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Prospective Effects of Statin in Repression of Matrix Metalloproteinases Activities in Irradiated Rats

Journal Article:

Abstract

Several studies had been committed that HMG-CoA (3-Hydroxy-3 methylglutaryl coenzyme A) reductase inhibitors (statins) may exert a pleotropic effects attributed to mechanisms independent of their conventional hypolipidaemic effects. Meantime, inadequate studies have been sustained these independence mechanisms in regard to regulation and signal transduction of matrix metalloproteinases (MMPs). Sprague Dawley male albino rats were given by gavage atorvastatin; a synthetic form of statins, at a dose of I mg/kg body weight/day for 7 successive days before starting irradiation and 15 successive days during and along the exposure to {gamma}-radiation. Rats were exposed to fractionated whole body gamma radiation, delivered as 1 Gy every other day up to total dose of 8 Gy. Quantitative assay of gelatinolytic zymographic analysis of serum and hepatic tissues showed that exposure to {gamma} rays yields a marked significant increase in the activities of both pro-MMP-9 and active MMP-9 (92 and 86 kDa), as well as pro-MMP-2 and active MMP-2 (72 and 66 kDa), respectively. Administration of atorvastatin has significantly lowered the MMP-2 and MMP-9 enzymatic activity in y-irradiated rats, Conclusion: the present study demonstrated that irradiation of rats led to up regulation of enzymatic activities of MMP-2 and MMP-9 in their pro- and active forms.  More>>
Authors:
Zahran, A M; [1]  Sallam, M H [2] 
  1. Radiation Biology Department, National Centre/or Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo (Egypt)
  2. Health Radiation Research Department, Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo (Egypt)
Publication Date:
Jul 01, 2008
Product Type:
Journal Article
Resource Relation:
Journal Name: Journal of Radiation Research and Applied Sciences; Journal Volume: 2; Journal Issue: 2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BLOOD SERUM; COENZYMES; ENZYME ACTIVITY; GAMMA RADIATION; IRRADIATION; LIVER; MALES; OXIDATION; RADIATION DOSES; RADIOTHERAPY; RATS; REGULATIONS
OSTI ID:
21246672
Country of Origin:
Egypt
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1687-8507; TRN: EG09T0001107152
Submitting Site:
INIS
Size:
page(s) 213-233
Announcement Date:
Dec 23, 2009

Journal Article:

Citation Formats

Zahran, A M, and Sallam, M H. Prospective Effects of Statin in Repression of Matrix Metalloproteinases Activities in Irradiated Rats. Egypt: N. p., 2008. Web.
Zahran, A M, & Sallam, M H. Prospective Effects of Statin in Repression of Matrix Metalloproteinases Activities in Irradiated Rats. Egypt.
Zahran, A M, and Sallam, M H. 2008. "Prospective Effects of Statin in Repression of Matrix Metalloproteinases Activities in Irradiated Rats." Egypt.
@misc{etde_21246672,
title = {Prospective Effects of Statin in Repression of Matrix Metalloproteinases Activities in Irradiated Rats}
author = {Zahran, A M, and Sallam, M H}
abstractNote = {Several studies had been committed that HMG-CoA (3-Hydroxy-3 methylglutaryl coenzyme A) reductase inhibitors (statins) may exert a pleotropic effects attributed to mechanisms independent of their conventional hypolipidaemic effects. Meantime, inadequate studies have been sustained these independence mechanisms in regard to regulation and signal transduction of matrix metalloproteinases (MMPs). Sprague Dawley male albino rats were given by gavage atorvastatin; a synthetic form of statins, at a dose of I mg/kg body weight/day for 7 successive days before starting irradiation and 15 successive days during and along the exposure to {gamma}-radiation. Rats were exposed to fractionated whole body gamma radiation, delivered as 1 Gy every other day up to total dose of 8 Gy. Quantitative assay of gelatinolytic zymographic analysis of serum and hepatic tissues showed that exposure to {gamma} rays yields a marked significant increase in the activities of both pro-MMP-9 and active MMP-9 (92 and 86 kDa), as well as pro-MMP-2 and active MMP-2 (72 and 66 kDa), respectively. Administration of atorvastatin has significantly lowered the MMP-2 and MMP-9 enzymatic activity in y-irradiated rats, Conclusion: the present study demonstrated that irradiation of rats led to up regulation of enzymatic activities of MMP-2 and MMP-9 in their pro- and active forms. Administration of atorvastatin exerted defensive effects on {gamma} irradiated rats via down regulation of MMP-2 and MMP-9. Moreover, atorvastatin may be applied to minimize radiation-induced oxidative damage and attenuate the side effects of radiotherapy. However, these results observed in rats need to be confirmed in other experimental models.}
journal = {Journal of Radiation Research and Applied Sciences}
issue = {2}
volume = {2}
place = {Egypt}
year = {2008}
month = {Jul}
}