Abstract
Purpose: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R{sub 1}). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. Methods and materials: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R{sub 1} while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced DELTAR{sub 1}. Results: DELTAR{sub 1} showed significant increases of 0.021 to 0.058 s{sup -1} in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the DELTAR{sub 1} curve (consistent with minimal increase in oxygen concentration). Conclusions: These results provide
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O'Connor, James P.B.;
[1]
Naish, Josephine H;
Parker, Geoff J.M.;
[2]
Waterton, John C;
[2]
AstraZeneca, Cheshire;
[3]
Watson, Yvonne;
[2]
Jayson, Gordon C;
[4]
Buonaccorsi, Giovanni A;
Cheung, Sue;
Buckley, David L;
McGrath, Deirdre M;
[2]
West, Catharine M.L.;
[5]
Davidson, Susan E;
[6]
Roberts, Caleb;
Mills, Samantha J;
[2]
Mitchell, Claire L;
Hope, Lynn;
Ton, N Chan;
[4]
Jackson, Alan
[2]
- Imaging Science and Biomedical Engineering, University of Manchester, Manchester (United Kingdom) and Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester (United Kingdom)
- Imaging Science and Biomedical Engineering, University of Manchester, Manchester (United Kingdom)
- United Kingdom
- Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester (United Kingdom)
- Academic Department of Radiation Oncology, University of Manchester, Manchester (United Kingdom)
- Department of Clinical Oncology, Christie Hospital, Manchester (United Kingdom)
Citation Formats
O'Connor, James P.B., Naish, Josephine H, Parker, Geoff J.M., Waterton, John C, AstraZeneca, Cheshire, Watson, Yvonne, Jayson, Gordon C, Buonaccorsi, Giovanni A, Cheung, Sue, Buckley, David L, McGrath, Deirdre M, West, Catharine M.L., Davidson, Susan E, Roberts, Caleb, Mills, Samantha J, Mitchell, Claire L, Hope, Lynn, Ton, N Chan, and Jackson, Alan.
Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors.
United States: N. p.,
2009.
Web.
doi:10.1016/j.ijrobp.2008.12.040.
O'Connor, James P.B., Naish, Josephine H, Parker, Geoff J.M., Waterton, John C, AstraZeneca, Cheshire, Watson, Yvonne, Jayson, Gordon C, Buonaccorsi, Giovanni A, Cheung, Sue, Buckley, David L, McGrath, Deirdre M, West, Catharine M.L., Davidson, Susan E, Roberts, Caleb, Mills, Samantha J, Mitchell, Claire L, Hope, Lynn, Ton, N Chan, & Jackson, Alan.
Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors.
United States.
https://doi.org/10.1016/j.ijrobp.2008.12.040
O'Connor, James P.B., Naish, Josephine H, Parker, Geoff J.M., Waterton, John C, AstraZeneca, Cheshire, Watson, Yvonne, Jayson, Gordon C, Buonaccorsi, Giovanni A, Cheung, Sue, Buckley, David L, McGrath, Deirdre M, West, Catharine M.L., Davidson, Susan E, Roberts, Caleb, Mills, Samantha J, Mitchell, Claire L, Hope, Lynn, Ton, N Chan, and Jackson, Alan.
2009.
"Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors."
United States.
https://doi.org/10.1016/j.ijrobp.2008.12.040.
@misc{etde_21367523,
title = {Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors}
author = {O'Connor, James P.B., Naish, Josephine H, Parker, Geoff J.M., Waterton, John C, AstraZeneca, Cheshire, Watson, Yvonne, Jayson, Gordon C, Buonaccorsi, Giovanni A, Cheung, Sue, Buckley, David L, McGrath, Deirdre M, West, Catharine M.L., Davidson, Susan E, Roberts, Caleb, Mills, Samantha J, Mitchell, Claire L, Hope, Lynn, Ton, N Chan, and Jackson, Alan}
abstractNote = {Purpose: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R{sub 1}). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. Methods and materials: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R{sub 1} while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced DELTAR{sub 1}. Results: DELTAR{sub 1} showed significant increases of 0.021 to 0.058 s{sup -1} in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the DELTAR{sub 1} curve (consistent with minimal increase in oxygen concentration). Conclusions: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration.}
doi = {10.1016/j.ijrobp.2008.12.040}
journal = []
issue = {4}
volume = {75}
place = {United States}
year = {2009}
month = {Nov}
}
title = {Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors}
author = {O'Connor, James P.B., Naish, Josephine H, Parker, Geoff J.M., Waterton, John C, AstraZeneca, Cheshire, Watson, Yvonne, Jayson, Gordon C, Buonaccorsi, Giovanni A, Cheung, Sue, Buckley, David L, McGrath, Deirdre M, West, Catharine M.L., Davidson, Susan E, Roberts, Caleb, Mills, Samantha J, Mitchell, Claire L, Hope, Lynn, Ton, N Chan, and Jackson, Alan}
abstractNote = {Purpose: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R{sub 1}). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. Methods and materials: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R{sub 1} while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced DELTAR{sub 1}. Results: DELTAR{sub 1} showed significant increases of 0.021 to 0.058 s{sup -1} in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the DELTAR{sub 1} curve (consistent with minimal increase in oxygen concentration). Conclusions: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration.}
doi = {10.1016/j.ijrobp.2008.12.040}
journal = []
issue = {4}
volume = {75}
place = {United States}
year = {2009}
month = {Nov}
}