Abstract
Purpose: Evaluation of the results of perioperative interstitial brachytherapy with low dose-rate (L.D.R.) Ir-192 in the treatment of keloid scars. Patients and methods: We performed a retrospective analysis of 73 histologically confirmed keloids (from 58 patients) resistant to medico surgical treated by surgical excision plus early perioperative brachytherapy. All lesions were initially symptomatic. Local control was evaluated by clinical evaluation. Functional and cosmetic results were assessed in terms of patient responses to a self-administered questionnaire. Results: Median age was 28 years (range 13-71 years). Scars were located as follows: 37% on the face, 32% on the trunk or abdomen, 16% on the neck, and 15% on the arms or legs. The mean delay before loading was four hours (range, 1-6 h). The median dose was 20 Gy (range, 15-40 Gy). Sixty-four scars (from 53 patients) were evaluated. Local control was 86% (follow-up, 44.5 months; range, 14-150 months). All relapses occurred early within 2 years posttreatment. At 20 months, survival without recurrence was significantly lower when treated lengths were more than 6 cm long. The rate was 100% for treated scars below 4.5 cm in length, 95% (95% CI: 55-96) for those 4.5-6 cm long, and 75% (95% CI: 56-88) beyond
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Rio, E;
Bardet, E;
Peuvrel, P;
[1]
Martinet, L;
Perrot, P;
[2]
Baraer, F;
Loirat, Y;
[3]
Sartre, J Y;
[4]
Malard, O;
Ferron, C;
[5]
Dreno, B
[6]
- CRLCC Nantes-Atlantique, Service de radiotherapie, 44 - Nantes-St-Herblain (France)
- CHU Hotel-Dieu, Service de chirurgie plastique, 44 - Nantes (France)
- Clinique Breteche, Service de chirurgie plastique, 44 - Nantes (France)
- Clinique Jules-Verne, Service de chirurgie plastique, 44 - Nantes (France)
- CHU Hotel-Dieu, Service de Chirurgie ORL, 44 - Nantes (France)
- CHU Hotel-Dieu, Service de dermatologie, 44 - Nantes (France)
Citation Formats
Rio, E, Bardet, E, Peuvrel, P, Martinet, L, Perrot, P, Baraer, F, Loirat, Y, Sartre, J Y, Malard, O, Ferron, C, and Dreno, B.
Perioperative interstitial brachytherapy for recurrent keloid scars; La curietherapie interstitielle perioperatoire dans le traitement des cicatrices cheloides recidivantes.
France: N. p.,
2010.
Web.
doi:10.1016/J.CANRAD.2009.05.008.
Rio, E, Bardet, E, Peuvrel, P, Martinet, L, Perrot, P, Baraer, F, Loirat, Y, Sartre, J Y, Malard, O, Ferron, C, & Dreno, B.
Perioperative interstitial brachytherapy for recurrent keloid scars; La curietherapie interstitielle perioperatoire dans le traitement des cicatrices cheloides recidivantes.
France.
https://doi.org/10.1016/J.CANRAD.2009.05.008
Rio, E, Bardet, E, Peuvrel, P, Martinet, L, Perrot, P, Baraer, F, Loirat, Y, Sartre, J Y, Malard, O, Ferron, C, and Dreno, B.
2010.
"Perioperative interstitial brachytherapy for recurrent keloid scars; La curietherapie interstitielle perioperatoire dans le traitement des cicatrices cheloides recidivantes."
France.
https://doi.org/10.1016/J.CANRAD.2009.05.008.
@misc{etde_21362729,
title = {Perioperative interstitial brachytherapy for recurrent keloid scars; La curietherapie interstitielle perioperatoire dans le traitement des cicatrices cheloides recidivantes}
author = {Rio, E, Bardet, E, Peuvrel, P, Martinet, L, Perrot, P, Baraer, F, Loirat, Y, Sartre, J Y, Malard, O, Ferron, C, and Dreno, B}
abstractNote = {Purpose: Evaluation of the results of perioperative interstitial brachytherapy with low dose-rate (L.D.R.) Ir-192 in the treatment of keloid scars. Patients and methods: We performed a retrospective analysis of 73 histologically confirmed keloids (from 58 patients) resistant to medico surgical treated by surgical excision plus early perioperative brachytherapy. All lesions were initially symptomatic. Local control was evaluated by clinical evaluation. Functional and cosmetic results were assessed in terms of patient responses to a self-administered questionnaire. Results: Median age was 28 years (range 13-71 years). Scars were located as follows: 37% on the face, 32% on the trunk or abdomen, 16% on the neck, and 15% on the arms or legs. The mean delay before loading was four hours (range, 1-6 h). The median dose was 20 Gy (range, 15-40 Gy). Sixty-four scars (from 53 patients) were evaluated. Local control was 86% (follow-up, 44.5 months; range, 14-150 months). All relapses occurred early within 2 years posttreatment. At 20 months, survival without recurrence was significantly lower when treated lengths were more than 6 cm long. The rate was 100% for treated scars below 4.5 cm in length, 95% (95% CI: 55-96) for those 4.5-6 cm long, and 75% (95% CI: 56-88) beyond 6 cm (p = 0.038). Of the 35 scars (28 patients) whose results were reassessed, six remained symptomatic and the esthetic results were considered to be good in 51% (18/35) and average in 37% (13/35) (median follow-up, 70 months; range, 16-181 months). Conclusion: Early perioperative L.D.R. brachytherapy delivering 20 Gy at 5 mm reduced the rate of recurrent keloids resistant to other treatments and gave good functional results. (authors)}
doi = {10.1016/J.CANRAD.2009.05.008}
journal = []
issue = {no.1}
volume = {14}
place = {France}
year = {2010}
month = {Jan}
}
title = {Perioperative interstitial brachytherapy for recurrent keloid scars; La curietherapie interstitielle perioperatoire dans le traitement des cicatrices cheloides recidivantes}
author = {Rio, E, Bardet, E, Peuvrel, P, Martinet, L, Perrot, P, Baraer, F, Loirat, Y, Sartre, J Y, Malard, O, Ferron, C, and Dreno, B}
abstractNote = {Purpose: Evaluation of the results of perioperative interstitial brachytherapy with low dose-rate (L.D.R.) Ir-192 in the treatment of keloid scars. Patients and methods: We performed a retrospective analysis of 73 histologically confirmed keloids (from 58 patients) resistant to medico surgical treated by surgical excision plus early perioperative brachytherapy. All lesions were initially symptomatic. Local control was evaluated by clinical evaluation. Functional and cosmetic results were assessed in terms of patient responses to a self-administered questionnaire. Results: Median age was 28 years (range 13-71 years). Scars were located as follows: 37% on the face, 32% on the trunk or abdomen, 16% on the neck, and 15% on the arms or legs. The mean delay before loading was four hours (range, 1-6 h). The median dose was 20 Gy (range, 15-40 Gy). Sixty-four scars (from 53 patients) were evaluated. Local control was 86% (follow-up, 44.5 months; range, 14-150 months). All relapses occurred early within 2 years posttreatment. At 20 months, survival without recurrence was significantly lower when treated lengths were more than 6 cm long. The rate was 100% for treated scars below 4.5 cm in length, 95% (95% CI: 55-96) for those 4.5-6 cm long, and 75% (95% CI: 56-88) beyond 6 cm (p = 0.038). Of the 35 scars (28 patients) whose results were reassessed, six remained symptomatic and the esthetic results were considered to be good in 51% (18/35) and average in 37% (13/35) (median follow-up, 70 months; range, 16-181 months). Conclusion: Early perioperative L.D.R. brachytherapy delivering 20 Gy at 5 mm reduced the rate of recurrent keloids resistant to other treatments and gave good functional results. (authors)}
doi = {10.1016/J.CANRAD.2009.05.008}
journal = []
issue = {no.1}
volume = {14}
place = {France}
year = {2010}
month = {Jan}
}