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Neuroimaging of autism

Abstract

Neuroimaging studies done by means of magnetic resonance imaging (MRI) have provided important insights into the neurobiological basis for autism. The aim of this article is to review the current state of knowledge regarding brain abnormalities in autism. Results of structural MRI studies dealing with total brain volume, the volume of the cerebellum, caudate nucleus, thalamus, amygdala and the area of the corpus callosum are summarised. In the past 5 years also new MRI applications as functional MRI and diffusion tensor imaging brought considerable new insights in the pathophysiological mechanisms of autism. Dysfunctional activation in key areas of verbal and non-verbal communication, social interaction, and executive functions are revised. Finally, we also discuss white matter alterations in important communication pathways in the brain of autistic patients. (orig.)
Authors:
Verhoeven, Judith S; Cock, Paul de; Lagae, Lieven; [1]  Sunaert, Stefan [2] 
  1. University Hospitals of the Catholic University of Leuven, Department of Pediatrics, Leuven (Belgium)
  2. University Hospitals of the Catholic University of Leuven, Department of Radiology, Leuven (Belgium)
Publication Date:
Jan 15, 2010
Product Type:
Journal Article
Resource Relation:
Journal Name: Neuroradiology; Journal Volume: 52; Journal Issue: 1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEHAVIOR; BRAIN; CONGENITAL MALFORMATIONS; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; NMR IMAGING
OSTI ID:
21275577
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0028-3940; NRDYAB; TRN: DE10F1720
Availability:
Available from: http://dx.doi.org/10.1007/s00234-009-0583-y
Submitting Site:
DEN
Size:
page(s) 3-14
Announcement Date:
Mar 09, 2010

Citation Formats

Verhoeven, Judith S, Cock, Paul de, Lagae, Lieven, and Sunaert, Stefan. Neuroimaging of autism. Germany: N. p., 2010. Web. doi:10.1007/S00234-009-0583-Y.
Verhoeven, Judith S, Cock, Paul de, Lagae, Lieven, & Sunaert, Stefan. Neuroimaging of autism. Germany. doi:10.1007/S00234-009-0583-Y.
Verhoeven, Judith S, Cock, Paul de, Lagae, Lieven, and Sunaert, Stefan. 2010. "Neuroimaging of autism." Germany. doi:10.1007/S00234-009-0583-Y. https://www.osti.gov/servlets/purl/10.1007/S00234-009-0583-Y.
@misc{etde_21275577,
title = {Neuroimaging of autism}
author = {Verhoeven, Judith S, Cock, Paul de, Lagae, Lieven, and Sunaert, Stefan}
abstractNote = {Neuroimaging studies done by means of magnetic resonance imaging (MRI) have provided important insights into the neurobiological basis for autism. The aim of this article is to review the current state of knowledge regarding brain abnormalities in autism. Results of structural MRI studies dealing with total brain volume, the volume of the cerebellum, caudate nucleus, thalamus, amygdala and the area of the corpus callosum are summarised. In the past 5 years also new MRI applications as functional MRI and diffusion tensor imaging brought considerable new insights in the pathophysiological mechanisms of autism. Dysfunctional activation in key areas of verbal and non-verbal communication, social interaction, and executive functions are revised. Finally, we also discuss white matter alterations in important communication pathways in the brain of autistic patients. (orig.)}
doi = {10.1007/S00234-009-0583-Y}
journal = {Neuroradiology}
issue = {1}
volume = {52}
place = {Germany}
year = {2010}
month = {Jan}
}