You need JavaScript to view this

The Clinical Significance of Serum Beta{sub 2}-microglobulin Levels in Patients with Various Liver Diseases

Journal Article:

Abstract

To evaluate the significance of serum beta{sub 2}-microglobulin in patients with various liver diseases, serum {sub 2} m levels were measured in 44 cases of normal controls, 32 cases of asymptomatic HBsAg carriers and 134 patients with various liver diseases, by radioimmunoassay using Phadebas Beta{sub 2}-micro test kits. The following results were obtained: I) The mean level of serum beta{sub 2} m was 1 39+-0.25 mg/l(Mean+-S.D.) in normal controls (1.39+-0.23 mg/l in 24 males, 1.38+-0,27 mg/l in 20 females). 2) The serum levels of beta{sub 2} in patients with various liver diseases and asymptomatic HBsAg carriers were as follows; 1.40+-0.27 mg/l in asymptomatic HBsAg carriers, 2.42+-0.377 mg/l in 45 patients with acute viral hepatitis, 2.10+-0.26 mg/l in 46 patients with chronic persistent hepatitis, 2.60+-0.34 mg/l in 23 patients with chronic active hepatitis, and 2.60+-0.49 mg/l in 20 patients with liver cirrhosis. Serum beta{sub 2}m levels of each disease group were significantly higher than that of normal controls(p<0.001). 3) There was significant correlation between the levels of serum beta{sub 2}m and the degrees of lymphocytic infiltration in patients with chronic active hepatitis(p<0.001). 4) Significant correlations were observed between the levels of serum beta{sub 2}-microglobulin and serum alanine aminotransferase(r=0.68, p<0.05) and bilirubin(r=0.63,  More>>
Authors:
Chang, Suk Won; Cho, Tae Bong; Choe, Jung Ho; Kim, So Yon; Cho, Min Koo; Lee, Gwon Jun [1] 
  1. National Police Hospital, Seoul (Korea, Republic of)
Publication Date:
Sep 15, 1985
Product Type:
Journal Article
Resource Relation:
Journal Name: Korean Journal of Nuclear Medicine; Journal Volume: 19; Journal Issue: 2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD SERUM; GLOBULINS; LIVER; PATIENTS; RADIOIMMUNOASSAY; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; GLANDS; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; TRACER TECHNIQUES
OSTI ID:
21370208
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Journal ID: ISSN 1225-6714; TRN: KR1003207100662
Submitting Site:
KRN
Size:
page(s) 81-86
Announcement Date:
Dec 22, 2010

Journal Article:

Citation Formats

Chang, Suk Won, Cho, Tae Bong, Choe, Jung Ho, Kim, So Yon, Cho, Min Koo, and Lee, Gwon Jun. The Clinical Significance of Serum Beta{sub 2}-microglobulin Levels in Patients with Various Liver Diseases. Korea, Republic of: N. p., 1985. Web.
Chang, Suk Won, Cho, Tae Bong, Choe, Jung Ho, Kim, So Yon, Cho, Min Koo, & Lee, Gwon Jun. The Clinical Significance of Serum Beta{sub 2}-microglobulin Levels in Patients with Various Liver Diseases. Korea, Republic of.
Chang, Suk Won, Cho, Tae Bong, Choe, Jung Ho, Kim, So Yon, Cho, Min Koo, and Lee, Gwon Jun. 1985. "The Clinical Significance of Serum Beta{sub 2}-microglobulin Levels in Patients with Various Liver Diseases." Korea, Republic of.
@misc{etde_21370208,
title = {The Clinical Significance of Serum Beta{sub 2}-microglobulin Levels in Patients with Various Liver Diseases}
author = {Chang, Suk Won, Cho, Tae Bong, Choe, Jung Ho, Kim, So Yon, Cho, Min Koo, and Lee, Gwon Jun}
abstractNote = {To evaluate the significance of serum beta{sub 2}-microglobulin in patients with various liver diseases, serum {sub 2} m levels were measured in 44 cases of normal controls, 32 cases of asymptomatic HBsAg carriers and 134 patients with various liver diseases, by radioimmunoassay using Phadebas Beta{sub 2}-micro test kits. The following results were obtained: I) The mean level of serum beta{sub 2} m was 1 39+-0.25 mg/l(Mean+-S.D.) in normal controls (1.39+-0.23 mg/l in 24 males, 1.38+-0,27 mg/l in 20 females). 2) The serum levels of beta{sub 2} in patients with various liver diseases and asymptomatic HBsAg carriers were as follows; 1.40+-0.27 mg/l in asymptomatic HBsAg carriers, 2.42+-0.377 mg/l in 45 patients with acute viral hepatitis, 2.10+-0.26 mg/l in 46 patients with chronic persistent hepatitis, 2.60+-0.34 mg/l in 23 patients with chronic active hepatitis, and 2.60+-0.49 mg/l in 20 patients with liver cirrhosis. Serum beta{sub 2}m levels of each disease group were significantly higher than that of normal controls(p<0.001). 3) There was significant correlation between the levels of serum beta{sub 2}m and the degrees of lymphocytic infiltration in patients with chronic active hepatitis(p<0.001). 4) Significant correlations were observed between the levels of serum beta{sub 2}-microglobulin and serum alanine aminotransferase(r=0.68, p<0.05) and bilirubin(r=0.63, p<0.05) in 15 patients with acute viral hepatitis. In conclusion, the serum beta{sub 2}-microglobulin levels were increased in patients with various liver diseases, and it may serve as a new index of liver disease activity.}
journal = {Korean Journal of Nuclear Medicine}
issue = {2}
volume = {19}
place = {Korea, Republic of}
year = {1985}
month = {Sep}
}