Abstract
Purpose: To determine whether childhood medulloblastoma and acute lymphoblastic leukemia (ALL) survivors have decreased white matter fractional anisotropy (WMFA) and whether WMFA is related to the speed of processing and motor speed. Methods and Materials: For this study, 17 patients (6 medulloblastoma, 5 ALL treated with high-dose methotrexate (MTX) (4 x 5 g/m{sup 2}) and 6 with low-dose MTX (3 x 2 g/m{sup 2})) and 17 age-matched controls participated. On a 3.0-T magnetic resonance imaging (MRI) scanner, diffusion tensor imaging (DTI) was performed, and WMFA values were calculated, including specific regions of interest (ROIs), and correlated with the speed of processing and motor speed. Results: Mean WMFA in the patient group, mean age 14 years (range 8.9 - 16.9), was decreased compared with the control group (p = 0.01), as well as WMFA in the right inferior fronto-occipital fasciliculus (IFO) (p = 0.03) and in the genu of the corpus callosum (gCC) (p = 0.01). Based on neurocognitive results, significant positive correlations were present between processing speed and WMFA in the splenium (sCC) (r = 0.53, p = 0.03) and the body of the corpus callosum (bCC) (r = 0.52, p = 0.03), whereas the right IFO WMFA was related
More>>
Aukema, Eline J. , E-mail: e.j.aukema@amc.uva.nl;
[1]
Caan, Matthan W.A.;
[2]
Delft University of Technology, Delft (Netherlands)];
Oudhuis, Nienke;
[1]
Majoie, Charles;
[2]
Vos, Frans M;
[2]
Delft University of Technology, Delft (Netherlands)];
Reneman, Liesbeth;
[2]
Last, Bob F;
[1]
Department of Developmental Psychology, Free University of Amsterdam, Amsterdam (Netherlands)];
Grootenhuis, Martha A;
[1]
Schouten-van Meeteren, Antoinette Y.N.
[3]
- Pediatric Psychosocial Department, Emma Children's Hospital/Academic Medical Center, Amsterdam (Netherlands)
- Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands)
- Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam (Netherlands)
Citation Formats
Aukema, Eline J. , E-mail: e.j.aukema@amc.uva.nl, Caan, Matthan W.A., Delft University of Technology, Delft (Netherlands)], Oudhuis, Nienke, Majoie, Charles, Vos, Frans M, Delft University of Technology, Delft (Netherlands)], Reneman, Liesbeth, Last, Bob F, Department of Developmental Psychology, Free University of Amsterdam, Amsterdam (Netherlands)], Grootenhuis, Martha A, and Schouten-van Meeteren, Antoinette Y.N.
White Matter Fractional Anisotropy Correlates With Speed of Processing and Motor Speed in Young Childhood Cancer Survivors.
United States: N. p.,
2009.
Web.
doi:10.1016/j.ijrobp.2008.08.060.
Aukema, Eline J. , E-mail: e.j.aukema@amc.uva.nl, Caan, Matthan W.A., Delft University of Technology, Delft (Netherlands)], Oudhuis, Nienke, Majoie, Charles, Vos, Frans M, Delft University of Technology, Delft (Netherlands)], Reneman, Liesbeth, Last, Bob F, Department of Developmental Psychology, Free University of Amsterdam, Amsterdam (Netherlands)], Grootenhuis, Martha A, & Schouten-van Meeteren, Antoinette Y.N.
White Matter Fractional Anisotropy Correlates With Speed of Processing and Motor Speed in Young Childhood Cancer Survivors.
United States.
https://doi.org/10.1016/j.ijrobp.2008.08.060
Aukema, Eline J. , E-mail: e.j.aukema@amc.uva.nl, Caan, Matthan W.A., Delft University of Technology, Delft (Netherlands)], Oudhuis, Nienke, Majoie, Charles, Vos, Frans M, Delft University of Technology, Delft (Netherlands)], Reneman, Liesbeth, Last, Bob F, Department of Developmental Psychology, Free University of Amsterdam, Amsterdam (Netherlands)], Grootenhuis, Martha A, and Schouten-van Meeteren, Antoinette Y.N.
2009.
"White Matter Fractional Anisotropy Correlates With Speed of Processing and Motor Speed in Young Childhood Cancer Survivors."
United States.
https://doi.org/10.1016/j.ijrobp.2008.08.060.
@misc{etde_21276872,
title = {White Matter Fractional Anisotropy Correlates With Speed of Processing and Motor Speed in Young Childhood Cancer Survivors}
author = {Aukema, Eline J. , E-mail: e.j.aukema@amc.uva.nl, Caan, Matthan W.A., Delft University of Technology, Delft (Netherlands)], Oudhuis, Nienke, Majoie, Charles, Vos, Frans M, Delft University of Technology, Delft (Netherlands)], Reneman, Liesbeth, Last, Bob F, Department of Developmental Psychology, Free University of Amsterdam, Amsterdam (Netherlands)], Grootenhuis, Martha A, and Schouten-van Meeteren, Antoinette Y.N.}
abstractNote = {Purpose: To determine whether childhood medulloblastoma and acute lymphoblastic leukemia (ALL) survivors have decreased white matter fractional anisotropy (WMFA) and whether WMFA is related to the speed of processing and motor speed. Methods and Materials: For this study, 17 patients (6 medulloblastoma, 5 ALL treated with high-dose methotrexate (MTX) (4 x 5 g/m{sup 2}) and 6 with low-dose MTX (3 x 2 g/m{sup 2})) and 17 age-matched controls participated. On a 3.0-T magnetic resonance imaging (MRI) scanner, diffusion tensor imaging (DTI) was performed, and WMFA values were calculated, including specific regions of interest (ROIs), and correlated with the speed of processing and motor speed. Results: Mean WMFA in the patient group, mean age 14 years (range 8.9 - 16.9), was decreased compared with the control group (p = 0.01), as well as WMFA in the right inferior fronto-occipital fasciliculus (IFO) (p = 0.03) and in the genu of the corpus callosum (gCC) (p = 0.01). Based on neurocognitive results, significant positive correlations were present between processing speed and WMFA in the splenium (sCC) (r = 0.53, p = 0.03) and the body of the corpus callosum (bCC) (r = 0.52, p = 0.03), whereas the right IFO WMFA was related to motor speed (r = 0.49, p < 0.05). Conclusions: White matter tracts, using a 3.0-T MRI scanner, show impairment in childhood cancer survivors, medulloblastoma survivors, and also those treated with high doses of MTX. In particular, white matter tracts in the sCC, bCC and right IFO are positively correlated with speed of processing and motor speed.}
doi = {10.1016/j.ijrobp.2008.08.060}
journal = []
issue = {3}
volume = {74}
place = {United States}
year = {2009}
month = {Jul}
}
title = {White Matter Fractional Anisotropy Correlates With Speed of Processing and Motor Speed in Young Childhood Cancer Survivors}
author = {Aukema, Eline J. , E-mail: e.j.aukema@amc.uva.nl, Caan, Matthan W.A., Delft University of Technology, Delft (Netherlands)], Oudhuis, Nienke, Majoie, Charles, Vos, Frans M, Delft University of Technology, Delft (Netherlands)], Reneman, Liesbeth, Last, Bob F, Department of Developmental Psychology, Free University of Amsterdam, Amsterdam (Netherlands)], Grootenhuis, Martha A, and Schouten-van Meeteren, Antoinette Y.N.}
abstractNote = {Purpose: To determine whether childhood medulloblastoma and acute lymphoblastic leukemia (ALL) survivors have decreased white matter fractional anisotropy (WMFA) and whether WMFA is related to the speed of processing and motor speed. Methods and Materials: For this study, 17 patients (6 medulloblastoma, 5 ALL treated with high-dose methotrexate (MTX) (4 x 5 g/m{sup 2}) and 6 with low-dose MTX (3 x 2 g/m{sup 2})) and 17 age-matched controls participated. On a 3.0-T magnetic resonance imaging (MRI) scanner, diffusion tensor imaging (DTI) was performed, and WMFA values were calculated, including specific regions of interest (ROIs), and correlated with the speed of processing and motor speed. Results: Mean WMFA in the patient group, mean age 14 years (range 8.9 - 16.9), was decreased compared with the control group (p = 0.01), as well as WMFA in the right inferior fronto-occipital fasciliculus (IFO) (p = 0.03) and in the genu of the corpus callosum (gCC) (p = 0.01). Based on neurocognitive results, significant positive correlations were present between processing speed and WMFA in the splenium (sCC) (r = 0.53, p = 0.03) and the body of the corpus callosum (bCC) (r = 0.52, p = 0.03), whereas the right IFO WMFA was related to motor speed (r = 0.49, p < 0.05). Conclusions: White matter tracts, using a 3.0-T MRI scanner, show impairment in childhood cancer survivors, medulloblastoma survivors, and also those treated with high doses of MTX. In particular, white matter tracts in the sCC, bCC and right IFO are positively correlated with speed of processing and motor speed.}
doi = {10.1016/j.ijrobp.2008.08.060}
journal = []
issue = {3}
volume = {74}
place = {United States}
year = {2009}
month = {Jul}
}