Abstract
This prospective multicentre study assesses the usefulness of FDG PET/CT in characterizing and making the therapeutic decision concerning adrenal tumours that are suspicious or indeterminate in nature after conventional examinations (CE). Seventy-eight patients (37 men, 41 women, 81 adrenal lesions) underwent FDG PET/CT after CE including CT scan, biological tests and optionally {sup 131}I-metaiodobenzylguanidine (MIBG) and/or {sup 131}I-norcholesterol scans. FDG adrenal uptake exceeding that of the liver was considered positive. PET results were not decisive. Surgery was discussed when at least one of the following criteria was found during CE: size >3 cm, spontaneous attenuation value >10 HU, heterogeneous aspect, abnormal MIBG or norcholesterol scan or hormonal hypersecretion. Following the gold standard (histology analysis or {>=}9 months follow-up), 49 lesions potentially qualified for surgery (malignant = 27, benign secreting = 22) and 32 benign non-secreting lesions did not. PET was negative in 97% of non-surgical lesions and positive in 73% of potentially surgical ones which included all the malignant lesions, except 3 renal cell metastases, and 12 of 22 benign secreting lesions. The negative predictive value for malignancy was 93% (41/44) and positive predictive value for detecting surgical lesions was 97% (36/37). A high FDG uptake (maximum standardized uptake value
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Ansquer, Catherine;
[1]
INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France)];
Scigliano, Sonia;
[2]
Mirallie, Eric;
[3]
Taieb, David;
[4]
Brunaud, Laurent;
[5]
Sebag, Frederic;
[6]
Leux, Christophe;
[7]
Drui, Delphine;
[8]
Dupas, Benoit;
[9]
Renaudin, Karine;
[10]
Kraeber-Bodere, Francoise;
[1]
INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France);
Centre Rene Gauducheau, Service de Medecine Nucleaire, Saint Herblain Cedex (France)]
- CHU - Hotel Dieu, Service de Medecine Nucleaire, Nantes Cedex 1 (France)
- CHU Nancy-Brabois, Service de Medecine Nucleaire, Vandoeuvre les Nancy (France)
- CHU - Hotel Dieu, Service de Chirurgie Endocrinienne, Nantes Cedex 1 (France)
- CHU de la Timone, Service de Medecine Nucleaire, Marseille Cedex 5 (France)
- CHU Nancy-Brabois, Service de Chirurgie Endocrinienne, Vandoeuvre les Nancy (France)
- CHU de la Timone, Service de Chirurgie Endocrinienne, Marseille Cedex 5 (France)
- CHU - Hopital Saint Jacques, PIMESP, Nantes Cedex 1 (France)
- CHU - Hopital Nord Laennec, Service d'Endocrinologie, Nantes Cedex 1 (France)
- CHU - Hotel Dieu, Service de Radiologie, Nantes Cedex 1 (France)
- CHU - Hotel Dieu, Service d'Anatomo-pathologie, Nantes Cedex 1 (France)
Citation Formats
Ansquer, Catherine, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France)], Scigliano, Sonia, Mirallie, Eric, Taieb, David, Brunaud, Laurent, Sebag, Frederic, Leux, Christophe, Drui, Delphine, Dupas, Benoit, Renaudin, Karine, Kraeber-Bodere, Francoise, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France), and Centre Rene Gauducheau, Service de Medecine Nucleaire, Saint Herblain Cedex (France)].
{sup 18}F-FDG PET/CT in the characterization and surgical decision concerning adrenal masses: a prospective multicentre evaluation.
Germany: N. p.,
2010.
Web.
doi:10.1007/S00259-010-1471-8.
Ansquer, Catherine, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France)], Scigliano, Sonia, Mirallie, Eric, Taieb, David, Brunaud, Laurent, Sebag, Frederic, Leux, Christophe, Drui, Delphine, Dupas, Benoit, Renaudin, Karine, Kraeber-Bodere, Francoise, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France), & Centre Rene Gauducheau, Service de Medecine Nucleaire, Saint Herblain Cedex (France)].
{sup 18}F-FDG PET/CT in the characterization and surgical decision concerning adrenal masses: a prospective multicentre evaluation.
Germany.
https://doi.org/10.1007/S00259-010-1471-8
Ansquer, Catherine, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France)], Scigliano, Sonia, Mirallie, Eric, Taieb, David, Brunaud, Laurent, Sebag, Frederic, Leux, Christophe, Drui, Delphine, Dupas, Benoit, Renaudin, Karine, Kraeber-Bodere, Francoise, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France), and Centre Rene Gauducheau, Service de Medecine Nucleaire, Saint Herblain Cedex (France)].
2010.
"{sup 18}F-FDG PET/CT in the characterization and surgical decision concerning adrenal masses: a prospective multicentre evaluation."
Germany.
https://doi.org/10.1007/S00259-010-1471-8.
@misc{etde_21341989,
title = {{sup 18}F-FDG PET/CT in the characterization and surgical decision concerning adrenal masses: a prospective multicentre evaluation}
author = {Ansquer, Catherine, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France)], Scigliano, Sonia, Mirallie, Eric, Taieb, David, Brunaud, Laurent, Sebag, Frederic, Leux, Christophe, Drui, Delphine, Dupas, Benoit, Renaudin, Karine, Kraeber-Bodere, Francoise, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France), and Centre Rene Gauducheau, Service de Medecine Nucleaire, Saint Herblain Cedex (France)]}
abstractNote = {This prospective multicentre study assesses the usefulness of FDG PET/CT in characterizing and making the therapeutic decision concerning adrenal tumours that are suspicious or indeterminate in nature after conventional examinations (CE). Seventy-eight patients (37 men, 41 women, 81 adrenal lesions) underwent FDG PET/CT after CE including CT scan, biological tests and optionally {sup 131}I-metaiodobenzylguanidine (MIBG) and/or {sup 131}I-norcholesterol scans. FDG adrenal uptake exceeding that of the liver was considered positive. PET results were not decisive. Surgery was discussed when at least one of the following criteria was found during CE: size >3 cm, spontaneous attenuation value >10 HU, heterogeneous aspect, abnormal MIBG or norcholesterol scan or hormonal hypersecretion. Following the gold standard (histology analysis or {>=}9 months follow-up), 49 lesions potentially qualified for surgery (malignant = 27, benign secreting = 22) and 32 benign non-secreting lesions did not. PET was negative in 97% of non-surgical lesions and positive in 73% of potentially surgical ones which included all the malignant lesions, except 3 renal cell metastases, and 12 of 22 benign secreting lesions. The negative predictive value for malignancy was 93% (41/44) and positive predictive value for detecting surgical lesions was 97% (36/37). A high FDG uptake (maximum standardized uptake value {>=} 10) was highly predictive of malignancy. Adrenal FDG uptake is a good indicator of malignancy and/or of secreting lesions and should lead one to discuss surgery. If there is no prior history of poorly FDG-avid cancer, the absence of FDG uptake should avoid unnecessary removal of benign adrenal lesions. (orig.)}
doi = {10.1007/S00259-010-1471-8}
journal = []
issue = {9}
volume = {37}
place = {Germany}
year = {2010}
month = {Sep}
}
title = {{sup 18}F-FDG PET/CT in the characterization and surgical decision concerning adrenal masses: a prospective multicentre evaluation}
author = {Ansquer, Catherine, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France)], Scigliano, Sonia, Mirallie, Eric, Taieb, David, Brunaud, Laurent, Sebag, Frederic, Leux, Christophe, Drui, Delphine, Dupas, Benoit, Renaudin, Karine, Kraeber-Bodere, Francoise, INSERM UMR 892, CRCNA, Quai Moncousu, BP 70721, Nantes Cedex 1 (France), and Centre Rene Gauducheau, Service de Medecine Nucleaire, Saint Herblain Cedex (France)]}
abstractNote = {This prospective multicentre study assesses the usefulness of FDG PET/CT in characterizing and making the therapeutic decision concerning adrenal tumours that are suspicious or indeterminate in nature after conventional examinations (CE). Seventy-eight patients (37 men, 41 women, 81 adrenal lesions) underwent FDG PET/CT after CE including CT scan, biological tests and optionally {sup 131}I-metaiodobenzylguanidine (MIBG) and/or {sup 131}I-norcholesterol scans. FDG adrenal uptake exceeding that of the liver was considered positive. PET results were not decisive. Surgery was discussed when at least one of the following criteria was found during CE: size >3 cm, spontaneous attenuation value >10 HU, heterogeneous aspect, abnormal MIBG or norcholesterol scan or hormonal hypersecretion. Following the gold standard (histology analysis or {>=}9 months follow-up), 49 lesions potentially qualified for surgery (malignant = 27, benign secreting = 22) and 32 benign non-secreting lesions did not. PET was negative in 97% of non-surgical lesions and positive in 73% of potentially surgical ones which included all the malignant lesions, except 3 renal cell metastases, and 12 of 22 benign secreting lesions. The negative predictive value for malignancy was 93% (41/44) and positive predictive value for detecting surgical lesions was 97% (36/37). A high FDG uptake (maximum standardized uptake value {>=} 10) was highly predictive of malignancy. Adrenal FDG uptake is a good indicator of malignancy and/or of secreting lesions and should lead one to discuss surgery. If there is no prior history of poorly FDG-avid cancer, the absence of FDG uptake should avoid unnecessary removal of benign adrenal lesions. (orig.)}
doi = {10.1007/S00259-010-1471-8}
journal = []
issue = {9}
volume = {37}
place = {Germany}
year = {2010}
month = {Sep}
}