You need JavaScript to view this

Tracheomegaly: a complication of fetal endoscopic tracheal occlusion in the treatment of congenital diaphragmatic hernia

Abstract

Fetal endoscopic tracheal occlusion (FETO) is a promising treatment for severe congenital diaphragmatic hernia, a condition that carries significant morbidity and mortality. It is hypothesised that balloon occlusion of the fetal trachea leads to an improvement in lung growth and development. The major documented complications of FETO to date are related to preterm delivery. To report a series of five infants who developed tracheomegaly following FETO. Review of all children referred with tracheomegaly to the paediatric intensive care and tracheal service at two referral centres. Five neonates presented with features of respiratory distress shortly after birth and were subsequently found to have marked tracheomegaly. Two neonates had tracheomalacia in addition. There are no previous reports in the literature describing tracheomalacia, or more specifically, tracheomegaly, as a consequence of FETO. We propose that the particularly compliant fetal airway is at risk of mechanical damage from in utero balloon occlusion. This observation of a new problem in this cohort suggests a thorough evaluation of the trachea should be performed in children who have had FETO in utero. It may be that balloon occlusion of the trachea earlier in utero (before 26 weeks' gestation) predisposes to this condition. (orig.)
Authors:
McHugh, Kieran; Afaq, Asim; Roebuck, Derek J; [1]  Broderick, Nigel; [2]  Gabra, Hany O; Elliott, Martin J [3] 
  1. Great Ormond Street Hospital for Children, Radiology Department, London (United Kingdom)
  2. Nottingham University Hospitals, Radiology Department, Nottingham (United Kingdom)
  3. Great Ormond Street Hospital for Children, Department of Cardiothoracic Surgery, London (United Kingdom)
Publication Date:
May 15, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Pediatric Radiology; Journal Volume: 40; Journal Issue: 5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPUTERIZED TOMOGRAPHY; CONGENITAL MALFORMATIONS; DIAPHRAGM; FETUSES; MALFORMATIONS; TRACHEA
OSTI ID:
21309574
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0301-0449; PDRYA5; TRN: DE10F6682
Availability:
Available from: http://dx.doi.org/10.1007/s00247-009-1437-9
Submitting Site:
DEN
Size:
page(s) 674-680
Announcement Date:
May 28, 2010

Citation Formats

McHugh, Kieran, Afaq, Asim, Roebuck, Derek J, Broderick, Nigel, Gabra, Hany O, and Elliott, Martin J. Tracheomegaly: a complication of fetal endoscopic tracheal occlusion in the treatment of congenital diaphragmatic hernia. Germany: N. p., 2010. Web. doi:10.1007/S00247-009-1437-9.
McHugh, Kieran, Afaq, Asim, Roebuck, Derek J, Broderick, Nigel, Gabra, Hany O, & Elliott, Martin J. Tracheomegaly: a complication of fetal endoscopic tracheal occlusion in the treatment of congenital diaphragmatic hernia. Germany. doi:10.1007/S00247-009-1437-9.
McHugh, Kieran, Afaq, Asim, Roebuck, Derek J, Broderick, Nigel, Gabra, Hany O, and Elliott, Martin J. 2010. "Tracheomegaly: a complication of fetal endoscopic tracheal occlusion in the treatment of congenital diaphragmatic hernia." Germany. doi:10.1007/S00247-009-1437-9. https://www.osti.gov/servlets/purl/10.1007/S00247-009-1437-9.
@misc{etde_21309574,
title = {Tracheomegaly: a complication of fetal endoscopic tracheal occlusion in the treatment of congenital diaphragmatic hernia}
author = {McHugh, Kieran, Afaq, Asim, Roebuck, Derek J, Broderick, Nigel, Gabra, Hany O, and Elliott, Martin J}
abstractNote = {Fetal endoscopic tracheal occlusion (FETO) is a promising treatment for severe congenital diaphragmatic hernia, a condition that carries significant morbidity and mortality. It is hypothesised that balloon occlusion of the fetal trachea leads to an improvement in lung growth and development. The major documented complications of FETO to date are related to preterm delivery. To report a series of five infants who developed tracheomegaly following FETO. Review of all children referred with tracheomegaly to the paediatric intensive care and tracheal service at two referral centres. Five neonates presented with features of respiratory distress shortly after birth and were subsequently found to have marked tracheomegaly. Two neonates had tracheomalacia in addition. There are no previous reports in the literature describing tracheomalacia, or more specifically, tracheomegaly, as a consequence of FETO. We propose that the particularly compliant fetal airway is at risk of mechanical damage from in utero balloon occlusion. This observation of a new problem in this cohort suggests a thorough evaluation of the trachea should be performed in children who have had FETO in utero. It may be that balloon occlusion of the trachea earlier in utero (before 26 weeks' gestation) predisposes to this condition. (orig.)}
doi = {10.1007/S00247-009-1437-9}
journal = {Pediatric Radiology}
issue = {5}
volume = {40}
place = {Germany}
year = {2010}
month = {May}
}