal Article:

Citation Formats

Choe, Kang Won, Lee, Hong Kyu, Koh, Chang Soon, and Lee, Mu Ho. A Study on the Glucose and Immunoreactive Insulin Response during Oral Glucose Tolerance Test in Patients with Chronic Liver Diseases. Korea, Republic of: N. p., 1973. Web.
Choe, Kang Won, Lee, Hong Kyu, Koh, Chang Soon, & Lee, Mu Ho. A Study on the Glucose and Immunoreactive Insulin Response during Oral Glucose Tolerance Test in Patients with Chronic Liver Diseases. Korea, Republic of.
Choe, Kang Won, Lee, Hong Kyu, Koh, Chang Soon, and Lee, Mu Ho. 1973. "A Study on the Glucose and Immunoreactive Insulin Response during Oral Glucose Tolerance Test in Patients with Chronic Liver Diseases." Korea, Republic of.
@misc{etde_21374432,
title = {A Study on the Glucose and Immunoreactive Insulin Response during Oral Glucose Tolerance Test in Patients with Chronic Liver Diseases}
author = {Choe, Kang Won, Lee, Hong Kyu, Koh, Chang Soon, and Lee, Mu Ho}
abstractNote = {The blood glucose and plasma immunoreactive insulin (IRI) levels were measured during aral glucose tolerance test in 7 healthy subjects and 6 patients with chronic liver diseases. The glucose tolerance was impaired in 5 of the 6 patients and normal in I. Plasma IRI responses were markedly increased and delayed in all patients, suggesting endogenous insulin resistance. Patients with more glucose intolerance showed less increase in plasma IRI than the group with less intolerance. lt is suggested that some insulin antagonists may decrease the peripheral insulin sensitivity and stimulate compensatory hyperactivity of pancreatic islets. If the compensatory hyperactivity is inadequate due to gemetic predisposition to diabetes mellitus or exhaustion of beta-cells of pancreatic islets, the glucose intolerance and overt diabetes mellitus may ensue.}
journal = {Korean Journal of Nuclear Medicine}
issue = {1}
volume = {7}
place = {Korea, Republic of}
year = {1973}
month = {Mar}
}