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The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels

Journal Article:

Abstract

This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 38 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R2 of 0.220.45, P<.005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
Authors:
Adams, J B; Mitchell, I J; [1]  Baral, M; Bradstreet, J; [2]  Geis, E; Ingram, J; Hensley, A; Zappia, I; Gehn, E; Mitchell, K; [3]  Newmark, S; [4]  Rubin, R A; [5]  Bradstreet, J; [6]  El-Dahrn, J M [7] 
  1. Division of Basic Medical Sciences, Southwest College of Naturopathic Medicine, Tempe, AZ 85282 (United States)
  2. Department of Pediatric Medicine, Southwest College of Naturopathic Medicine, Tempe, AZ 85282 (United States)
  3. Autism Research Institute, San Diego, CA 92116-2599 (United States)
  4. Center for Integrative Pediatric Medicine, Tucson, AZ 85711 (United States)
  5. Department of Mathematics, Whittier College, Whittier, CA 90601-4413 (United States)
  6. International Child Development Resource Center, Phoenix, AZ (United States)
  7. Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112 (United States)
Publication Date:
Jul 01, 2009
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of Toxicology (Print); Journal Volume: 2009; Journal Issue: 2009
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD CELLS; BODY BURDEN; CHILDREN; CORRELATIONS; EXCRETION; GLUTATHIONE; METALS; SYMPTOMS; TOXICITY; URINE; AGE GROUPS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY FLUIDS; CLEARANCE; DRUGS; ELEMENTS; MAMMALS; MAN; MATERIALS; ORGANIC COMPOUNDS; PEPTIDES; POLYPEPTIDES; PRIMATES; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; VERTEBRATES; WASTES
OSTI ID:
21352827
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1687-8191; TRN: EG1000625087073
Submitting Site:
INIS
Size:
page(s) 7
Announcement Date:
Nov 19, 2010

Journal Article:

Citation Formats

Adams, J B, Mitchell, I J, Baral, M, Bradstreet, J, Geis, E, Ingram, J, Hensley, A, Zappia, I, Gehn, E, Mitchell, K, Newmark, S, Rubin, R A, Bradstreet, J, and El-Dahrn, J M. The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels. Egypt: N. p., 2009. Web.
Adams, J B, Mitchell, I J, Baral, M, Bradstreet, J, Geis, E, Ingram, J, Hensley, A, Zappia, I, Gehn, E, Mitchell, K, Newmark, S, Rubin, R A, Bradstreet, J, & El-Dahrn, J M. The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels. Egypt.
Adams, J B, Mitchell, I J, Baral, M, Bradstreet, J, Geis, E, Ingram, J, Hensley, A, Zappia, I, Gehn, E, Mitchell, K, Newmark, S, Rubin, R A, Bradstreet, J, and El-Dahrn, J M. 2009. "The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels." Egypt.
@misc{etde_21352827,
title = {The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels}
author = {Adams, J B, Mitchell, I J, Baral, M, Bradstreet, J, Geis, E, Ingram, J, Hensley, A, Zappia, I, Gehn, E, Mitchell, K, Newmark, S, Rubin, R A, Bradstreet, J, and El-Dahrn, J M}
abstractNote = {This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 38 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R2 of 0.220.45, P<.005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.}
journal = {Journal of Toxicology (Print)}
issue = {2009}
volume = {2009}
place = {Egypt}
year = {2009}
month = {Jul}
}