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Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer

Abstract

Purpose: Aim of this study was to correlate dose to pharyngeal constrictors (PC) with subjective and observer-based assessments of swallowing in patients with head and neck cancer undergoing concomitant chemo-IMRT. Materials and methods: Dose-volume histograms (DVHs) for superior constrictor (SC), middle constrictor (MC) and inferior constrictor (IC) were generated for 37 patients. Mean doses to SC, MC and IC were correlated to objective dysphagia grade (1 year, RTOG scoring) and global, total physical (TP) and most relevant components of the physical section (P6, P8) of the MD Anderson dysphagia inventory (MDADI) which was evaluated post-treatment. Odds ratios of dysphagia (>grade 0), poor global (<3), TP (<32), P6 (<3) and P8 (<3) for patients with mean dose > 60 Gy to SC and IC were calculated. Results: There was no significant correlation between mean dose to PC and any of the analysed MDADI parameters and observer-assessed dysphagia grade. Odds ratio of dysphagia (>grade 0), poor global (<3), TP (<32), P6 (<3) and P8 (<3) for patients with mean dose > 60 Gy to IC and SC were not significantly higher than those for patients receiving <60 Gy. Conclusion: This study did not find a statistically significant correlation between radiation dose to  More>>
Publication Date:
Dec 15, 2009
Product Type:
Journal Article
Resource Relation:
Journal Name: Radiotherapy and Oncology; Journal Volume: 93; Journal Issue: 3; Other Information: DOI: 10.1016/j.radonc.2009.09.017; PII: S0167-8140(09)00565-9; Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEAD; NECK; NEOPLASMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; BODY; DISEASES; DOSES; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; THERAPY
OSTI ID:
21343469
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0167-8140; RAONDT; TRN: IE10R0066074347
Availability:
Available from http://dx.doi.org/10.1016/j.radonc.2009.09.017
Submitting Site:
INIS
Size:
page(s) 539-544
Announcement Date:
Oct 26, 2010

Citation Formats

Bhide, Shreerang A., E-mail: sabhide@yahoo.co [Institute of Cancer Research, London (United Kingdom), Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], Gulliford, Sarah, Kazi, Rehan, El-Hariry, Iman, Newbold, Kate, Harrington, Kevin J, Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], and Nutting, Christopher M. Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer. Ireland: N. p., 2009. Web. doi:10.1016/j.radonc.2009.09.017.
Bhide, Shreerang A., E-mail: sabhide@yahoo.co [Institute of Cancer Research, London (United Kingdom), Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], Gulliford, Sarah, Kazi, Rehan, El-Hariry, Iman, Newbold, Kate, Harrington, Kevin J, Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], & Nutting, Christopher M. Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer. Ireland. doi:10.1016/j.radonc.2009.09.017.
Bhide, Shreerang A., E-mail: sabhide@yahoo.co [Institute of Cancer Research, London (United Kingdom), Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], Gulliford, Sarah, Kazi, Rehan, El-Hariry, Iman, Newbold, Kate, Harrington, Kevin J, Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], and Nutting, Christopher M. 2009. "Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer." Ireland. doi:10.1016/j.radonc.2009.09.017. https://www.osti.gov/servlets/purl/10.1016/j.radonc.2009.09.017.
@misc{etde_21343469,
title = {Correlation between dose to the pharyngeal constrictors and patient quality of life and late dysphagia following chemo-IMRT for head and neck cancer}
author = {Bhide, Shreerang A., E-mail: sabhide@yahoo.co [Institute of Cancer Research, London (United Kingdom), Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], Gulliford, Sarah, Kazi, Rehan, El-Hariry, Iman, Newbold, Kate, Harrington, Kevin J, Royal Marsden NHS Foundation Trust Hospital, London (United Kingdom)], and Nutting, Christopher M}
abstractNote = {Purpose: Aim of this study was to correlate dose to pharyngeal constrictors (PC) with subjective and observer-based assessments of swallowing in patients with head and neck cancer undergoing concomitant chemo-IMRT. Materials and methods: Dose-volume histograms (DVHs) for superior constrictor (SC), middle constrictor (MC) and inferior constrictor (IC) were generated for 37 patients. Mean doses to SC, MC and IC were correlated to objective dysphagia grade (1 year, RTOG scoring) and global, total physical (TP) and most relevant components of the physical section (P6, P8) of the MD Anderson dysphagia inventory (MDADI) which was evaluated post-treatment. Odds ratios of dysphagia (>grade 0), poor global (<3), TP (<32), P6 (<3) and P8 (<3) for patients with mean dose > 60 Gy to SC and IC were calculated. Results: There was no significant correlation between mean dose to PC and any of the analysed MDADI parameters and observer-assessed dysphagia grade. Odds ratio of dysphagia (>grade 0), poor global (<3), TP (<32), P6 (<3) and P8 (<3) for patients with mean dose > 60 Gy to IC and SC were not significantly higher than those for patients receiving <60 Gy. Conclusion: This study did not find a statistically significant correlation between radiation dose to the PC and observer-assessed dysphagia grade or patient-reported MDADI questionnaire at 1 year.}
doi = {10.1016/j.radonc.2009.09.017}
journal = {Radiotherapy and Oncology}
issue = {3}
volume = {93}
place = {Ireland}
year = {2009}
month = {Dec}
}