Abstract
We studied the use of {sup 201}thallium SPECT and L-[1-{sup 11}C]-tyrosine PET in patients with a primary glioblastoma multiforme treated with {sup 192}Ir brachytherapy after surgery and external beam radiation therapy. We hypothesised that the patients most likely to benefit from further surgery after deterioration would be those with radiation necrosis and would be recognised by a negative emission tomography scan. Twenty-one patients underwent {sup 201}thallium SPECT performed before brachytherapy, and this was repeated in 19 patients when recurrence was suspected. Nine patients also underwent a PET scan at the same time. Nine patients underwent a second operation. SPECT and PET were highly concordant concerning the prediction of radionecrosis and/or tumor recurrence. Repeat surgery did not lead to a significant increase in survival. There was no significant association between the duration of survival and tumor-to-background ratio but the number studied was small. Both SPECT and PET showed highly active lesions, which were proved to be recurrent tumor by clinical and histological follow-up. Although PET and SPECT are both highly sensitive in detecting active tumor tissue, emission tomography was not clinically valuable in the investigation of patients with a primary glioblastoma treated with brachytherapy. (author)
Koot, R W;
Bosch, D A;
[1]
Habraken, J B.A.;
[2]
Academic Medical Center, Department of Radiology, University of Amsterdam, Amsterdam (Netherlands)];
Hulshof, M C.C.M.;
[3]
Paans, A M.J.;
Pruim, J. , e-mail: r.w.koot@lumc.nl
[4]
- Academic Medical Center, Department of Neurosurgery, University of Amsterdam, Amsterdam (Netherlands)
- Academic Medical Center, Department of Nuclear Medicine, University of Amsterdam, Amsterdam (Netherlands)
- Academic Medical Center, Department of Radiotherapy, University of Amsterdam, Amsterdam (Netherlands)
- Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, Groningen (Netherlands)
Citation Formats
Koot, R W, Bosch, D A, Habraken, J B.A., Academic Medical Center, Department of Radiology, University of Amsterdam, Amsterdam (Netherlands)], Hulshof, M C.C.M., Paans, A M.J., and Pruim, J. , e-mail: r.w.koot@lumc.nl.
What is the value of emission tomography studies in patients with a primary glioblastoma multiforme treated by {sup 192}Ir brachytherapy?.
Austria: N. p.,
2008.
Web.
doi:10.1007/S00701-007-1494-5.
Koot, R W, Bosch, D A, Habraken, J B.A., Academic Medical Center, Department of Radiology, University of Amsterdam, Amsterdam (Netherlands)], Hulshof, M C.C.M., Paans, A M.J., & Pruim, J. , e-mail: r.w.koot@lumc.nl.
What is the value of emission tomography studies in patients with a primary glioblastoma multiforme treated by {sup 192}Ir brachytherapy?.
Austria.
https://doi.org/10.1007/S00701-007-1494-5
Koot, R W, Bosch, D A, Habraken, J B.A., Academic Medical Center, Department of Radiology, University of Amsterdam, Amsterdam (Netherlands)], Hulshof, M C.C.M., Paans, A M.J., and Pruim, J. , e-mail: r.w.koot@lumc.nl.
2008.
"What is the value of emission tomography studies in patients with a primary glioblastoma multiforme treated by {sup 192}Ir brachytherapy?"
Austria.
https://doi.org/10.1007/S00701-007-1494-5.
@misc{etde_21314260,
title = {What is the value of emission tomography studies in patients with a primary glioblastoma multiforme treated by {sup 192}Ir brachytherapy?}
author = {Koot, R W, Bosch, D A, Habraken, J B.A., Academic Medical Center, Department of Radiology, University of Amsterdam, Amsterdam (Netherlands)], Hulshof, M C.C.M., Paans, A M.J., and Pruim, J. , e-mail: r.w.koot@lumc.nl}
abstractNote = {We studied the use of {sup 201}thallium SPECT and L-[1-{sup 11}C]-tyrosine PET in patients with a primary glioblastoma multiforme treated with {sup 192}Ir brachytherapy after surgery and external beam radiation therapy. We hypothesised that the patients most likely to benefit from further surgery after deterioration would be those with radiation necrosis and would be recognised by a negative emission tomography scan. Twenty-one patients underwent {sup 201}thallium SPECT performed before brachytherapy, and this was repeated in 19 patients when recurrence was suspected. Nine patients also underwent a PET scan at the same time. Nine patients underwent a second operation. SPECT and PET were highly concordant concerning the prediction of radionecrosis and/or tumor recurrence. Repeat surgery did not lead to a significant increase in survival. There was no significant association between the duration of survival and tumor-to-background ratio but the number studied was small. Both SPECT and PET showed highly active lesions, which were proved to be recurrent tumor by clinical and histological follow-up. Although PET and SPECT are both highly sensitive in detecting active tumor tissue, emission tomography was not clinically valuable in the investigation of patients with a primary glioblastoma treated with brachytherapy. (author)}
doi = {10.1007/S00701-007-1494-5}
journal = []
issue = {4}
volume = {150}
place = {Austria}
year = {2008}
month = {Jul}
}
title = {What is the value of emission tomography studies in patients with a primary glioblastoma multiforme treated by {sup 192}Ir brachytherapy?}
author = {Koot, R W, Bosch, D A, Habraken, J B.A., Academic Medical Center, Department of Radiology, University of Amsterdam, Amsterdam (Netherlands)], Hulshof, M C.C.M., Paans, A M.J., and Pruim, J. , e-mail: r.w.koot@lumc.nl}
abstractNote = {We studied the use of {sup 201}thallium SPECT and L-[1-{sup 11}C]-tyrosine PET in patients with a primary glioblastoma multiforme treated with {sup 192}Ir brachytherapy after surgery and external beam radiation therapy. We hypothesised that the patients most likely to benefit from further surgery after deterioration would be those with radiation necrosis and would be recognised by a negative emission tomography scan. Twenty-one patients underwent {sup 201}thallium SPECT performed before brachytherapy, and this was repeated in 19 patients when recurrence was suspected. Nine patients also underwent a PET scan at the same time. Nine patients underwent a second operation. SPECT and PET were highly concordant concerning the prediction of radionecrosis and/or tumor recurrence. Repeat surgery did not lead to a significant increase in survival. There was no significant association between the duration of survival and tumor-to-background ratio but the number studied was small. Both SPECT and PET showed highly active lesions, which were proved to be recurrent tumor by clinical and histological follow-up. Although PET and SPECT are both highly sensitive in detecting active tumor tissue, emission tomography was not clinically valuable in the investigation of patients with a primary glioblastoma treated with brachytherapy. (author)}
doi = {10.1007/S00701-007-1494-5}
journal = []
issue = {4}
volume = {150}
place = {Austria}
year = {2008}
month = {Jul}
}