Abstract
This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB). Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions. By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951 {+-} 0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively. A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results. (orig.)
Yeh, Jun Jun;
[1]
Mei-Ho Institute of Technology, Pingtung (China);
China Medical University, Taichung (China)];
Chen, Solomon Chih-Cheng;
[1]
National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taipei (China)];
Teng, Wen-Bao;
Chou, Chun-Hsiung;
Hsieh, Shih-Peng;
Lee, Tsung-Lung;
[1]
Wu, Ming-Ting;
[2]
Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung (China)]
- Pingtung Christian Hospital, Pingtung (China)
- National Yang Ming University, Faculty of Medicine, School of Medicine, Taipei (China)
Citation Formats
Yeh, Jun Jun, Mei-Ho Institute of Technology, Pingtung (China), China Medical University, Taichung (China)], Chen, Solomon Chih-Cheng, National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taipei (China)], Teng, Wen-Bao, Chou, Chun-Hsiung, Hsieh, Shih-Peng, Lee, Tsung-Lung, Wu, Ming-Ting, and Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung (China)].
Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography.
Germany: N. p.,
2010.
Web.
doi:10.1007/S00330-010-1796-5.
Yeh, Jun Jun, Mei-Ho Institute of Technology, Pingtung (China), China Medical University, Taichung (China)], Chen, Solomon Chih-Cheng, National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taipei (China)], Teng, Wen-Bao, Chou, Chun-Hsiung, Hsieh, Shih-Peng, Lee, Tsung-Lung, Wu, Ming-Ting, & Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung (China)].
Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography.
Germany.
https://doi.org/10.1007/S00330-010-1796-5
Yeh, Jun Jun, Mei-Ho Institute of Technology, Pingtung (China), China Medical University, Taichung (China)], Chen, Solomon Chih-Cheng, National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taipei (China)], Teng, Wen-Bao, Chou, Chun-Hsiung, Hsieh, Shih-Peng, Lee, Tsung-Lung, Wu, Ming-Ting, and Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung (China)].
2010.
"Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography."
Germany.
https://doi.org/10.1007/S00330-010-1796-5.
@misc{etde_21339242,
title = {Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography}
author = {Yeh, Jun Jun, Mei-Ho Institute of Technology, Pingtung (China), China Medical University, Taichung (China)], Chen, Solomon Chih-Cheng, National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taipei (China)], Teng, Wen-Bao, Chou, Chun-Hsiung, Hsieh, Shih-Peng, Lee, Tsung-Lung, Wu, Ming-Ting, and Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung (China)]}
abstractNote = {This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB). Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions. By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951 {+-} 0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively. A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results. (orig.)}
doi = {10.1007/S00330-010-1796-5}
journal = []
issue = {9}
volume = {20}
place = {Germany}
year = {2010}
month = {Sep}
}
title = {Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography}
author = {Yeh, Jun Jun, Mei-Ho Institute of Technology, Pingtung (China), China Medical University, Taichung (China)], Chen, Solomon Chih-Cheng, National Taiwan University, Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taipei (China)], Teng, Wen-Bao, Chou, Chun-Hsiung, Hsieh, Shih-Peng, Lee, Tsung-Lung, Wu, Ming-Ting, and Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Department of Radiology, Kaohsiung (China)]}
abstractNote = {This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB). Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions. By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951 {+-} 0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively. A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results. (orig.)}
doi = {10.1007/S00330-010-1796-5}
journal = []
issue = {9}
volume = {20}
place = {Germany}
year = {2010}
month = {Sep}
}