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Prevalence of positive gated myocardial SPECT in diabetic and non-diabetic women and impact of other factors; KIHD perspective

Journal Article:

Abstract

The objective of the present study was to assess the prevalence of coronary artery disease (CAD) among diabetic (DM) and nondiabetic (NDM) women using Gated SPECT (GSPECT) and to study the impact of other. risk factors like hypertension (HTN), dyslipidemia, family history and menopause. This is a prospective cross-sectional study on a consecutive sample of 287 women referred to Nuclear Cardiology Department of Karachi Institute of Heart Diseases (KIHD) for GSPECT for evaluation of known or suspected CAD (from January 2009 till June 2009). Women with a history of DM diagnosed less than 5 years were excluded. Same day (reststress) GSPECT study was conducted and fixed or reversible perfusion defects were considered positive GSPECT for CAD. GSPECT was positive for CAD in 41/115 (36%, P 0.002) diabetic women and 37/172 (21 %, P 0.005) non-diabetic cohort. In diabetic cohort, GSPECT was positive in 5/9 (56%, P 0.013) women with diabetes only, 17/35 (48%, P 0.02) DM with HTN, 12/15 (80%, P value 0.02) DM with dyslipidemia and 11/43 (26%, P 0.001) DM with >2 risk factors. GSPECT was normal in all 3 diabetic women with positive family history for CAD. In nondiabetic cohort, GSPECT was positive in 9/32 (28%, P  More>>
Authors:
Maseeh-uz-Zaman,; Fatima, N; Samad, A; Rasheed, S Z; Ishaq, M; Rehman, K; Wali, A [1] 
  1. Karachi, Inst. of Heart Diseases, Karachi (Pakistan)
Publication Date:
Jul 15, 2009
Product Type:
Journal Article
Resource Relation:
Journal Name: Pakistan Journal of Cardiology; Journal Volume: 20; Journal Issue: 3-4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIES; CORONARIES; DIABASES; MYOCARDIAL INFARCTION; RISK ASSESSMENT; BASALT; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; IGNEOUS ROCKS; ORGANS; ROCKS; VOLCANIC ROCKS
OSTI ID:
21355920
Country of Origin:
Pakistan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1016-1244; TRN: PK1000485090206
Submitting Site:
INIS
Size:
page(s) 3-9
Announcement Date:
Nov 19, 2010

Journal Article:

Citation Formats

Maseeh-uz-Zaman,, Fatima, N, Samad, A, Rasheed, S Z, Ishaq, M, Rehman, K, and Wali, A. Prevalence of positive gated myocardial SPECT in diabetic and non-diabetic women and impact of other factors; KIHD perspective. Pakistan: N. p., 2009. Web.
Maseeh-uz-Zaman,, Fatima, N, Samad, A, Rasheed, S Z, Ishaq, M, Rehman, K, & Wali, A. Prevalence of positive gated myocardial SPECT in diabetic and non-diabetic women and impact of other factors; KIHD perspective. Pakistan.
Maseeh-uz-Zaman,, Fatima, N, Samad, A, Rasheed, S Z, Ishaq, M, Rehman, K, and Wali, A. 2009. "Prevalence of positive gated myocardial SPECT in diabetic and non-diabetic women and impact of other factors; KIHD perspective." Pakistan.
@misc{etde_21355920,
title = {Prevalence of positive gated myocardial SPECT in diabetic and non-diabetic women and impact of other factors; KIHD perspective}
author = {Maseeh-uz-Zaman,, Fatima, N, Samad, A, Rasheed, S Z, Ishaq, M, Rehman, K, and Wali, A}
abstractNote = {The objective of the present study was to assess the prevalence of coronary artery disease (CAD) among diabetic (DM) and nondiabetic (NDM) women using Gated SPECT (GSPECT) and to study the impact of other. risk factors like hypertension (HTN), dyslipidemia, family history and menopause. This is a prospective cross-sectional study on a consecutive sample of 287 women referred to Nuclear Cardiology Department of Karachi Institute of Heart Diseases (KIHD) for GSPECT for evaluation of known or suspected CAD (from January 2009 till June 2009). Women with a history of DM diagnosed less than 5 years were excluded. Same day (reststress) GSPECT study was conducted and fixed or reversible perfusion defects were considered positive GSPECT for CAD. GSPECT was positive for CAD in 41/115 (36%, P 0.002) diabetic women and 37/172 (21 %, P 0.005) non-diabetic cohort. In diabetic cohort, GSPECT was positive in 5/9 (56%, P 0.013) women with diabetes only, 17/35 (48%, P 0.02) DM with HTN, 12/15 (80%, P value 0.02) DM with dyslipidemia and 11/43 (26%, P 0.001) DM with >2 risk factors. GSPECT was normal in all 3 diabetic women with positive family history for CAD. In nondiabetic cohort, GSPECT was positive in 9/32 (28%, P value 0.739) women with no risk factor, 5/58 (26%, P 0.866) HTN only, 2/5 (40%, P value 0.655) only dyslipidemic women, 1/12. (8%, P 0.004) with family history only and 4/23 (17%, P value 0.166) non-diabetic with >2 risk factors. Interestingly, 35/93 post-menopausal diabetic (38%, p value 0.017) had positive GSPECT while 33/123 non-diabetic postmenopausal women (27%, p 0.03) had positive perfusion scans. GSPECT was positive in 6/26 (23%, P 0.006) and 4/49 (8%, P 0.05) in diabetic and non-diabetic pre-menopausal women. The prevalence of CAD in our diabetic women is as high as internationally reported and diabetes is a strong risk factor for CAD. Dyslipidemia with diabetes is a major contributor to CAD than HTN and F/H. Diabetes erases the protective effect of estrogen in premenopausal diabetic women. (author)}
journal = {Pakistan Journal of Cardiology}
issue = {3-4}
volume = {20}
place = {Pakistan}
year = {2009}
month = {Jul}
}